(Q5049051)

Death-like domain superfamily

1 reference

Caspase-2

1 reference

Peptidase C14, caspase non-catalytic subunit p10, protein family

1 reference

Peptidase family C14A, cysteine active site, protein family

1 reference

CARD domain, protein family

1 reference

Peptidase C14, p20 domain, protein family

1 reference

Peptidase C14A, caspase catalytic domain, protein family

1 reference

Peptidase family C14A, His active site, protein family

1 reference

protein domain specific binding

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

9 references

8 April 2019

RAIDD is a new 'death' adaptor molecule

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

8 April 2019

Characterization of a novel proapoptotic caspase-2- and caspase-9-binding protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

8 April 2019

ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

8 April 2019

Molecular cloning and characterization of DEFCAP-L and -S, two isoforms of a novel member of the mammalian Ced-4 family of apoptosis proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

8 April 2019

The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

8 April 2019

Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

8 April 2019

Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

8 April 2019

Pooled-matrix protein interaction screens using Barcode Fusion Genetics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

1 reference

8 April 2019

Molecular cloning and characterization of DEFCAP-L and -S, two isoforms of a novel member of the mammalian Ced-4 family of apoptosis proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

identical protein binding

3 references

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

8 April 2019

Caspase-2 is an initiator caspase responsible for pore-forming toxin-mediated apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

8 April 2019

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

cysteine-type endopeptidase activity involved in apoptotic process

IPI

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42575&geneProductId=UniProtKB:P42575

cysteine-type endopeptidase activity

5 references

8 April 2019

Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

8 April 2019

Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

8 April 2019

PAX2 suppresses apoptosis in renal collecting duct cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

8 April 2019

CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

cysteine-type endopeptidase activity involved in execution phase of apoptosis

IDA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

biological process

1 reference

8 April 2019

Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

execution phase of apoptosis

IMP

1 reference

8 April 2019

No death without life: vital functions of apoptotic effectors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

1 reference

8 April 2019

CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

positive regulation of apoptotic signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

cellular response to mechanical stimulus

1 reference

8 April 2019

Expression of the Bcl-2 protein BAD promotes prostate cancer growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

positive regulation of neuron apoptotic process

IEP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

intrinsic apoptotic signaling pathway in response to DNA damage

1 reference

8 April 2019

No death without life: vital functions of apoptotic effectors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

extrinsic apoptotic signaling pathway in absence of ligand

TAS

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42575&geneProductId=UniProtKB:P42575

positive regulation of apoptotic process

1 reference

8 April 2019

PAX2 suppresses apoptosis in renal collecting duct cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

ectopic germ cell programmed cell death

IDA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

neural retina development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

3 references

5 June 2018

Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42575&geneProductId=UniProtKB:P42575

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42575&geneProductId=UniProtKB:P42575

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42575&geneProductId=UniProtKB:P42575

2 references

negative regulation of apoptotic process

1 reference

8 April 2019

Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

4 references

8 April 2019

Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42575

physically interacts with

IBA

1 reference

Open Targets Platform

retrieved

14 August 2023

https://platform.opentargets.org/drug/CHEMBL197672

Gene Atlas image

PBB GE CASP2 34449 at fs.png
732 × 530; 11 KB

0 references

exact match

http://purl.uniprot.org/uniprot/P42575

1 reference

Peptidase family C14A, His active site

Identifiers.org

has part(s)

1 reference

Peptidase C14, p20 domain

1 reference

Peptidase C14A, caspase catalytic domain

1 reference

Peptidase C14, caspase non-catalytic subunit p10

1 reference

CARD domain

1 reference

Peptidase family C14A, cysteine active site

1 reference

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016