(Q51750613)

11 April 2018

review article

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title

Malonyl CoA: A promising target for the treatment of cardiac disease. (English)

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11 April 2018

author name string

Natasha Fillmore

series ordinal

1

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11 April 2018

Gary D Lopaschuk

series ordinal

2

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11 April 2018

publication date

3 March 2014

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11 April 2018

published in

IUBMB Life

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11 April 2018

Myocardial fatty acid metabolism in health and disease

cites work

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A role for peroxisome proliferator-activated receptor alpha (PPARalpha ) in the control of cardiac malonyl-CoA levels: reduced fatty acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking PPARalpha are associated wi

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Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity.

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Moderate severity heart failure does not involve a downregulation of myocardial fatty acid oxidation

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Peroxisomal-proliferator-activated receptor alpha activates transcription of the rat hepatic malonyl-CoA decarboxylase gene: a key regulation of malonyl-CoA level

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Effects of metabolic modulation by trimetazidine on left ventricular function and phosphocreatine/adenosine triphosphate ratio in patients with heart failure

21 January 2018

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A randomized clinical trial of trimetazidine, a partial free fatty acid oxidation inhibitor, in patients with heart failure

21 January 2018

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Metabolic modulation with perhexiline in chronic heart failure: a randomized, controlled trial of short-term use of a novel treatment

21 January 2018

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Discovery of potent and orally available malonyl-CoA decarboxylase inhibitors as cardioprotective agents.

21 January 2018

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Synthesis and structure-activity relationship of small-molecule malonyl coenzyme A decarboxylase inhibitors

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IUB.1253

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11 April 2018

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11 April 2018