(Q50737128)

18 March 2018

title

Mathematical models of morphogen gradients and their effects on gene expression. (English)

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18 March 2018

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Stanislav Y Shvartsman

series ordinal

1

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18 March 2018

Ruth E Baker

series ordinal

2

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publication date

12 April 2012

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Wiley interdisciplinary reviews. Developmental biology

published in

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volume

1

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issue

5

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page(s)

715-730

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18 March 2018

Positional information and the spatial pattern of cellular differentiation

cites work

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One hundred years of positional information

21 January 2018

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The interpretation of morphogen gradients

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Morphogen gradient formation

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The chemical basis of morphogenesis

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The gradient morphogen bicoid is a concentration-dependent transcriptional activator.

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A gradient of bicoid protein in Drosophila embryos

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The bicoid protein determines position in the Drosophila embryo in a concentration-dependent manner

21 January 2018

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Relocalization of the dorsal protein from the cytoplasm to the nucleus correlates with its function.

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A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo.

21 January 2018

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The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila.

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The bicoid morphogen system

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How the Dorsal gradient works: insights from postgenome technologies

21 January 2018

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In and out of Torso RTK signalling.

21 January 2018

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Making a grade: Sonic Hedgehog signalling and the control of neural cell fate

21 January 2018

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Vnd/nkx, ind/gsh, and msh/msx: conserved regulators of dorsoventral neural patterning?

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Stability and nuclear dynamics of the bicoid morphogen gradient

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High mobility of bicoid captured by fluorescence correlation spectroscopy: implication for the rapid establishment of its gradient

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Dynamics of the Dorsal morphogen gradient

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Dynamical analysis of regulatory interactions in the gap gene system of Drosophila melanogaster

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Dynamic control of positional information in the early Drosophila embryo.

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Bicoid cooperative DNA binding is critical for embryonic patterning in Drosophila

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Canalization of gene expression in the Drosophila blastoderm by gap gene cross regulation

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Organism-scale modeling of early Drosophila patterning via bone morphogenetic proteins

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Precision of the Dpp gradient.

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Kinetics of morphogen gradient formation.

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The cis-regulatory logic of Hedgehog gradient responses: key roles for gli binding affinity, competition, and cooperativity

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Shadow enhancers foster robustness of Drosophila gastrulation

21 January 2018

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Quantitative and predictive model of transcriptional control of the Drosophila melanogaster even skipped gene.

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Reverse engineering the gap gene network of Drosophila melanogaster

21 January 2018

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Size regulation in the segmentation of Drosophila: interacting interfaces between localized domains of gene expression ensure robust spatial patterning.

21 January 2018

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Stripe formation in the early fly embryo: principles, models, and networks

21 January 2018

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Computational models for neurogenic gene expression in the Drosophila embryo.

21 January 2018

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Gene circuit analysis of the terminal gap gene huckebein

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Robust, bistable patterning of the dorsal surface of the Drosophila embryo

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Robustness of the BMP morphogen gradient in Drosophila embryonic patterning.

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Formation of the BMP activity gradient in the Drosophila embryo

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Elucidating mechanisms underlying robustness of morphogen gradients

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Diffusion in embryogenesis

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Do morphogen gradients arise by diffusion?

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How long does it take to establish a morphogen gradient?

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Local kinetics of morphogen gradients

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Formation of morphogen gradients: local accumulation time

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The formation of the Bicoid morphogen gradient requires protein movement from anteriorly localized mRNA

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Modelling the Bicoid gradient

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Measurement and perturbation of morphogen lifetime: effects on gradient shape

21 January 2018

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Functions and mechanisms of receptor tyrosine kinase Torso signaling: lessons from Drosophila embryonic terminal development

21 January 2018

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Hrs regulates endosome membrane invagination and tyrosine kinase receptor signaling in Drosophila

21 January 2018

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Torso receptor activity is regulated by a diffusible ligand produced at the extracellular terminal regions of the Drosophila egg

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The torso receptor localizes as well as transduces the spatial signal specifying terminal body pattern in Drosophila.

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Dual roles for patched in sequestering and transducing Hedgehog

21 January 2018

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Signaling gradients in cascades of two-state reaction-diffusion systems.

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Nuclear trapping shapes the terminal gradient in the Drosophila embryo.

21 January 2018

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MAPK substrate competition integrates patterning signals in the Drosophila embryo

21 January 2018

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The zinc-finger protein Zelda is a key activator of the early zygotic genome in Drosophila

21 January 2018

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Design flexibility in cis-regulatory control of gene expression: synthetic and comparative evidence

21 January 2018

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Transcriptional regulation by the numbers: applications

21 January 2018

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Thermodynamic modeling of transcription: sensitivity analysis differentiates biological mechanism from mathematical model-induced effects

21 January 2018

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Anterior-posterior positional information in the absence of a strong Bicoid gradient

21 January 2018

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Antagonistic action of Bicoid and the repressor Capicua determines the spatial limits of Drosophila head gene expression domains

21 January 2018

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Network motifs: theory and experimental approaches

21 January 2018

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Thresholds in development

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Construction of a genetic toggle switch in Escherichia coli

21 January 2018

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Reciprocal repression between Sox3 and snail transcription factors defines embryonic territories at gastrulation

21 January 2018

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A mechanism for the sharp transition of morphogen gradient interpretation in Xenopus

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Gene regulation by MAPK substrate competition.

21 January 2018

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The Drosophila gap gene network is composed of two parallel toggle switches

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Organization of developmental enhancers in the Drosophila embryo

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Whole-genome ChIP-chip analysis of Dorsal, Twist, and Snail suggests integration of diverse patterning processes in the Drosophila embryo

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A self-organizing system of repressor gradients establishes segmental complexity in Drosophila.

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21 January 2018

Identifiers

DOI

10.1002/WDEV.55

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18 March 2018

PubMed ID

23799569

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18 March 2018