(Q51030961)

27 March 2018

title

Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism. (English)

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27 March 2018

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K E Thummel

1

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27 March 2018

D O'Shea

2

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27 March 2018

M F Paine

3

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27 March 2018

D D Shen

4

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27 March 2018

K L Kunze

5

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27 March 2018

J D Perkins

6

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27 March 2018

G R Wilkinson

7

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27 March 2018

language of work or name

English

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publication date

1 May 1996

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27 March 2018

Clinical Pharmacology & Therapeutics

published in

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27 March 2018

volume

59

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27 March 2018

issue

5

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27 March 2018

page(s)

491-502

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27 March 2018

The immunocytochemical localisation and distribution of cytochrome P-450 in normal human hepatic and extrahepatic tissues with a monoclonal antibody to human cytochrome P-450

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Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes

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Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction

7 January 2021

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Characterization of midazolam metabolism using human hepatic microsomal fractions and hepatocytes in suspension obtained by perfusing whole human livers.

7 January 2021

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Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily.

7 January 2021

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Midazolam. A review of its pharmacological properties and therapeutic use.

7 January 2021

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Nonlinear binding of valproic acid (VPA) and E-delta 2-valproic acid to rat plasma proteins

7 January 2021

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Hepatic blood flow and drug metabolism in patients on enzyme-inducing anticonvulsants

7 January 2021

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The pharmacokinetics of midazolam in man.

7 January 2021

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First-pass elimination. Basic concepts and clinical consequences

7 January 2021

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7 January 2021

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Physiologic and temporal variation in hepatic elimination of midazolam.

7 January 2021

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Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of midazolam and its main metabolite alpha-hydroxymidazolam in healthy volunteers.

7 January 2021

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CYP3A gene expression in human gut epithelium

7 January 2021

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Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man

7 January 2021

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Presystemic elimination of drugs: theoretical considerations for quantifying the relative contribution of gut and liver

7 January 2021

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Noninvasive tests of CYP3A enzymes

7 January 2021

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Midazolam should be avoided in patients receiving the systemic antimycotics ketoconazole or itraconazole.

7 January 2021

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A potentially hazardous interaction between erythromycin and midazolam.

7 January 2021

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10.1016/S0009-9236(96)90177-0

7 January 2021

Identifiers

DOI

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27 March 2018

1 reference

27 March 2018