(Q51839923)

13 April 2018

title

Cholecystokinin levels in prohormone convertase 2 knock-out mouse brain regions reveal a complex phenotype of region-specific alterations. (English)

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13 April 2018

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Margery C Beinfeld

1

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13 April 2018

Alissa Blum

2

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13 April 2018

Daesety Vishnuvardhan

3

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13 April 2018

Sanya Fanous

4

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13 April 2018

James E Marchand

5

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13 April 2018

language of work or name

English

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publication date

20 September 2005

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13 April 2018

Journal of Biological Chemistry

published in

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13 April 2018

volume

280

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issue

46

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13 April 2018

page(s)

38410-38415

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13 April 2018

Biosynthesis and processing of pro CCK: recent progress and future challenges

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500055200

Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, Furin, and Kex2: distinct chromosomal localization and messenger RNA distribution in brain and pituitary compared to PC2.

21 January 2018

1 reference

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Identification and functional expression of a new member of the mammalian Kex2-like processing endoprotease family: its striking structural similarity to PACE4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500055200

cDNA structure of the mouse and rat subtilisin/kexin-like PC5: a candidate proprotein convertase expressed in endocrine and nonendocrine cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500055200

Immunohistochemical evidence for the involvement of protein convertases 5A and 2 in the processing of pro-neurotensin in rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500055200

Immunohistochemical distribution of the prohormone convertase PC5-A in rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500055200

Distribution and colocalization of cholecystokinin with the prohormone convertase enzymes PC1, PC2, and PC5 in rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500055200

Genetic inactivation of prohormone convertase (PC1) causes a reduction in cholecystokinin (CCK) levels in the hippocampus, amygdala, pons and medulla in mouse brain that correlates with the degree of colocalization of PC1 and CCK mRNA in these struc

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500055200

CCK mRNA expression, pro-CCK processing, and regulated secretion of immunoreactive CCK peptides by rat insulinoma (RIN 5F) and mouse pituitary tumor (AtT-20) cells in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500055200

Establishment of a cholecystokinin-producing rat medullary thyroid carcinoma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500055200

Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500055200

Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500055200

Increased synthesis but decreased processing of neuronal proCCK in prohormone convertase 2 and 7B2 knockout animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500055200

Neuronal cell lines expressing PC5, but not PC1 or PC2, process Pro-CCK into glycine-extended CCK 12 and 22.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500055200

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500055200

cDNA structure, tissue distribution, and chromosomal localization of rat PC7, a novel mammalian proprotein convertase closest to yeast kexin-like proteinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500055200

Neuroendocrine-specific expression of the human prohormone convertase 1 gene. Hormonal regulation of transcription through distinct cAMP response elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500055200

Cholecystokinin (CCK) release from rat brain slices in vitro is enhanced by agents which elevate intracellular cAMP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500055200

Selective roles for the PC2 processing enzyme in the regulation of peptide neurotransmitter levels in brain and peripheral neuroendocrine tissues of PC2 deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500055200

21 January 2018

Identifiers

DOI

10.1074/JBC.M500055200

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13 April 2018

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13 April 2018