(Q50522405)

14 March 2018

title

An orally active chemokine receptor CCR2 antagonist prevents glomerulosclerosis and renal failure in type 2 diabetes. (English)

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14 March 2018

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10

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author name string

Sufyan G Sayyed

1

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14 March 2018

Mi Ryu

2

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14 March 2018

Onkar P Kulkarni

3

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14 March 2018

Holger Schmid

4

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14 March 2018

Julia Lichtnekert

5

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14 March 2018

Sabine Grüner

6

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14 March 2018

Luke Green

7

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14 March 2018

Patrizio Mattei

8

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14 March 2018

Guido Hartmann

9

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14 March 2018

language of work or name

English

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publication date

20 April 2011

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14 March 2018

published in

Kidney International

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14 March 2018

volume

80

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14 March 2018

issue

1

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14 March 2018

page(s)

68-78

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https://scigraph.springernature.com/pub.10.1038/ki.2011.102

exact match

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cites work

Signs of nephropathy may occur early in young adults with diabetes despite modern diabetes management: results from the nationwide population-based Diabetes Incidence Study in Sweden (DISS).

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

New insights into structural patterns encountered in glomerulosclerosis

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https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

The pathogenesis of diabetic nephropathy

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https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

From fibrosis to sclerosis: mechanisms of glomerulosclerosis in diabetic nephropathy

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https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

Linking metabolism and immunology: diabetic nephropathy is an inflammatory disease

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https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

The role of inflammation as a pathogenic factor in the development of renal disease in diabetes

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https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

Methotrexate prevents renal injury in experimental diabetic rats via anti-inflammatory actions

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https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

Mycophenolate mofetil prevents the development of glomerular injury in experimental diabetes

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https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

The pathogenesis of chronic renal failure in diabetic nephropathy. Investigation of 488 cases of diabetic glomerulosclerosis

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https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

The role of macrophages in diabetic glomerulosclerosis

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https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

Macrophages in mouse type 2 diabetic nephropathy: correlation with diabetic state and progressive renal injury

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https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

Macrophage diversity in renal injury and repair.

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https://api.crossref.org/works/10.1038%2FKI.2011.102

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CC chemokine ligand 5/RANTES chemokine antagonists aggravate glomerulonephritis despite reduction of glomerular leukocyte infiltration

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https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

Ex vivo programmed macrophages ameliorate experimental chronic inflammatory renal disease

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https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

The chemokine system in diverse forms of macrophage activation and polarization

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https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

Mediators of diabetic renal disease: the case for tgf-Beta as the major mediator

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https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

MCP-1/CCL2: a new diagnostic marker and therapeutic target for progressive renal injury in diabetic nephropathy

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https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

Association of monocyte chemoattractant protein-1 with renal tubular damage in diabetic nephropathy

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https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

Urinary levels of monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8), and renal injuries in patients with type 2 diabetic nephropathy.

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https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

Association between circulating monocyte chemoattractant protein-1 and urinary albumin excretion in nonobese Type 2 diabetic patients

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https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

A high glucose concentration stimulates the expression of monocyte chemotactic peptide 1 in human mesangial cells

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https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

Advanced glycation end product-induced apoptosis and overexpression of vascular endothelial growth factor and monocyte chemoattractant protein-1 in human-cultured mesangial cells

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https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

Chemokines and leukocyte traffic

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https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

Monocyte chemoattractant protein-1 promotes the development of diabetic renal injury in streptozotocin-treated mice

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https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

Monocyte chemoattractant protein-1-induced tissue inflammation is critical for the development of renal injury but not type 2 diabetes in obese db/db mice.

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https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

Late onset of Ccl2 blockade with the Spiegelmer mNOX-E36-3'PEG prevents glomerulosclerosis and improves glomerular filtration rate in db/db mice.

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https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

Progressive glomerulosclerosis in type 2 diabetes is associated with renal histone H3K9 and H3K23 acetylation, H3K4 dimethylation and phosphorylation at serine 10.

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https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

Recent developments in CCR2 antagonists

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https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

Podocyte loss and progressive glomerular injury in type II diabetes

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https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

Podocyte number in normotensive type 1 diabetic patients with albuminuria

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https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

CCR2: from cloning to the creation of knockout mice

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https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

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https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

Role of CC chemokine receptor 2 in bone marrow cells in the recruitment of macrophages into obese adipose tissue.

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https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice.

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https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

Macrophages, inflammation, and insulin resistance

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https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

Inhibition of CCR2 ameliorates insulin resistance and hepatic steatosis in db/db mice.

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https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

Regulation of the migration and survival of monocyte subsets by chemokine receptors and its relevance to atherosclerosis

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https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

The role of interstitial macrophages in nephropathy of type 2 diabetic db/db mice.

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https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

Podocytes produce homeostatic chemokine stromal cell-derived factor-1/CXCL12, which contributes to glomerulosclerosis, podocyte loss and albuminuria in a mouse model of type 2 diabetes.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

Renal failure increases cardiac histone h3 acetylation, dimethylation, and phosphorylation and the induction of cardiomyopathy-related genes in type 2 diabetes.

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https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

Anti-Ccl2 Spiegelmer permits 75% dose reduction of cyclophosphamide to control diffuse proliferative lupus nephritis and pneumonitis in MRL-Fas(lpr) mice

1 reference

https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

Trif is not required for immune complex glomerulonephritis: dying cells activate mesangial cells via Tlr2/Myd88 rather than Tlr3/Trif

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https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

Viral RNA and DNA trigger common antiviral responses in mesangial cells.

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https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

Bacterial lipopeptide triggers massive albuminuria in murine lupus nephritis by activating Toll-like receptor 2 at the glomerular filtration barrier

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https://api.crossref.org/works/10.1038%2FKI.2011.102

7 January 2021

Identifiers

DOI

10.1038/KI.2011.102

1 reference

14 March 2018

1 reference

14 March 2018