(Q51796409)

English

XRCC1 down-regulation in human cells leads to DNA-damaging agent hypersensitivity, elevated sister chromatid exchange, and reduced survival of BRCA2 mutant cells.

scientific article published in July 2007

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scholarly article

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/17603793

XRCC1 down-regulation in human cells leads to DNA-damaging agent hypersensitivity, elevated sister chromatid exchange, and reduced survival of BRCA2 mutant cells. (English)

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/17603793

author name string

Jinshui Fan

1

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/17603793

Paul F Wilson

2

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/17603793

Heng-Kuan Wong

3

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/17603793

Salustra S Urbin

4

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/17603793

Larry H Thompson

5

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/17603793

David M Wilson

6

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/17603793

publication date

1 July 2007

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/17603793

Environmental and Molecular Mutagenesis

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/17603793

48

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/17603793

491-500

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/17603793

6

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/17603793

The CHO XRCC1 mutant, EM9, deficient in DNA ligase III activity, exhibits hypersensitivity to camptothecin independent of DNA replication

1 reference

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21 January 2018

A mammalian cell line deficient in activity of the DNA repair enzyme 5-hydroxymethyluracil-DNA glycosylase is resistant to the toxic effects of the thymidine analog 5-hydroxymethyl-2'-deoxyuridine

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

21 January 2018

Cross-sensitivity of gamma-ray-sensitive hamster mutants to cross-linking agents

1 reference

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21 January 2018

An interaction between the mammalian DNA repair protein XRCC1 and DNA ligase III

1 reference

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21 January 2018

Cell cycle checkpoint function in bladder cancer

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

21 January 2018

A high yield of translocations parallels the high yield of sister chromatid exchanges in the CHO mutant EM9.

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

21 January 2018

Poly(ADP-ribose) polymerase (PARP-1) in homologous recombination and as a target for cancer therapy

1 reference

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21 January 2018

ATM signaling and genomic stability in response to DNA damage

1 reference

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21 January 2018

A CHO-cell strain having hypersensitivity to mutagens, a defect in DNA strand-break repair, and an extraordinary baseline frequency of sister-chromatid exchange

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

21 January 2018

Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

21 January 2018

XRCC1 keeps DNA from getting stranded

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

21 January 2018

Molecular mechanisms of sister-chromatid exchange

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

21 January 2018

Double-strand break repair deficiency and radiation sensitivity in BRCA2 mutant cancer cells

1 reference

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7 January 2021

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The PARP superfamily

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining.

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

7 January 2021

based on heuristic

inferred from DOI database lookup

Reduced ligation during DNA base excision repair supported by BRCA2 mutant cells

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

7 January 2021

based on heuristic

inferred from DOI database lookup

Definitive identification of mammalian 5-hydroxymethyluracil DNA N-glycosylase activity as SMUG1

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

7 January 2021

based on heuristic

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XRCC1 is required for DNA single-strand break repair in human cells

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

7 January 2021

based on heuristic

inferred from DOI database lookup

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of the XRCC1-DNA ligase III complex in vitro and its absence from mutant hamster cells

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

7 January 2021

based on heuristic

inferred from DOI database lookup

Involvement of XRCC1 and DNA ligase III gene products in DNA base excision repair.

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

7 January 2021

based on heuristic

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Cancer in xeroderma pigmentosum and related disorders of DNA repair

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

7 January 2021

based on heuristic

inferred from DOI database lookup

XRCC1 co-localizes and physically interacts with PCNA

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein-protein interactions and posttranslational modifications in mammalian base excision repair

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

7 January 2021

based on heuristic

inferred from DOI database lookup

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

7 January 2021

based on heuristic

inferred from DOI database lookup

The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

7 January 2021

based on heuristic

inferred from DOI database lookup

Hypersensitivity of DNA polymerase beta null mouse fibroblasts reflects accumulation of cytotoxic repair intermediates from site-specific alkyl DNA lesions

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

7 January 2021

based on heuristic

inferred from DOI database lookup

Poly(ADP-ribose) polymerase activity prevents signaling pathways for cell cycle arrest after DNA methylating agent exposure.

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

7 January 2021

based on heuristic

inferred from DOI database lookup

Spontaneous sister chromatid exchanges detected by a BUdR-labelling method

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

7 January 2021

based on heuristic

inferred from DOI database lookup

Independent roles of XRCC1's two BRCT motifs in recovery from methylation damage

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

7 January 2021

based on heuristic

inferred from DOI database lookup

Mouse models of XRCC1 DNA repair polymorphisms and cancer

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

7 January 2021

based on heuristic

inferred from DOI database lookup

XRCC1 is phosphorylated by DNA-dependent protein kinase in response to DNA damage

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

7 January 2021

based on heuristic

inferred from DOI database lookup

A new XRCC1-containing complex and its role in cellular survival of methyl methanesulfonate treatment

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

7 January 2021

based on heuristic

inferred from DOI database lookup

Isolation of a small molecule inhibitor of DNA base excision repair.

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

7 January 2021

based on heuristic

inferred from DOI database lookup

BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of Poly (ADP-Ribose) polymerase: an issue of potency

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

7 January 2021

based on heuristic

inferred from DOI database lookup

Chromosome instability and tumor predisposition inversely correlate with BLM protein levels

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

7 January 2021

based on heuristic

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Cytogenetic biomarkers and genetic polymorphisms

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

7 January 2021

based on heuristic

inferred from DOI database lookup

The role of chromosomal instability in tumor initiation

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

7 January 2021

based on heuristic

inferred from DOI database lookup

XRCC1 genotype and breast cancer: functional studies and epidemiologic data show interactions between XRCC1 codon 280 His and smoking

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

7 January 2021

based on heuristic

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Roles of DNA ligase III and XRCC1 in regulating the switch between short patch and long patch BER.

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

7 January 2021

based on heuristic

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Micronuclei in EM9 cells expressing polymorphic forms of human XRCC1.

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

7 January 2021

based on heuristic

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X-ray repair cross-complementing group 1 polymorphisms and cancer risks in Asian populations: a mini review

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

7 January 2021

based on heuristic

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Aging and sister chromatid exchange. VI. The effect of in vitro passage on spontaneous SCE frequencies in human fetal lung fibroblast cultures

1 reference

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7 January 2021

based on heuristic

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Mutations in hamster single-strand break repair gene XRCC1 causing defective DNA repair

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

7 January 2021

based on heuristic

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Molecular pathogenesis of Fanconi anemia: recent progress

1 reference

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7 January 2021

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Chromosome instability syndromes

1 reference

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7 January 2021

based on heuristic

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A cell cycle-specific requirement for the XRCC1 BRCT II domain during mammalian DNA strand break repair

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Central role for the XRCC1 BRCT I domain in mammalian DNA single-strand break repair

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

7 January 2021

based on heuristic

inferred from DOI database lookup

Requirement for the Xrcc1 DNA base excision repair gene during early mouse development

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

7 January 2021

based on heuristic

inferred from DOI database lookup

Rescue of Xrcc1 knockout mouse embryo lethality by transgene-complementation.

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

7 January 2021

based on heuristic

inferred from DOI database lookup

DNA ligase III as a candidate component of backup pathways of nonhomologous end joining

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

7 January 2021

based on heuristic

inferred from DOI database lookup

Neurodegeneration: nicked to death

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

7 January 2021

based on heuristic

inferred from DOI database lookup

Insights into the mechanisms of sister chromatid exchange formation

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

7 January 2021

based on heuristic

inferred from DOI database lookup

DNA damage levels and biochemical repair capacities associated with XRCC1 deficiency

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

7 January 2021

based on heuristic

inferred from DOI database lookup

XRCC1 and DNA polymerase beta interaction contributes to cellular alkylating-agent resistance and single-strand break repair

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

7 January 2021

based on heuristic

inferred from DOI database lookup

A Chinese hamster ovary cell mutant (EM-C11) with sensitivity to simple alkylating agents and a very high level of sister chromatid exchanges

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

7 January 2021

based on heuristic

inferred from DOI database lookup

The role of NBS1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint control

1 reference

https://api.crossref.org/works/10.1002%2FEM.20312

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1002/EM.20312

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/17603793

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/17603793

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