(Q50684056)

17 March 2018

title

Sensitivity Analysis of a Pharmacokinetic Model of Vaginal Anti-HIV Microbicide Drug Delivery. (English)

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17 March 2018

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Angela M Jarrett

1

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17 March 2018

Yajing Gao

2

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17 March 2018

M Yousuff Hussaini

3

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17 March 2018

Nicholas G Cogan

4

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17 March 2018

David F Katz

5

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17 March 2018

language of work or name

English

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publication date

22 March 2016

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17 March 2018

Journal of Pharmaceutical Sciences

published in

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17 March 2018

volume

105

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17 March 2018

issue

5

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17 March 2018

page(s)

1772-1778

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17 March 2018

Microbicide drug candidates to prevent HIV infection

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Microbicides: a new approach to preventing HIV and other sexually transmitted infections

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Intravaginal gels as drug delivery systems

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Topical microbicides to prevent HIV: clinical drug development challenges

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Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women

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HIV prevention in women: next steps

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Use of Pharmacokinetic Data in Novel Analyses to Determine the Effect of Topical Microbicides as Preexposure Prophylaxis Against HIV Infection

7 January 2021

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In vitro and ex vivo testing of tenofovir shows it is effective as an HIV-1 microbicide

7 January 2021

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Pharmacokinetic modelling of efavirenz, atazanavir, lamivudine and tenofovir in the female genital tract of HIV-infected pre-menopausal women

7 January 2021

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A multi-compartment, single and multiple dose pharmacokinetic study of the vaginal candidate microbicide 1% tenofovir gel

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Phase i/ii trial of the pharmacokinetics, safety, and antiretroviral activity of tenofovir disoproxil fumarate in human immunodeficiency virus-infected adults

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Squeezing flows of vaginal gel formulations relevant to microbicide drug delivery.

7 January 2021

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Interpreting properties of microbicide drug delivery gels: analyzing deployment kinetics due to squeezing

7 January 2021

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Dilution of microbicide gels with vaginal fluid and semen simulants: effect on rheological properties and coating flow.

7 January 2021

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Dynamics of HIV neutralization by a microbicide formulation layer: biophysical fundamentals and transport theory

7 January 2021

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Compartmental transport model of microbicide delivery by an intravaginal ring

7 January 2021

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Multicompartmental pharmacokinetic model of tenofovir delivery by a vaginal gel

7 January 2021

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Vaginal drug distribution modeling

7 January 2021

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Global sensitivity analysis used to interpret biological experimental results

7 January 2021

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A review of techniques for parameter sensitivity analysis of environmental models

7 January 2021

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A methodology for performing global uncertainty and sensitivity analysis in systems biology.

7 January 2021

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Intracellular pharmacokinetics of tenofovir diphosphate, carbovir triphosphate, and lamivudine triphosphate in patients receiving triple-nucleoside regimens

7 January 2021

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Single dose pharmacokinetics of oral tenofovir in plasma, peripheral blood mononuclear cells, colonic tissue, and vaginal tissue

7 January 2021

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10.1016/J.XPHS.2016.02.015

7 January 2021

Identifiers

DOI

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17 March 2018

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17 March 2018