(Q50433961)

13 March 2018

title

Can intratympanic dexamethasone protect against cisplatin ototoxicity in mice with age-related hearing loss? (English)

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13 March 2018

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Kourosh Parham

1

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13 March 2018

publication date

13 May 2011

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13 March 2018

Otolaryngology—Head and Neck Surgery

published in

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13 March 2018

volume

145

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13 March 2018

issue

4

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13 March 2018

page(s)

635-640

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13 March 2018

Cisplatin-induced ototoxicity: effect of intratympanic dexamethasone injections

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https://api.crossref.org/works/10.1177%2F0194599811409304

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Ototoxicity of cisplatin in gynaecological cancer patients.

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Mechanisms of cisplatin-induced ototoxicity and prevention

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Cisplatin cytotoxicity of auditory cells requires secretions of proinflammatory cytokines via activation of ERK and NF-kappaB.

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Dexamethasone treatment of naïve organ of Corti explants alters the expression pattern of apoptosis-related genes.

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Dexamethasone protects auditory hair cells against TNFalpha-initiated apoptosis via activation of PI3K/Akt and NFkappaB signaling.

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A corticosteroid-responsive transcription factor, promyelocytic leukemia zinc finger protein, mediates protection of the cochlea from acoustic trauma

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Ion homeostasis in the ear: mechanisms, maladies, and management

21 January 2018

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PTEN attenuates PIP3/Akt signaling in the cochlea of the aging CBA/J mouse

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21 January 2018

Identifiers

DOI

10.1177/0194599811409304

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13 March 2018

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13 March 2018