(Q21144278)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18628966%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

title

AIP4/Itch regulates Notch receptor degradation in the absence of ligand (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18628966%20AND%20SRC:MED&resulttype=core&format=json

Itchy E3 ubiquitin protein ligase

10 January 2020

main subject

1 reference

protein K29-linked ubiquitination

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

3

Christel Brou

Christel

Brou

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18628966%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Patricia Chastagner

1

Patricia

Chastagner

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18628966%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Alain Israël

series ordinal

2

author given names

Alain

author last names

Israël

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18628966%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

language of work or name

English

0 references

publication date

16 July 2008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18628966%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18628966%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

volume

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18628966%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

page(s)

e2735

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18628966%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18628966%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

10 January 2020

copyright license

start time

16 July 2008

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

The HECT ubiquitin ligase AIP4 regulates the cell surface expression of select TRP channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2444042

Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2444042

The ubiquitin-protein ligase Itch regulates p73 stability

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2444042

The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2444042

Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2444042

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2444042

Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2444042

The Notch1 receptor is cleaved constitutively by a furin-like convertase

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2444042

The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2444042

Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2444042

Specificity and Autoregulation of Notch Binding by Tandem WW Domains in Suppressor of Deltex

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2444042

Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2444042

The ubiquitin ligase itch is auto-ubiquitylated in vivo and in vitro but is protected from degradation by interacting with the deubiquitylating enzyme FAM/USP9X

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2444042

TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2444042

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2444042

Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2444042

Calcium depletion dissociates and activates heterodimeric notch receptors

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2444042

Notch signalling: a simple pathway becomes complex

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2444042

rab5 controls early endosome fusion in vitro

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2444042

Site-specific ubiquitination exposes a linear motif to promote interferon-alpha receptor endocytosis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2444042

EGF receptor ubiquitination is not necessary for its internalization

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2444042

The E3 ubiquitin ligase Itch controls the protein stability of p63

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2444042

Ubiquitin-mediated fluorescence complementation reveals that Jun ubiquitinated by Itch/AIP4 is localized to lysosomes.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2444042

The HECT domain ligase itch ubiquitinates endophilin and localizes to the trans-Golgi network and endosomal system

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2444042

Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2444042

Genetic characterization of the Drosophila melanogaster Suppressor of deltex gene: A regulator of notch signaling

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2444042

A member of the Notch group of interacting loci, deltex encodes a cytoplasmic basic protein

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2444042

Arrestin-2 interacts with the ubiquitin-protein isopeptide ligase atrophin-interacting protein 4 and mediates endosomal sorting of the chemokine receptor CXCR4.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2444042

Negative regulation of the E3 ubiquitin ligase itch via Fyn-mediated tyrosine phosphorylation.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2444042

AIP4 restricts transforming growth factor-beta signaling through a ubiquitination-independent mechanism

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2444042

Monoubiquitination and endocytosis direct gamma-secretase cleavage of activated Notch receptor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2444042

Hrs mediates downregulation of multiple signalling receptors in Drosophila

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2444042

c-Cbl binding and ubiquitin-dependent lysosomal degradation of membrane-associated Notch1.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2444042

The Drosophila melanogaster Suppressor of deltex gene, a regulator of the Notch receptor signaling pathway, is an E3 class ubiquitin ligase.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2444042

Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch

30 May 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002735

Drosophila Nedd4 regulates endocytosis of notch and suppresses its ligand-independent activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002735

Regulation of notch endosomal sorting and signaling by Drosophila Nedd4 family proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002735

Mutations in erupted, the Drosophila ortholog of mammalian tumor susceptibility gene 101, elicit non-cell-autonomous overgrowth

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002735

Tumor suppressor properties of the ESCRT-II complex component Vps25 in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002735

The Drosophila tumor suppressor vps25 prevents nonautonomous overproliferation by regulating notch trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002735

Regulation of Notch signalling by non-visual beta-arrestin

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002735

Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002735

Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002735

Itch genetically interacts with Notch1 in a mouse autoimmune disease model

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18628966

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0002735

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2391388

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18628966%20AND%20SRC:MED&resulttype=core&format=json

OpenCitations bibliographic resource ID

10 January 2020

ADS bibcode

2008PLoSO...3.2735C

0 references

2391388

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18628966%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

1 reference