(Q51818149)

13 April 2018

title

Reactivity profiling: covalent modification of single nucleophile peptides for skin sensitization risk assessment. (English)

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13 April 2018

author name string

Maja Aleksic

1

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13 April 2018

Emma Thain

2

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Delphine Roger

3

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Ouarda Saib

4

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13 April 2018

Michael Davies

5

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Jin Li

6

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Aynur Aptula

7

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Raniero Zazzeroni

8

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publication date

16 February 2009

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13 April 2018

published in

Toxicological Sciences

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volume

108

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issue

2

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page(s)

401-411

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13 April 2018

Investigating protein haptenation mechanisms of skin sensitisers using human serum albumin as a model protein

cites work

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFP030

Mass spectrometric identification of covalent adducts of the skin allergen 2,4-dinitro-1-chlorobenzene and model skin proteins.

21 January 2018

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Effect of glutathione on the covalent binding of the 13C-labeled skin sensitizer 5-chloro-2-methylisothiazol-3-one to human serum albumin: identification of adducts by nuclear magnetic resonance, matrix-assisted laser desorption/ionization mass spec

21 January 2018

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Final report on the safety assessment of benzaldehyde

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Non-enzymatic glutathione reactivity and in vitro toxicity: a non-animal approach to skin sensitization

21 January 2018

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Measurement of allergenic potency using the local lymph node assay

21 January 2018

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A skin-like cytochrome P450 cocktail activates prohaptens to contact allergenic metabolites

21 January 2018

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Cytosolic and nuclear protein targets of thiol-reactive electrophiles

21 January 2018

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Hapten-protein binding: from theory to practical application in the in vitro prediction of skin sensitization

21 January 2018

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Drug-protein adducts: an industry perspective on minimizing the potential for drug bioactivation in drug discovery and development

21 January 2018

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Development of a peptide reactivity assay for screening contact allergens

21 January 2018

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Quantification of chemical peptide reactivity for screening contact allergens: a classification tree model approach

21 January 2018

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A future approach to measuring relative skin sensitising potency: a proposal

21 January 2018

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Peptide-binding assessment using mass spectrometry as a new screening method for skin sensitization

21 January 2018

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STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDS.

21 January 2018

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Studies of the chemical selectivity of hapten, reactivity, and skin sensitization potency. 2. nmr studies of the covalent binding of the (13)c-labeled skin sensitizers 2-[13C]- and 3-[13C]hex-1-ene- and 3-[13C]hexane-1,3-sultones to human serum albu

21 January 2018

1 reference

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Utility and limitations of a peptide reactivity assay to predict fragrance allergens in vitro.

21 January 2018

1 reference

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An integrated approach to identifying chemically induced posttranslational modifications using comparative MALDI-MS and targeted HPLC-ESI-MS/MS.

21 January 2018

1 reference

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Structure-activity relationships for reactivity of carbonyl-containing compounds with glutathione

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1093/TOXSCI/KFP030

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13 April 2018

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13 April 2018