(Q50726063)

18 March 2018

title

Nrf2 possesses a redox-sensitive nuclear exporting signal in the Neh5 transactivation domain. (English)

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18 March 2018

author name string

Wenge Li

series ordinal

1

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18 March 2018

Si-Wang Yu

series ordinal

2

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18 March 2018

A-N Tony Kong

series ordinal

3

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18 March 2018

language of work or name

English

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publication date

21 June 2006

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18 March 2018

Journal of Biological Chemistry

number of pages

13

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based on heuristic

inferred from page(s)

published in

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18 March 2018

volume

281

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18 March 2018

issue

37

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18 March 2018

page(s)

27251-27263

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18 March 2018

Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene

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Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region

21 January 2018

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Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.

21 January 2018

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Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

21 January 2018

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Comparison of (-)-epigallocatechin-3-gallate elicited liver and small intestine gene expression profiles between C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice.

21 January 2018

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Modulation of nuclear factor E2-related factor 2-mediated gene expression in mice liver and small intestine by cancer chemopreventive agent curcumin

21 January 2018

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Nrf2 is essential for protection against acute pulmonary injury in mice

21 January 2018

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High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes

21 January 2018

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Regulation of nuclear localization: a key to a door

21 January 2018

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Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins

21 January 2018

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Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors

21 January 2018

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Genetic evidence that small maf proteins are essential for the activation of antioxidant response element-dependent genes

21 January 2018

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The heme-responsive element of the mouse heme oxygenase-1 gene is an extended AP-1 binding site that resembles the recognition sequences for MAF and NF-E2 transcription factors

21 January 2018

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Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system.

21 January 2018

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An electrophile responsive element (EpRE) regulates beta-naphthoflavone induction of the human gamma-glutamylcysteine synthetase regulatory subunit gene. Constitutive expression is mediated by an adjacent AP-1 site

21 January 2018

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Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

21 January 2018

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Nrf2-Keap1 defines a physiologically important stress response mechanism

21 January 2018

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Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene

21 January 2018

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Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

21 January 2018

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Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome

21 January 2018

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Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

21 January 2018

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Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes

21 January 2018

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The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase

21 January 2018

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BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase

21 January 2018

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Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex

21 January 2018

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Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers

21 January 2018

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Keap1 regulates the oxidation-sensitive shuttling of Nrf2 into and out of the nucleus via a Crm1-dependent nuclear export mechanism

21 January 2018

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Nuclear oncoprotein prothymosin alpha is a partner of Keap1: implications for expression of oxidative stress-protecting genes.

21 January 2018

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Nrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1

21 January 2018

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Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity.

21 January 2018

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Site-directed mutagenesis of cysteine to serine in the DNA binding region of Nrf2 decreases its capacity to upregulate antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene

21 January 2018

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Nrf2 Possesses a redox-insensitive nuclear export signal overlapping with the leucine zipper motif.

21 January 2018

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Nuclear import and export signals in control of Nrf2.

21 January 2018

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Regulation of Nrf2 transactivation domain activity. The differential effects of mitogen-activated protein kinase cascades and synergistic stimulatory effect of Raf and CREB-binding protein

21 January 2018

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Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

21 January 2018

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Reliable and global measurement of fluorescence resonance energy transfer using fluorescence microscopes

21 January 2018

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21 January 2018

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Protein sequence requirements for function of the human T-cell leukemia virus type 1 Rex nuclear export signal delineated by a novel in vivo randomization-selection assay

21 January 2018

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CRM1 is an export receptor for leucine-rich nuclear export signals

21 January 2018

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Mutual exclusivity of DNA binding and nuclear localization signal recognition by the yeast transcription factor GAL4: implications for nonviral DNA delivery

21 January 2018

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Chemical and molecular regulation of enzymes that detoxify carcinogens

21 January 2018

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Oxidative stress abolishes leptomycin B-sensitive nuclear export of transcription repressor Bach2 that counteracts activation of Maf recognition element

21 January 2018

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Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription

21 January 2018

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In vivo pharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat.

21 January 2018

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Utility of siRNA against Keap1 as a strategy to stimulate a cancer chemopreventive phenotype

21 January 2018

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Crm1p mediates regulated nuclear export of a yeast AP-1-like transcription factor

21 January 2018

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Regulation of the yeast Yap1p nuclear export signal is mediated by redox signal-induced reversible disulfide bond formation

21 January 2018

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Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis

21 January 2018

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Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602746200

Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602746200

Cloning and characterization of the human glutathione synthetase 5'-flanking region

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M602746200

21 January 2018

Glutathione transferases

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https://api.crossref.org/works/10.1074%2FJBC.M602746200

A keaper and a striker maintain epidermal homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602746200

Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602746200

Retinoid X receptor regulates Nur77/TR3-dependent apoptosis [corrected] by modulating its nuclear export and mitochondrial targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602746200

Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602746200

Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602746200

21 January 2018

Identifiers

DOI

10.1074/JBC.M602746200

1 reference

18 March 2018

1 reference

18 March 2018