(Q50298739)

English

PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-3601585)

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1 reference

8 July 2022

Disassembly of the destruction complex and recruitment of AXIN to the membrane

1 reference

8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-3601585

1 reference

8 July 2022

p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol]

quantity

1

object of statement has role

1 reference

8 July 2022

CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]

quantity

1

object of statement has role

1 reference

8 July 2022

p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol]

quantity

1

object of statement has role

1 reference

8 July 2022

Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex

1 reference

8 July 2022

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin

1 reference

8 July 2022

A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression

1 reference

8 July 2022

Wnt/beta-catenin signaling: components, mechanisms, and diseases

1 reference

8 July 2022

beta-catenin destruction complex: insights and questions from a structural perspective

1 reference

8 July 2022

Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex

1 reference

8 July 2022

APC is essential for targeting phosphorylated beta-catenin to the SCFbeta-TrCP ubiquitin ligase.

1 reference

8 July 2022

GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

(Q50298739)

PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex

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