(Q51479338)

5 April 2018

title

Pore-blocking toxins as probes of voltage-dependent channels. (English)

1 reference

5 April 2018

author

Samuel C. Dudley

series ordinal

2

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5 April 2018

author name string

French RJ

series ordinal

1

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5 April 2018

language of work or name

English

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publication date

1 January 1999

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5 April 2018

published in

Methods in Enzymology

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5 April 2018

volume

294

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5 April 2018

page(s)

575-605

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5 April 2018

Structure and function of sodium channels

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A single point mutation confers tetrodotoxin and saxitoxin insensitivity on the sodium channel II.

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7 January 2021

Mapping the site of block by tetrodotoxin and saxitoxin of sodium channel II.

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7 January 2021

Molecular basis for pharmacological differences between brain and cardiac sodium channels.

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7 January 2021

On the structural basis for ionic selectivity among Na+, K+, and Ca2+ in the voltage-gated sodium channel

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7 January 2021

Altered ionic selectivity of the sodium channel revealed by cysteine mutations within the pore

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7 January 2021

P-loop flexibility in Na+ channel pores revealed by single- and double-cysteine replacements

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7 January 2021

A mutant of TTX-resistant cardiac sodium channels with TTX-sensitive properties

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7 January 2021

A mu-conotoxin-insensitive Na+ channel mutant: possible localization of a binding site at the outer vestibule

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7 January 2021

Mechanisms of sodium/calcium selectivity in sodium channels probed by cysteine mutagenesis and sulfhydryl modification

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7 January 2021

Single point mutations of the sodium channel drastically reduce the pore permeability without preventing its gating

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7 January 2021

Calcium channel characteristics conferred on the sodium channel by single mutations

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7 January 2021

Acetylcholine receptor channel structure probed in cysteine-substitution mutants.

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7 January 2021

Functional consequences of sulfhydryl modification in the pore-forming subunits of cardiovascular Ca2+ and Na+ channels.

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7 January 2021

Depth asymmetries of the pore-lining segments of the Na+ channel revealed by cysteine mutagenesis

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7 January 2021

Topology of the P segments in the sodium channel pore revealed by cysteine mutagenesis

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https://api.crossref.org/works/10.1016%2FS0076-6879%2899%2994033-8

7 January 2021

Molecular motions within the pore of voltage-dependent sodium channels

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https://api.crossref.org/works/10.1016%2FS0076-6879%2899%2994033-8

7 January 2021

Molecular aspects of ion permeation through channels

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https://api.crossref.org/works/10.1016%2FS0076-6879%2899%2994033-8

7 January 2021

Molecular basis of permeation in voltage-gated ion channels

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https://api.crossref.org/works/10.1016%2FS0076-6879%2899%2994033-8

7 January 2021

Chimeric study of sodium channels from rat skeletal and cardiac muscle

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https://api.crossref.org/works/10.1016%2FS0076-6879%2899%2994033-8

7 January 2021

Action of derivatives of mu-conotoxin GIIIA on sodium channels. Single amino acid substitutions in the toxin separately affect association and dissociation rates

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7 January 2021

A novel sodium channel inhibitor from Conus geographus: purification, structure, and pharmacological properties

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7 January 2021

Tertiary structure of conotoxin GIIIA in aqueous solution

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7 January 2021

Three-dimensional solution structure of mu-conotoxin GIIIB, a specific blocker of skeletal muscle sodium channels

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7 January 2021

Single sodium channels from rat brain incorporated into planar lipid bilayer membranes

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7 January 2021

Voltage-dependent block by saxitoxin of sodium channels incorporated into planar lipid bilayers

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7 January 2021

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7 January 2021

Voltage-dependent blockade of muscle Na+ channels by guanidinium toxins

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7 January 2021

Refined Structure of Charybdotoxin: Common Motifs in Scorpion Toxins and Insect Defensins

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7 January 2021

Analysis of side-chain organization on a refined model of charybdotoxin: structural and functional implications

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7 January 2021

Three-dimensional structure of natural charybdotoxin in aqueous solution by 1H-NMR. Charybdotoxin possesses a structural motif found in other scorpion toxins

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7 January 2021

Mapping function to structure in a channel-blocking peptide: electrostatic mutants of charybdotoxin.

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7 January 2021

Intimations of K+ channel structure from a complete functional map of the molecular surface of charybdotoxin

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7 January 2021

The charybdotoxin receptor of a Shaker K+ channel: peptide and channel residues mediating molecular recognition.

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7 January 2021

Mutant potassium channels with altered binding of charybdotoxin, a pore-blocking peptide inhibitor

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7 January 2021

Mapping the receptor site for charybdotoxin, a pore-blocking potassium channel inhibitor

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https://api.crossref.org/works/10.1016%2FS0076-6879%2899%2994033-8

7 January 2021

Mechanism of charybdotoxin block of the high-conductance, Ca2+-activated K+ channel

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7 January 2021

Interaction of charybdotoxin with permeant ions inside the pore of a K+ channel.

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7 January 2021

Mapping hydrophobic residues of the interaction surface of charybdotoxin

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7 January 2021

A strongly interacting pair of residues on the contact surface of charybdotoxin and a Shaker K+ channel.

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7 January 2021

A point mutation in a Shaker K+ channel changes its charybdotoxin binding site from low to high affinity.

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7 January 2021

Structure-activity relationships of mu-conotoxin GIIIA: structure determination of active and inactive sodium channel blocker peptides by NMR and simulated annealing calculations

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7 January 2021

Discrete Ba2+ block as a probe of ion occupancy and pore structure in the high-conductance Ca2+ -activated K+ channel

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7 January 2021

Potassium blocks barium permeation through a calcium-activated potassium channel

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7 January 2021

Modeling ion permeation through batrachotoxin-modified Na+ channels from rat skeletal muscle with a multi-ion pore

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7 January 2021

Diffusion-controlled binding of a peptide neurotoxin to its potassium channel receptor

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7 January 2021

Differential effects of sulfhydryl reagents on saxitoxin and tetrodotoxin block of voltage-dependent Na channels

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7 January 2021

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7 January 2021

Synthesis and characterization of mu-conotoxin IIIa

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7 January 2021

Synthesis and characterization of an N-terminal-specific 125I-photoaffinity derivative of mu-Conotoxin GIIIA which binds to the voltage-dependent sodium channel.

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7 January 2021

Tetrodotoxin receptors in plasma membranes isolated from lobster nerve fibers.

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7 January 2021

The binding of labelled tetrodotoxin to non-myelinated nerve fibres.

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7 January 2021

The binding of labelled saxitoxin to the sodium channels in nerve membranes

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7 January 2021

Isochannels and blocking modes of voltage-dependent sodium channels.

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7 January 2021

Kinetics of TTX-STX block of sodium channels.

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7 January 2021

The rates of saxitoxin action and of saxitoxin-tetrodotoxin interaction at the node of Ranvier

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7 January 2021

Contribution of sialic acid to the voltage dependence of sodium channel gating. A possible electrostatic mechanism

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7 January 2021

The aromatic binding site for tetraethylammonium ion on potassium channels

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7 January 2021

A mechanism for ion selectivity in potassium channels: computational studies of cation-pi interactions

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7 January 2021

Silver as a probe of pore-forming residues in a potassium channel

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7 January 2021

Mutations affecting TEA blockade and ion permeation in voltage-activated K+ channels

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2899%2994033-8

7 January 2021

Post-repolarization block of cloned sodium channels by saxitoxin: the contribution of pore-region amino acids

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7 January 2021

Acetylcholine binding by a synthetic receptor: implications for biological recognition

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https://api.crossref.org/works/10.1016%2FS0076-6879%2899%2994033-8

7 January 2021

Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp

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7 January 2021

High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis

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https://api.crossref.org/works/10.1016%2FS0076-6879%2899%2994033-8

7 January 2021

Molecular determinants of state-dependent block of Na+ channels by local anesthetics

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7 January 2021

A critical role for transmembrane segment IVS6 of the sodium channel alpha subunit in fast inactivation

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7 January 2021

Rapid and efficient site-specific mutagenesis without phenotypic selection

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7 January 2021

Rapid site-directed mutagenesis by a method that selects for full length mutated DNA.

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https://api.crossref.org/works/10.1016%2FS0076-6879%2899%2994033-8

7 January 2021

A method for the site-directed mono- and multi-mutagenesis of double-stranded DNA.

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https://api.crossref.org/works/10.1016%2FS0076-6879%2899%2994033-8

7 January 2021

Topology of the pore-region of a K+ channel revealed by the NMR-derived structures of scorpion toxins

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https://api.crossref.org/works/10.1016%2FS0076-6879%2899%2994033-8

7 January 2021

Spatial localization of the K+ channel selectivity filter by mutant cycle-based structure analysis.

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https://api.crossref.org/works/10.1016%2FS0076-6879%2899%2994033-8

7 January 2021

Revealing the architecture of a K+ channel pore through mutant cycles with a peptide inhibitor.

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https://api.crossref.org/works/10.1016%2FS0076-6879%2899%2994033-8

7 January 2021

The folding of an enzyme. I. Theory of protein engineering analysis of stability and pathway of protein folding

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7 January 2021

Strategy for analysing the co-operativity of intramolecular interactions in peptides and proteins

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https://api.crossref.org/works/10.1016%2FS0076-6879%2899%2994033-8

7 January 2021

Strength and co-operativity of contributions of surface salt bridges to protein stability

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7 January 2021

Estimating the contribution of engineered surface electrostatic interactions to protein stability by using double-mutant cycles

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https://api.crossref.org/works/10.1016%2FS0076-6879%2899%2994033-8

7 January 2021

The signature sequence of voltage-gated potassium channels projects into the external vestibule

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https://api.crossref.org/works/10.1016%2FS0076-6879%2899%2994033-8

7 January 2021

On the choice of reference mutant states in the application of the double-mutant cycle method

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https://api.crossref.org/works/10.1016%2FS0076-6879%2899%2994033-8

7 January 2021

Fine structure-activity analysis of mutations at position 51 of tyrosyl-tRNA synthetase

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https://api.crossref.org/works/10.1016%2FS0076-6879%2899%2994033-8

7 January 2021

Mapping the transition state and pathway of protein folding by protein engineering

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https://api.crossref.org/works/10.1016%2FS0076-6879%2899%2994033-8

7 January 2021

Classical electrostatics in biology and chemistry

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7 January 2021

Empirical Predictions of Protein Conformation

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https://api.crossref.org/works/10.1016%2FS0076-6879%2899%2994033-8

7 January 2021

A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel

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https://api.crossref.org/works/10.1016%2FS0076-6879%2899%2994033-8

7 January 2021

Solvation, water permeation, and ionic selectivity of a putative model for the pore region of the voltage-gated sodium channel.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2899%2994033-8

7 January 2021

Predominant interactions between mu-conotoxin Arg-13 and the skeletal muscle Na+ channel localized by mutant cycle analysis.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2899%2994033-8

7 January 2021

The action of calcium on the electrical properties of squid axons.

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https://api.crossref.org/works/10.1016%2FS0076-6879%2899%2994033-8

7 January 2021

Negative surface charge near sodium channels of nerve: divalent ions, monovalent ions, and pH

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https://api.crossref.org/works/10.1016%2FS0076-6879%2899%2994033-8

7 January 2021

Simple shifts in the voltage dependence of sodium channel gating caused by divalent cations

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2899%2994033-8

7 January 2021

Effects of membrane surface charge and calcium on the gating of rat brain sodium channels in planar bilayers

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2899%2994033-8

7 January 2021

The receptor for tetrodotoxin and saxitoxin. A structural hypothesis

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2899%2994033-8

7 January 2021

μl Na+ channels expressed transiently in human embryonic kidney cells: Biochemical and biophysical properties

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2899%2994033-8

7 January 2021

Diversity of Conus neuropeptides

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2899%2994033-8

7 January 2021

Calcium channel diversity and neurotransmitter release: the omega-conotoxins and omega-agatoxins

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2899%2994033-8

7 January 2021

A new family of conotoxins that blocks voltage-gated sodium channels

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2899%2994033-8

7 January 2021

An inhibitor of the Kv2.1 potassium channel isolated from the venom of a Chilean tarantula

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2899%2994033-8

7 January 2021

Block of Ca channels in rat central neurons by the spider toxin omega-Aga-IIIA.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2899%2994033-8

7 January 2021

Molecular properties of a superfamily of plasma-membrane cation channels

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2899%2994033-8

7 January 2021

10.1016/S0076-6879(99)94033-8

Identifiers

DOI

1 reference

5 April 2018

1 reference

5 April 2018