(Q51529943)

6 April 2018

title

A multiple-dose toxicity study of tanezumab in cynomolgus monkeys. (English)

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6 April 2018

author name string

Mark Zorbas

1

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6 April 2018

Susan Hurst

2

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6 April 2018

David Shelton

3

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6 April 2018

Mark Evans

4

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6 April 2018

Deborah Finco

5

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6 April 2018

Mark Butt

6

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6 April 2018

language of work or name

English

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publication date

3 December 2010

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6 April 2018

Regulatory Toxicology and Pharmacology

published in

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6 April 2018

volume

59

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6 April 2018

issue

2

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6 April 2018

page(s)

334-342

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6 April 2018

Probing the binding mechanism and affinity of tanezumab, a recombinant humanized anti-NGF monoclonal antibody, using a repertoire of biosensors

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A study of the de- and regenerative changes in the sympathetic nervous system of the adult mouse after treatment with the antiserum to nerve growth factor

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Incidences and range of spontaneous findings in control cynomolgus monkeys (Macaca fascicularis) used in toxicity studies

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PURIFICATION OF A NERVE-GROWTH PROMOTING PROTEIN FROM THE MOUSE SALIVARY GLAND AND ITS NEURO-CYTOTOXIC ANTISERUM.

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Effects of long-term nerve growth factor deprivation on the nervous system of the adult rat: An experimental autoimmune approach

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A blocking antibody to nerve growth factor attenuates skeletal pain induced by prostate tumor cells growing in bone.

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Novel class of pain drugs based on antagonism of NGF.

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Nerve growth factor sequestering therapy attenuates non-malignant skeletal pain following fracture

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Destruction of sympathetic and sensory neurons in the developing rat by a monoclonal antibody against the nerve growth factor (NGF) receptor

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Effects of a monoclonal antibody raised against nerve growth factor on skeletal pain and bone healing after fracture of the C57BL/6J mouse femur

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Tanezumab for the treatment of pain from osteoarthritis of the knee.

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DESTRUCTION OF THE SYMPATHETIC GANGLIA IN MAMMALS BY AN ANTISERUM TO A NERVE-GROWTH PROTEIN.

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The biological effects of endogenous nerve growth factor on adult sensory neurons revealed by a trkA-IgG fusion molecule

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Use of an experimental autoimmune model to define nerve growth factor dependency of peripheral and central substance P-containing neurons in the rat

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Anti-NGF therapy profoundly reduces bone cancer pain and the accompanying increase in markers of peripheral and central sensitization

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Nerve growth factor mediates hyperalgesia and cachexia in auto-immune arthritis.

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Targeting nerve growth factor in pain: what is the therapeutic potential?

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Nerve growth factor contributes to the generation of inflammatory sensory hypersensitivity.

7 January 2021

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10.1016/J.YRTPH.2010.11.005

7 January 2021

Identifiers

DOI

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6 April 2018

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6 April 2018