(Q50920473)

25 March 2018

title

An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing. (English)

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25 March 2018

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Masahiro Onji

1

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25 March 2018

Atsuo Kanno

2

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25 March 2018

Shin-Ichiroh Saitoh

3

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25 March 2018

Ryutaro Fukui

4

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25 March 2018

Yuji Motoi

5

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25 March 2018

Takuma Shibata

6

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25 March 2018

Fumi Matsumoto

7

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25 March 2018

Aayam Lamichhane

8

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25 March 2018

Shintaro Sato

9

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25 March 2018

Hiroshi Kiyono

10

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25 March 2018

Kazuhide Yamamoto

11

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25 March 2018

Kensuke Miyake

12

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25 March 2018

language of work or name

English

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publication date

1 January 2013

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25 March 2018

published in

Nature Communications

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25 March 2018

volume

4

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25 March 2018

page(s)

1949

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25 March 2018

https://scigraph.springernature.com/pub.10.1038/ncomms2949

exact match

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cites work

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The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

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CpG motifs in bacterial DNA and their immune effects

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Immunologically active autoantigens: the role of toll-like receptors in the development of chronic inflammatory disease.

21 January 2018

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Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA.

21 January 2018

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Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide

21 January 2018

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Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

21 January 2018

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Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus

21 January 2018

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Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8.

21 January 2018

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UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes

21 January 2018

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TLR9 signals after translocating from the ER to CpG DNA in the lysosome

21 January 2018

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Transmembrane mutations in Toll-like receptor 9 bypass the requirement for ectodomain proteolysis and induce fatal inflammation.

21 January 2018

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The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor.

21 January 2018

1 reference

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Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS2949

Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS2949

Critical role for asparagine endopeptidase in endocytic Toll-like receptor signaling in dendritic cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS2949

A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS2949

The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS2949

Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells

21 January 2018

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Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing

21 January 2018

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The structural biology of Toll-like receptors

21 January 2018

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Identification of an N-terminal recognition site in TLR9 that contributes to CpG-DNA-mediated receptor activation

21 January 2018

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IRF-7 is the master regulator of type-I interferon-dependent immune responses

21 January 2018

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Ligand-induced conformational changes allosterically activate Toll-like receptor 9.

21 January 2018

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A protein associated with toll-like receptor 4 (PRAT4A) regulates cell surface expression of TLR4.

21 January 2018

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PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS2949

21 January 2018

Identifiers

DOI

10.1038/NCOMMS2949

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25 March 2018

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25 March 2018