(Q51805894)

12 April 2018

title

Disopyramide is an effective inhibitor of mutant HERG K+ channels involved in variant 1 short QT syndrome. (English)

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12 April 2018

main subject

disopyramide

1 reference

ChEBI release 2020-05-28

Mark J McPate

1

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12 April 2018

Rona S Duncan

series ordinal

2

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12 April 2018

Harry J Witchel

series ordinal

3

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12 April 2018

Jules C Hancox

series ordinal

4

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12 April 2018

publication date

12 July 2006

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12 April 2018

Journal of Molecular and Cellular Cardiology

published in

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12 April 2018

volume

41

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12 April 2018

issue

3

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12 April 2018

page(s)

563-566

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12 April 2018

Idiopathic short QT interval: a new clinical syndrome?

cites work

2 references

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Short QT Syndrome: a familial cause of sudden death

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Sudden death associated with short-QT syndrome linked to mutations in HERG.

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Short QT syndrome and atrial fibrillation caused by mutation in KCNH2.

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Mutation in the KCNQ1 gene leading to the short QT-interval syndrome

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De novo KCNQ1 mutation responsible for atrial fibrillation and short QT syndrome in utero.

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A novel form of short QT syndrome (SQT3) is caused by a mutation in the KCNJ2 gene

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The N588K-HERG K+ channel mutation in the 'short QT syndrome': mechanism of gain-in-function determined at 37 degrees C.

7 January 2021

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Modulation of I(Kr) inactivation by mutation N588K in KCNH2: a link to arrhythmogenesis in short QT syndrome

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Congenital short QT syndrome and implantable cardioverter defibrillator treatment: inherent risk for inappropriate shock delivery

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Short QT syndrome: pharmacological treatment

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Further insights into the effect of quinidine in short QT syndrome caused by a mutation in HERG

7 January 2021

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Blockade of HERG potassium currents by fluvoxamine: incomplete attenuation by S6 mutations at F656 or Y652

7 January 2021

1 reference

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A comparison of currents carried by HERG, with and without coexpression of MiRP1, and the native rapid delayed rectifier current. Is MiRP1 the missing link?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.05.021

hERG potassium channels and cardiac arrhythmia

7 January 2021

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Variability in the measurement of hERG potassium channel inhibition: effects of temperature and stimulus pattern

7 January 2021

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Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels

7 January 2021

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Molecular biology of K(+) channels and their role in cardiac arrhythmias

7 January 2021

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Inhibition of HERG potassium channel current by the class 1a antiarrhythmic agent disopyramide

7 January 2021

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Serum drug concentrations and adverse effects in cardiac patients after administration of a new controlled-release disopyramide preparation

7 January 2021

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Early afterdepolarizationlike activity in patients with class IA induced long QT syndrome and torsades de pointes

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7 January 2021

Identifiers

DOI

1 reference

12 April 2018

1 reference

12 April 2018