(Q51778118)

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N6-isopentenyladenosine improves nuclear shape in fibroblasts from humans with progeroid syndromes by inhibiting the farnesylation of prelamin A.

scientific article published on 18 November 2013

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Europe PubMed Central

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27 February 2020

N6-isopentenyladenosine improves nuclear shape in fibroblasts from humans with progeroid syndromes by inhibiting the farnesylation of prelamin A (English)

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Europe PubMed Central

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27 February 2020

Maurizio Bifulco

1

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27 February 2020

Simona Paladino

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27 February 2020

Anna Maria Malfitano

4

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27 February 2020

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Alba D'Alessandro

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27 February 2020

Maria Notarnicola

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27 February 2020

Maria G Caruso

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27 February 2020

Chiara Laezza

7

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27 February 2020

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18 November 2013

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27 February 2020

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27 February 2020

280

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27 February 2020

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27 February 2020

6223-6232

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27 February 2020

LMNA is mutated in Hutchinson-Gilford progeria (MIM 176670) but not in Wiedemann-Rautenstrauch progeroid syndrome (MIM 264090).

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12544

21 January 2018

Lamin a truncation in Hutchinson-Gilford progeria.

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12544

21 January 2018

Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12544

21 January 2018

Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12544

21 January 2018

Hutchinson-Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12544

21 January 2018

Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12544

21 January 2018

Genomic instability in laminopathy-based premature aging

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12544

21 January 2018

Lamin A, farnesylation and aging

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12544

21 January 2018

Molecular ageing in progeroid syndromes: Hutchinson-Gilford progeria syndrome as a model

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12544

21 January 2018

Phenotype and course of Hutchinson-Gilford progeria syndrome

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12544

21 January 2018

Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12544

21 January 2018

Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12544

21 January 2018

A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria.

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12544

21 January 2018

Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging.

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12544

21 January 2018

Targeting protein prenylation in progeria

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12544

21 January 2018

Clinical trial of a farnesyltransferase inhibitor in children with Hutchinson-Gilford progeria syndrome

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12544

21 January 2018

Progeria: translational insights from cell biology

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12544

21 January 2018

Biological and pharmacological roles of N6-isopentenyladenosine: an emerging anticancer drug

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12544

21 January 2018

N6-isopentenyladenosine inhibits cell proliferation and induces apoptosis in a human colon cancer cell line DLD1.

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12544

21 January 2018

Involvement of Akt/NF-κB pathway in N6-isopentenyladenosine-induced apoptosis in human breast cancer cells.

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12544

21 January 2018

N6-isopentenyladenosine arrests tumor cell proliferation by inhibiting farnesyl diphosphate synthase and protein prenylation

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12544

21 January 2018

Regulation of the mevalonate pathway

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12544

21 January 2018

Farnesyl pyrophosphate synthase: a key enzyme in isoprenoid biosynthetic pathway and potential molecular target for drug development

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12544

21 January 2018

v-K-ras leads to preferential farnesylation of p21(ras) in FRTL-5 cells: multiple interference with the isoprenoid pathway

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12544

21 January 2018

Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation.

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12544

21 January 2018

Distinct structural and mechanical properties of the nuclear lamina in Hutchinson-Gilford progeria syndrome

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12544

21 January 2018

Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12544

21 January 2018

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12544

21 January 2018

Identifiers

10.1111/FEBS.12544

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24112551%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24112551%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

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