(Q51695191)

9 April 2018

title

A computational model of Purkinje fibre single cell electrophysiology: implications for the long QT syndrome. (English)

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9 April 2018

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K J Sampson

1

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9 April 2018

V Iyer

series ordinal

2

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9 April 2018

A R Marks

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3

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9 April 2018

R S Kass

series ordinal

4

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9 April 2018

language of work or name

English

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publication date

24 May 2010

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9 April 2018

published in

Journal of Physiology

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9 April 2018

volume

588

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9 April 2018

issue

Pt 14

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9 April 2018

page(s)

2643-2655

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9 April 2018

Cardiac cell modelling: observations from the heart of the cardiac physiome project

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Optimal velocity and safety of discontinuous conduction through the heterogeneous Purkinje-ventricular junction.

25 August 2018

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Mathematical models of the electrical action potential of Purkinje fibre cells.

25 August 2018

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Modelling and measuring electromechanical coupling in the rat heart.

25 August 2018

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The Purkinje cell; 2008 style

25 August 2018

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Modeling of the adrenergic response of the human IKs current (hKCNQ1/hKCNE1) stably expressed in HEK-293 cells

25 August 2018

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Genesis and regulation of the heart automaticity.

25 August 2018

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Ionic mechanisms of endogenous bursting in CA3 hippocampal pyramidal neurons: a model study

25 August 2018

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The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel

25 August 2018

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Comparison of guinea-pig ventricular myocytes and dog Purkinje fibres for in vitro assessment of drug-induced delayed repolarization

25 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916994

Expression of skeletal muscle Na(V)1.4 Na channel isoform in canine cardiac Purkinje myocytes.

25 August 2018

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Comparison of K+ currents in cardiac Purkinje cells isolated from rabbit and dog.

25 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916994

Altered Na+ channels promote pause-induced spontaneous diastolic activity in long QT syndrome type 3 myocytes

25 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916994

A slowly inactivating sodium current (INa2) in the plateau range in canine cardiac Purkinje single cells

25 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916994

Pharmacogenetics and anti-arrhythmic drug therapy: a theoretical investigation

25 August 2018

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Restitution of Ca(2+) release and vulnerability to arrhythmias

25 August 2018

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Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart

25 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916994

Contribution of neuronal sodium channels to the cardiac fast sodium current INa is greater in dog heart Purkinje fibers than in ventricles

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916994

A computational model of the human left-ventricular epicardial myocyte

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916994

Theoretical investigation of the neuronal Na+ channel SCN1A: abnormal gating and epilepsy

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916994

Mapping and ablation of ventricular fibrillation associated with long-QT and Brugada syndromes

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916994

An unexpected requirement for brain-type sodium channels for control of heart rate in the mouse sinoatrial node

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916994

Insights into the molecular mechanisms of bradycardia-triggered arrhythmias in long QT-3 syndrome

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916994

Properties of potassium currents in Purkinje cells of failing human hearts

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916994

Na(+) channel mutation that causes both Brugada and long-QT syndrome phenotypes: a simulation study of mechanism

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916994

Molecular interactions between two long-QT syndrome gene products, HERG and KCNE2, rationalized by in vitro and in silico analysis

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916994

Integrated allosteric model of voltage gating of HCN channels

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916994

Slow delayed rectifier current and repolarization in canine cardiac Purkinje cells

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916994

Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias.

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916994

Na(+) current contribution to the diastolic depolarization in newborn rabbit SA node cells.

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916994

Action potential and contractility changes in [Na(+)](i) overloaded cardiac myocytes: a simulation study

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916994

Ca(2+) transients and Ca(2+) waves in purkinje cells : role in action potential initiation

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916994

Pause induced early afterdepolarizations in the long QT syndrome: a simulation study

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916994

Comparison of the cellular electrophysiological characteristics of canine left ventricular epicardium, M cells, endocardium and Purkinje fibres.

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916994

Both T- and L-type Ca2+ channels can contribute to excitation-contraction coupling in cardiac Purkinje cells

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916994

The newborn rabbit sino-atrial node expresses a neuronal type I-like Na+ channel.

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916994

SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916994

Molecular mechanism for an inherited cardiac arrhythmia

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916994

Cycle length-dependent action potential duration in canine cardiac Purkinje fibers.

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916994

Antiadrenergic effects of adenosine on His-Purkinje automaticity. Evidence for accentuated antagonism

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916994

A model of cardiac electrical activity incorporating ionic pumps and concentration changes

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916994

Rate and concentration-dependent effects of UK-68,798, a potent new class III antiarrhythmic, on canine Purkinje fibre action potential duration and Vmax

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916994

Effect of tetrodotoxin on action potentials of the conducting system in the dog heart

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916994

Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia

25 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2010.187328

The role of the delayed rectifier component IKs in dog ventricular muscle and Purkinje fibre repolarization

21 January 2018

1 reference

12 December 2020

Role of the calcium-independent transient outward current I(to1) in shaping action potential morphology and duration

1 reference

12 December 2020

Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death

1 reference

12 December 2020

Ionic remodeling of cardiac Purkinje cells by congestive heart failure

1 reference

12 December 2020

Comparison of ion-channel subunit expression in canine cardiac Purkinje fibers and ventricular muscle

1 reference

12 December 2020

Postextrasystolic alterations in refractoriness of the His-Purkinje system and ventricular myocardium in man

1 reference

12 December 2020

L- and T-type Ca2+ channels in canine cardiac Purkinje cells. Single-channel demonstration of L-type Ca2+ window current

1 reference

12 December 2020

Transient Outward Currents in Subendocardial Purkinje Myocytes Surviving in the Infarcted Heart

1 reference

12 December 2020

Electrophysiologic effects of acute myocardial ischemia. A mechanistic investigation of action potential conduction and conduction failure

1 reference

12 December 2020

Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, II: model studies

1 reference

12 December 2020

Molecular basis of the T- and L-type Ca2+ currents in canine Purkinje fibres

1 reference

12 December 2020

Regional and tissue specific transcript signatures of ion channel genes in the non-diseased human heart

1 reference

12 December 2020

A reduced differential model of the electrical activity of cardiac Purkinje fibres

1 reference

12 December 2020

10.1113/JPHYSIOL.2010.187328

Identifiers

DOI

1 reference

9 April 2018

PMC publication ID

2916994

0 references

1 reference

9 April 2018