(Q50335839)

5 March 2018

title

The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling. (English)

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5 March 2018

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5

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Andrew G Bowie

6

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author name string

Michael Carty

1

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5 March 2018

Rory Goodbody

2

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Martina Schröder

3

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Julianne Stack

4

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5 March 2018

language of work or name

English

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publication date

10 September 2006

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5 March 2018

number of pages

8

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based on heuristic

inferred from page(s)

published in

Nature Immunology

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5 March 2018

volume

7

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5 March 2018

issue

10

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page(s)

1074-1081

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Inferences, questions and possibilities in Toll-like receptor signalling

cites work

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TLR signalling and activation of IRFs: revisiting old friends from the NF-kappaB pathway

21 January 2018

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The Toll-IL-1 receptor adaptor family grows to five members.

21 January 2018

1 reference

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

21 January 2018

1 reference

The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction

21 January 2018

1 reference

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

21 January 2018

1 reference

TIRAP: an adapter molecule in the Toll signaling pathway

21 January 2018

1 reference

TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction

21 January 2018

1 reference

Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling

21 January 2018

1 reference

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

21 January 2018

1 reference

LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF

21 January 2018

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A novel human gene (SARM) at chromosome 17q11 encodes a protein with a SAM motif and structural similarity to Armadillo/beta-catenin that is conserved in mouse, Drosophila, and Caenorhabditis elegans.

21 January 2018

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TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM.

21 January 2018

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Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response

21 January 2018

1 reference

A Toll-interleukin 1 repeat protein at the synapse specifies asymmetric odorant receptor expression via ASK1 MAPKKK signaling.

21 January 2018

1 reference

Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif

21 January 2018

1 reference

SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling

21 January 2018

1 reference

ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance

21 January 2018

1 reference

Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

21 January 2018

1 reference

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

21 January 2018

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PKR--a protein kinase regulated by double-stranded RNA.

21 January 2018

1 reference

IRF-7 is the master regulator of type-I interferon-dependent immune responses

21 January 2018

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Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

21 January 2018

1 reference

Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling

21 January 2018

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RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation

21 January 2018

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IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway

21 January 2018

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Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence

21 January 2018

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Exogenous siRNA mediates sequence-independent gene suppression by signaling through toll-like receptor 3.

21 January 2018

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Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways.

21 January 2018

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Identification of a TLR4- and TRIF-dependent activation program of dendritic cells

21 January 2018

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Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF

21 January 2018

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Negative regulation of toll-like receptor-mediated immune responses

21 January 2018

1 reference

Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3...

21 January 2018

1 reference

SAM domains: uniform structure, diversity of function

21 January 2018

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IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1038/NI1382

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5 March 2018

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5 March 2018