(Q50721381)

18 March 2018

title

Quaternary ammonium block of mutant Na+ channels lacking inactivation: features of a transition-intermediate mechanism. (English)

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18 March 2018

author name string

J T Kimbrough

series ordinal

1

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18 March 2018

K J Gingrich

series ordinal

2

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18 March 2018

language of work or name

English

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publication date

1 November 2000

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18 March 2018

published in

Journal of Physiology

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18 March 2018

volume

529 Pt 1

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18 March 2018

page(s)

93-106

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18 March 2018

Meperidine and lidocaine block of recombinant voltage-dependent Na+ channels: evidence that meperidine is a local anesthetic

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1 reference

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A molecular basis for the different local anesthetic affinities of resting versus open and inactivated states of the sodium channel.

29 September 2018

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Interaction of batrachotoxin with the local anesthetic receptor site in transmembrane segment IVS6 of the voltage-gated sodium channel

29 September 2018

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Mechanistic link between lidocaine block and inactivation probed by outer pore mutations in the rat micro1 skeletal muscle sodium channel.

29 September 2018

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Local anesthetic block of batrachotoxin-resistant muscle Na+ channels

29 September 2018

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Sodium channel selectivity filter regulates antiarrhythmic drug binding

29 September 2018

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A common local anesthetic receptor for benzocaine and etidocaine in voltage-gated mu1 Na+ channels

29 September 2018

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Local anesthetics as effectors of allosteric gating. Lidocaine effects on inactivation-deficient rat skeletal muscle Na channels

29 September 2018

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Transfer of twelve charges is needed to open skeletal muscle Na+ channels

29 September 2018

1 reference

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Structure and function of voltage-dependent sodium channels: comparison of brain II and cardiac isoforms

29 September 2018

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The internal quaternary ammonium receptor site of Shaker potassium channels

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270171

Fast lidocaine block of cardiac and skeletal muscle sodium channels: one site with two routes of access.

29 September 2018

1 reference

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Functional expression of sodium channel mutations identified in families with periodic paralysis

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270171

Ultra-deep blockade of Na+ channels by a quaternary ammonium ion: catalysis by a transition-intermediate state?

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270171

Molecular determinants of state-dependent block of Na+ channels by local anesthetics

29 September 2018

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Effects of III-IV linker mutations on human heart Na+ channel inactivation gating

29 September 2018

1 reference

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Evidence for a direct interaction between internal tetra-alkylammonium cations and the inactivation gate of cardiac sodium channels

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270171

Internal block of human heart sodium channels by symmetrical tetra-alkylammoniums

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270171

Irreversible inhibition of sodium current and batrachotoxin binding by a photoaffinity-derivatized local anesthetic

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270171

On the molecular nature of the lidocaine receptor of cardiac Na+ channels. Modification of block by alterations in the alpha-subunit III-IV interdomain

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270171

Structure and function of voltage-gated ion channels

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270171

Inhibition of binding of [3H]batrachotoxinin A 20-alpha-benzoate to sodium channels by local anesthetics

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270171

Bis-quaternary ammonium blockers as structural probes of the sarcoplasmic reticulum K+ channel

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270171

Relief of Na+ block of Ca2+-activated K+ channels by external cations

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270171

Ionic permeation and blockade in Ca2+-activated K+ channels of bovine chromaffin cells

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270171

The site of action and active form of local anesthetics. II. Experiments with quaternary compounds

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270171

Interaction of Tetraethylammonium Ion Derivatives with the Potassium Channels of Giant Axons

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270171

The Inhibition of Sodium Currents in Myelinated Nerve by Quaternary Derivatives of Lidocaine

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270171

Why do some drugs preferentially block open sodium channels?

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270171

Data transformations for improved display and fitting of single-channel dwell time histograms

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270171

Inhibition of sodium currents by local anesthetics in chloramine-T-treated squid axons. The role of channel activation

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270171

Molecular and structural basis of resting and use-dependent block of sodium current defined using disopyramide analogues

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270171

Correcting single channel data for missed events

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270171

Internal and external TEA block in single cloned K+ channels

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270171

The aromatic binding site for tetraethylammonium ion on potassium channels

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270171

A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270171

Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270171

Sodium inactivation mechanism modulates QX-314 block of sodium channels in squid axons

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270171

Local anesthetic block of sodium channels in normal and pronase-treated squid giant axons

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270171

Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270171

Interactions between quaternary lidocaine, the sodium channel gates, and tetrodotoxin

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270171

10.1111/J.1469-7793.2000.00093.X

29 September 2018

Identifiers

DOI

1 reference

18 March 2018

PMC publication ID

2270171

0 references

1 reference

18 March 2018