(Q51890656)

English

Small molecule inhibitor of type I transforming growth factor-β receptor kinase ameliorates the inhibitory milieu in injured brain and promotes regeneration of nigrostriatal dopaminergic axons.

scientific article published on 22 December 2010

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

17 April 2018

http://europepmc.org/abstract/MED/21259325

Small molecule inhibitor of type I transforming growth factor-β receptor kinase ameliorates the inhibitory milieu in injured brain and promotes regeneration of nigrostriatal dopaminergic axons. (English)

1 reference

Europe PubMed Central

PubMed publication ID

17 April 2018

http://europepmc.org/abstract/MED/21259325

1 reference

based on heuristic

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author name string

Nozomu Yoshioka

1

1 reference

Europe PubMed Central

PubMed publication ID

17 April 2018

http://europepmc.org/abstract/MED/21259325

Junko Kimura-Kuroda

2

1 reference

Europe PubMed Central

PubMed publication ID

17 April 2018

http://europepmc.org/abstract/MED/21259325

Taro Saito

3

1 reference

Europe PubMed Central

PubMed publication ID

17 April 2018

http://europepmc.org/abstract/MED/21259325

Koki Kawamura

4

1 reference

Europe PubMed Central

PubMed publication ID

17 April 2018

http://europepmc.org/abstract/MED/21259325

Shin-ichi Hisanaga

5

1 reference

Europe PubMed Central

PubMed publication ID

17 April 2018

http://europepmc.org/abstract/MED/21259325

Hitoshi Kawano

6

1 reference

Europe PubMed Central

PubMed publication ID

17 April 2018

http://europepmc.org/abstract/MED/21259325

publication date

22 December 2010

1 reference

Europe PubMed Central

PubMed publication ID

17 April 2018

http://europepmc.org/abstract/MED/21259325

Journal of Neuroscience Research

1 reference

Europe PubMed Central

PubMed publication ID

17 April 2018

http://europepmc.org/abstract/MED/21259325

89

1 reference

Europe PubMed Central

PubMed publication ID

17 April 2018

http://europepmc.org/abstract/MED/21259325

3

1 reference

Europe PubMed Central

PubMed publication ID

17 April 2018

http://europepmc.org/abstract/MED/21259325

381-393

1 reference

Europe PubMed Central

PubMed publication ID

17 April 2018

http://europepmc.org/abstract/MED/21259325

Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response

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Effects of transforming growth factor-beta 1 on the extracellular matrix and cytoskeleton of cultured astrocytes.

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Transforming growth factor-beta 1-mediated neuroprotection against excitotoxic injury in vivo

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Chondroitinase ABC promotes functional recovery after spinal cord injury

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Pharmacological modification of the extracellular matrix to promote regeneration of the injured brain and spinal cord

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Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice

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Functional axonal regeneration through astrocytic scar genetically modified to digest chondroitin sulfate proteoglycans

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The neuroprotective role of inflammation in nervous system injuries.

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Decorin suppresses neurocan, brevican, phosphacan and NG2 expression and promotes axon growth across adult rat spinal cord injuries

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Reactive astrocytes protect tissue and preserve function after spinal cord injury

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The glial scar and central nervous system repair

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Differential response of arcuate proopiomelanocortin- and neuropeptide Y-containing neurons to the lesion produced by gold thioglucose administration.

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Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-beta signaling.

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Migration of dopaminergic neurons in the embryonic mesencephalon of mice

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Inhibition of collagen synthesis overrides the age-related failure of regeneration of nigrostriatal dopaminergic axons

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An in vitro model of the inhibition of axon growth in the lesion scar formed after central nervous system injury

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The effects of treatment with antibodies to transforming growth factor beta1 and beta2 following spinal cord damage in the adult rat.

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Suppression of fibrous scarring in spinal cord injury of rat promotes long-distance regeneration of corticospinal tract axons, rescue of primary motoneurons in somatosensory cortex and significant functional recovery

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21 January 2018

Expression of transforming growth factor-beta receptors in meningeal fibroblasts of the injured mouse brain.

1 reference

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21 January 2018

Inhibiting glycosaminoglycan chain polymerization decreases the inhibitory activity of astrocyte-derived chondroitin sulfate proteoglycans

1 reference

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21 January 2018

Expression of TGFbeta2 but not TGFbeta1 correlates with the deposition of scar tissue in the lesioned spinal cord.

1 reference

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21 January 2018

Regeneration of nigrostriatal dopaminergic axons by degradation of chondroitin sulfate is accompanied by elimination of the fibrotic scar and glia limitans in the lesion site.

1 reference

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Repair of adult rat corticospinal tract by transplants of olfactory ensheathing cells.

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Enhanced expression of transforming growth factor beta 1 in the rat brain after a localized cerebral injury

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21 January 2018

Effects of transforming growth factor beta 1 on scar production in the injured central nervous system of the rat.

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21 January 2018

Inhibition of glial scarring in the injured rat brain by a recombinant human monoclonal antibody to transforming growth factor-beta2.

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21 January 2018

Decorin attenuates gliotic scar formation in the rat cerebral hemisphere

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21 January 2018

Metallothionein I,II deficient mice do not exhibit significantly worse long-term behavioral outcomes following neonatal hypoxia-ischemia: MT-I,II deficient mice have inherent behavioral impairments.

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21 January 2018

Reduction in CNS scar formation without concomitant increase in axon regeneration following treatment of adult rat brain with a combination of antibodies to TGFbeta1 and beta2.

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https://api.crossref.org/works/10.1002%2FJNR.22552

21 January 2018

Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury.

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21 January 2018

Transforming growth factor beta 1 and fibronectin messenger RNA in rat brain: responses to injury and cell-type localization

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21 January 2018

Chondroitin sulphate proteoglycans: preventing plasticity or protecting the CNS?

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21 January 2018

The injury response of oligodendrocyte precursor cells is induced by platelets, macrophages and inflammation-associated cytokines

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21 January 2018

Smad3: a key player in pathogenetic mechanisms dependent on TGF-beta

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21 January 2018

Myelin-, reactive glia-, and scar-derived CNS axon growth inhibitors: expression, receptor signaling, and correlation with axon regeneration

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Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain

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Fibrinogen triggers astrocyte scar formation by promoting the availability of active TGF-beta after vascular damage

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Enhanced regenerative axon growth of multiple fibre populations in traumatic spinal cord injury following scar-suppressing treatment

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The astrocyte/meningeal cell interface--a barrier to successful nerve regeneration?

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Mechanisms of TGF-beta signaling from cell membrane to the nucleus

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Regeneration beyond the glial scar

1 reference

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Growth factor and cytokine regulation of chondroitin sulfate proteoglycans by astrocytes.

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Inhibition of collagen IV deposition promotes regeneration of injured CNS axons

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Basal membrane-depleted scar in lesioned CNS: characteristics and relationships with regenerating axons

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Regeneration of nigrostriatal dopaminergic axons after transplantation of olfactory ensheathing cells and fibroblasts prevents fibrotic scar formation at the lesion site

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A unique CD45 glycoform recognized by the serum mannan-binding protein in immature thymocytes

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Smad3 null mice display more rapid wound closure and reduced scar formation after a stab wound to the cerebral cortex.

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Rosiglitazone abrogates bleomycin-induced scleroderma and blocks profibrotic responses through peroxisome proliferator-activated receptor-gamma

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Glial inhibition of CNS axon regeneration

1 reference

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Suppression of fibrotic scar formation promotes axonal regeneration without disturbing blood-brain barrier repair and withdrawal of leukocytes after traumatic brain injury

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21 January 2018

Identifiers

10.1002/JNR.22552

1 reference

Europe PubMed Central

PubMed publication ID

17 April 2018

http://europepmc.org/abstract/MED/21259325

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

17 April 2018

http://europepmc.org/abstract/MED/21259325

ResearchGate publication ID

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