(Q51689139)

9 April 2018

title

Clinical Trials, Triumphs, and Tribulations of Glucagon Receptor Antagonists (English)

1 reference

9 April 2018

1 reference

Mackenzie J Pearson

1

1 reference

9 April 2018

Roger H Unger

series ordinal

2

1 reference

9 April 2018

William L Holland

series ordinal

3

1 reference

9 April 2018

language of work or name

English

0 references

publication date

1 July 2016

1 reference

9 April 2018

published in

Diabetes Care

1 reference

9 April 2018

volume

39

1 reference

9 April 2018

issue

7

1 reference

9 April 2018

page(s)

1075-1077

1 reference

9 April 2018

Glucagon receptor antagonism induces increased cholesterol absorption

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5876017

Recent progress in the development of small-molecule glucagon receptor antagonists

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5876017

Glucagon Couples Hepatic Amino Acid Catabolism to mTOR-Dependent Regulation of α-Cell Mass

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5876017

Glucagon receptor antibody completely suppresses type 1 diabetes phenotype without insulin by disrupting a novel diabetogenic pathway

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5876017

Metabolic manifestations of insulin deficiency do not occur without glucagon action

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5876017

Brain glucose sensing and neural regulation of insulin and glucagon secretion

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5876017

Dual elimination of the glucagon and GLP-1 receptors in mice reveals plasticity in the incretin axis

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5876017

CREB and the CRTC co-activators: sensors for hormonal and metabolic signals

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5876017

Insulin modulation of glucagon secretion: the role of insulin and other factors in the regulation of glucagon secretion

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5876017

Paracrinology of islets and the paracrinopathy of diabetes

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5876017

Pancreatic Extracts in the Treatment of Diabetes Mellitus

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5876017

Insulin signaling in alpha cells modulates glucagon secretion in vivo

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5876017

Quantitative aspects of the reaction between insulin and insulin-binding antibody

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5876017

Insulin within islets is a physiologic glucagon release inhibitor

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5876017

Glucagon-stimulating activity of 20 amino acids in dogs

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5876017

Identification of glucagon in the gastrointestinal tract

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5876017

Evaluation of Efficacy and Safety of the Glucagon Receptor Antagonist LY2409021 in Patients With Type 2 Diabetes: 12- and 24-Week Phase 2 Studies

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5876017

Short-term administration of the glucagon receptor antagonist LY2409021 lowers blood glucose in healthy people and in those with type 2 diabetes

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5876017

Glucagon receptor antagonist-mediated improvements in glycemic control are dependent on functional pancreatic GLP-1 receptor

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5876017

Purification and crystallization of glucagon

14 August 2018

1 reference

12 December 2020

Fibroblast growth factor 21 (FGF21) and glucagon-like peptide 1 contribute to diabetes resistance in glucagon receptor-deficient mice

1 reference

12 December 2020

Glucagon antibodies and their use for immunoassay for glucagon

1 reference

12 December 2020

Hyperglucagonemia and its suppression. Importance in the metabolic control of diabetes

1 reference

12 December 2020

Identifiers

DOI

10.2337/DCI15-0033

1 reference

9 April 2018

PMC publication ID

5876017

1 reference

9 April 2018

PubMed publication ID

27330122

1 reference

9 April 2018