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Ubiquitination of NOTCH1 by ITCH in the absence of ligand
An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-1912386)
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Statements
instance of
biological process
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-1912386
part of
Activated NOTCH1 Transmits Signal to the Nucleus
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-1912386
found in taxon
Homo sapiens
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-1912386
exact match
https://identifiers.org/reactome:R-HSA-1912386
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-1912386
has part(s)
NOTCH1:NUMB:ITCH [plasma membrane]
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-1912386
Ub [cytosol]
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-1912386
Ub-NOTCH1:NUMB:ITCH [plasma membrane]
quantity
1
object has role
product
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-1912386
NOTCH1:NUMB:ITCH [plasma membrane]
quantity
1
object has role
modifier
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-1912386
cites work
Numb regulates post-endocytic trafficking and degradation of Notch1.
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-1912386
AIP4/Itch regulates Notch receptor degradation in the absence of ligand
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-1912386
Identifiers
Reactome ID
R-HSA-1912386
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-1912386
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