(Q51890704)

17 April 2018

title

Interpretation of the FGF8 morphogen gradient is regulated by endocytic trafficking. (English)

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17 April 2018

author

Michael Brand

5

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17 April 2018

author name string

Matthias Nowak

1

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17 April 2018

Anja Machate

2

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17 April 2018

Shuizi Rachel Yu

3

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17 April 2018

Mansi Gupta

4

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17 April 2018

publication date

23 January 2011

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17 April 2018

published in

Nature Cell Biology

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17 April 2018

volume

13

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17 April 2018

issue

2

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17 April 2018

page(s)

153-158

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17 April 2018

https://scigraph.springernature.com/pub.10.1038/ncb2155

exact match

0 references

cites work

Morphogens, their identification and regulation

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Positional information and the spatial pattern of cellular differentiation

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Regulative feedback in pattern formation: towards a general relativistic theory of positional information

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Tight transcriptional control of the ETS domain factors Erm and Pea3 by Fgf signaling during early zebrafish development.

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Roles for FGF8 in the induction, initiation, and maintenance of chick limb development

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Fgf8 and Fgf3 are required for zebrafish ear placode induction, maintenance and inner ear patterning

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Endocytosis controls spreading and effective signaling range of Fgf8 protein

21 January 2018

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Fgf8 morphogen gradient forms by a source-sink mechanism with freely diffusing molecules.

21 January 2018

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Interpretation of the wingless gradient requires signaling-induced self-inhibition.

21 January 2018

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Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanism

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Cellular signaling by fibroblast growth factor receptors

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Negative receptor signalling

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Ubiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosis

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EGF receptor ubiquitination is not necessary for its internalization

21 January 2018

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Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors

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Comparative genomic organization of the cbl genes

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Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations

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Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1

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Rab conversion as a mechanism of progression from early to late endosomes

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Different intracellular trafficking of FGF1 endocytosed by the four homologous FGF receptors

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Rab proteins as membrane organizers

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Kinase-regulated quantal assemblies and kiss-and-run recycling of caveolae

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Duplication of fgfr1 permits Fgf signaling to serve as a target for selection during domestication

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Common and distinct elements in cellular signaling via EGF and FGF receptors

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Regulating the regulator: negative regulation of Cbl ubiquitin ligases

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Src promotes destruction of c-Cbl: implications for oncogenic synergy between Src and growth factor receptors

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Dynamic interpretation of hedgehog signaling in the Drosophila wing disc

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Wnt11 functions in gastrulation by controlling cell cohesion through Rab5c and E-cadherin

21 January 2018

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Induction and differentiation of the zebrafish heart requires fibroblast growth factor 8 (fgf8/acerebellar).

21 January 2018

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12 December 2020

FGF-8 isoforms activate receptor splice forms that are expressed in mesenchymal regions of mouse development

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12 December 2020

Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesis

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12 December 2020

Morphogen gradient interpretation by a regulated trafficking step during ligand-receptor transduction

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12 December 2020

FGF signalling in the early specification of mesoderm in Xenopus

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12 December 2020

Identifiers

DOI

10.1038/NCB2155

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17 April 2018

1 reference

17 April 2018