(Q51787521)

12 April 2018

title

Structure-guided optimization of the interleukin-6 trans-signaling antagonist sgp130. (English)

1 reference

12 April 2018

author

Stefan Rose-John

7

1 reference

12 April 2018

author name string

Stephanie Tenhumberg

1

1 reference

12 April 2018

Georg H Waetzig

2

1 reference

12 April 2018

Athena Chalaris

3

1 reference

12 April 2018

Björn Rabe

4

1 reference

12 April 2018

Dirk Seegert

5

1 reference

12 April 2018

Jürgen Scheller

6

1 reference

12 April 2018

Joachim Grötzinger

8

1 reference

12 April 2018

language of work or name

English

0 references

publication date

23 July 2008

1 reference

12 April 2018

Journal of Biological Chemistry

published in

1 reference

12 April 2018

volume

283

1 reference

12 April 2018

page(s)

27200-27207

1 reference

12 April 2018

issue

40

1 reference

12 April 2018

Molecular cloning and expression of an IL-6 signal transducer, gp130

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803694200

Principles of interleukin (IL)-6-type cytokine signalling and its regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803694200

Interleukin 6 is required for the development of collagen-induced arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803694200

IL-6-deficient mice are resistant to the induction of experimental autoimmune encephalomyelitis provoked by myelin oligodendrocyte glycoprotein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803694200

Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803694200

Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803694200

Soluble receptors for cytokines and growth factors: generation and biological function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803694200

Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803694200

Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803694200

Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: a multicenter, double-blind, placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803694200

Design of effective immunotherapy for human autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803694200

A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803694200

Structure of an extracellular gp130 cytokine receptor signaling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803694200

Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803694200

Dynamics of the gp130 cytokine complex: a model for assembly on the cellular membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803694200

A role for the immunoglobulin-like domain of the human IL-6 receptor. Intracellular protein transport and shedding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803694200

Receptor recognition sites of cytokines are organized as exchangeable modules. Transfer of the leukemia inhibitory factor receptor-binding site from ciliary neurotrophic factor to interleukin-6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803694200

The family of the IL-6-type cytokines: specificity and promiscuity of the receptor complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803694200

WHAT IF: a molecular modeling and drug design program

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803694200

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803694200

IL-6 type cytokine receptor complexes: hexamer, tetramer or both?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803694200

Shared cytokine signaling receptors: structural insights from the gp130 system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803694200

TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803694200

Kinetics of protein-protein association explained by Brownian dynamics computer simulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803694200

Blockade of interleukin 6 trans signaling suppresses T-cell resistanceagainst apoptosis in chronic intestinal inflammation: Evidence in Crohn diseaseand experimental colitis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803694200

21 January 2018

Identifiers

DOI

10.1074/JBC.M803694200

1 reference

12 April 2018

PubMed ID

18650419

1 reference

12 April 2018