(Q51659532)

9 April 2018

title

Molecular Insights into the Thermal Stability of mAbs with Variable-Temperature Ion-Mobility Mass Spectrometry. (English)

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author

Perdita Barran

7

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author name string

Kamila J Pacholarz

1

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Shirley J Peters

2

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Rachel A Garlish

3

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Alistair J Henry

4

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Richard J Taylor

5

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David P Humphreys

6

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publication date

4 November 2015

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9 April 2018

published in

ChemBioChem

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volume

17

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issue

1

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page(s)

46-51

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Selecting and screening recombinant antibody libraries

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Stability improvement of antibodies for extracellular and intracellular applications: CDR grafting to stable frameworks and structure-based framework engineering

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Introduction to current and future protein therapeutics: a protein engineering perspective

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Influence of pH on heat-induced aggregation and degradation of therapeutic monoclonal antibodies.

21 January 2018

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Increased aggregation propensity of IgG2 subclass over IgG1: role of conformational changes and covalent character in isolated aggregates

21 January 2018

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Effects of protein aggregates: an immunologic perspective

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201500574

Anti-Inflammatory Activity of Human IgG4 Antibodies by Dynamic Fab Arm Exchange

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201500574

Species-Specific Determinants in the IgG CH3 Domain Enable Fab-Arm Exchange by Affecting the Noncovalent CH3-CH3 Interaction Strength

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500574

Engineering an improved IgG4 molecule with reduced disulfide bond heterogeneity and increased Fab domain thermal stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500574

The thermal stability of immunoglobulin: unfolding and aggregation of a multi-domain protein

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201500574

Equilibrium and kinetics of the denaturation of a homogeneous human immunoglobulin light chain.

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201500574

An intermediate pH unfolding transition abrogates the ability of IgE to interact with its high affinity receptor FcepsilonRIalpha.

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201500574

Contribution of variable domains to the stability of humanized IgG1 monoclonal antibodies.

21 January 2018

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A broad range of Fab stabilities within a host of therapeutic IgGs.

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201500574

Stability of monoclonal antibodies at high-concentration: head-to-head comparison of the IgG1 and IgG4 subclass

21 January 2018

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Innovative native MS methodologies for antibody drug conjugate characterization: High resolution native MS and IM-MS for average DAR and DAR distribution assessment.

21 January 2018

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The role of ion mobility spectrometry-mass spectrometry in the analysis of protein reference standards.

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201500574

Insights into the conformations of three structurally diverse proteins: cytochrome c, p53, and MDM2, provided by variable-temperature ion mobility mass spectrometry

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201500574

Distinguishing Loss of Structure from Subunit Dissociation for Protein Complexes with Variable Temperature Ion Mobility Mass Spectrometry

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201500574

Dynamics of inter-heavy chain interactions in human immunoglobulin G (IgG) subclasses studied by kinetic Fab arm exchange.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500574

Crystal structure of the human IgG4 C(H)3 dimer reveals the role of Arg409 in the mechanism of Fab-arm exchange

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201500574

Structural Determinants of Unique Properties of Human IgG4-Fc

21 January 2018

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Impact of deglycosylation and thermal stress on conformational stability of a full length murine IgG2a monoclonal antibody: observations from molecular dynamics simulations

21 January 2018

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Dynamics of Intact Immunoglobulin G Explored by Drift-Tube Ion-Mobility Mass Spectrometry and Molecular Modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500574

Dynamics of Intact Immunoglobulin G Explored by Drift-Tube Ion-Mobility Mass Spectrometry and Molecular Modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500574

The effect of salt on the conformations of three model proteins is revealed by variable temperature ion mobility mass spectrometry

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201500574

21 January 2018

Identifiers

DOI

10.1002/CBIC.201500574

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9 April 2018

PubMed ID

26534882

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9 April 2018