(Q51913215)

17 April 2018

title

Understanding hERG inhibition with QSAR models based on a one-dimensional molecular representation. (English)

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17 April 2018

author name string

David J Diller

series ordinal

1

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17 April 2018

Doug W Hobbs

series ordinal

2

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17 April 2018

publication date

5 June 2007

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17 April 2018

Journal of Computer - Aided Molecular Design

published in

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17 April 2018

volume

21

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17 April 2018

issue

7

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17 April 2018

page(s)

379-393

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17 April 2018

Validation of a [3H]astemizole binding assay in HEK293 cells expressing HERG K+ channels

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Mechanism of action potential prolongation by RP 58866 and its active enantiomer, terikalant. Block of the rapidly activating delayed rectifier K+ current, IKr.

21 January 2018

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Block of the rapid component of the delayed rectifier potassium current by the prokinetic agent cisapride underlies drug-related lengthening of the QT interval

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10822-007-9122-2

Molecular determinants of dofetilide block of HERG K+ channels.

21 January 2018

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Mechanism of block and identification of the verapamil binding domain to HERG potassium channels

21 January 2018

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Short- and long-term effects of amiodarone on the two components of cardiac delayed rectifier K(+) current

21 January 2018

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HERG, a primary human ventricular target of the nonsedating antihistamine terfenadine

21 January 2018

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Safety of non-antiarrhythmic drugs that prolong the QT interval or induce torsade de pointes: an overview

21 January 2018

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12 December 2020

Inhibition of the human ether-a-go-go-related gene (HERG) potassium channel by cisapride: affinity for open and inactivated states.

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12 December 2020

The antipsychotic agent sertindole is a high affinity antagonist of the human cardiac potassium channel HERG.

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12 December 2020

One-dimensional molecular representations and similarity calculations: methodology and validation

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12 December 2020

Arrhythmogenic mechanisms of non-sedating antihistamines

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12 December 2020

A model for identifying HERG K+ channel blockers

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12 December 2020

The pharmacophore hypotheses of IKr potassium channel blockers: novel class III antiarrhythmic agents

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12 December 2020

Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site

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12 December 2020

Molecular basis for the lack of HERG K+ channel block-related cardiotoxicity by the H1 receptor blocker cetirizine compared with other second-generation antihistamines

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12 December 2020

Medicinal chemistry of hERG optimizations: Highlights and hang-ups

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12 December 2020

Troubleshooting problems with in vitro screening of drugs for QT interval prolongation using HERG K+ channels expressed in mammalian cell lines and Xenopus oocytes

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12 December 2020

Loratadine blockade of K(+) channels in human heart: comparison with terfenadine under physiological conditions

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12 December 2020

QT-interval prolongation by non-cardiac drugs: lessons to be learned from recent experience

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12 December 2020

Drug-induced long QT in isolated rabbit Purkinje fibers: importance of action potential duration, triangulation and early afterdepolarizations

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12 December 2020

Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods

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12 December 2020

Suppression of mammalian K+ channel family by ebastine.

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12 December 2020

Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature

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12 December 2020

Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers

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12 December 2020

New insights about HERG blockade obtained from protein modeling, potential energy mapping, and docking studies

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12 December 2020

Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents

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12 December 2020

Effect of verapamil enantiomers and metabolites on cardiac K+ channels expressed in Xenopus oocytes.

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12 December 2020

Rb+ flux through hERG channels affects the potency of channel blocking drugs: correlation with data obtained using a high-throughput Rb+ efflux assay

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12 December 2020

Class III antiarrhythmic activity in vivo by selective blockade of the slowly activating cardiac delayed rectifier potassium current IKs by (R)-2-(2,4-trifluoromethyl)-N-[2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)- 2, 3-dihydro-1H-benzo[e][1,4]diazepin

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12 December 2020

Molecular determinant of high-affinity dofetilide binding to HERG1 expressed in Xenopus oocytes: involvement of S6 sites.

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12 December 2020

A high-throughput HERG potassium channel function assay: an old assay with a new look

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12 December 2020

Common pharmacophores for uncharged human ether-a-go-go-related gene (hERG) blockers

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12 December 2020

A virtual screening method for prediction of the HERG potassium channel liability of compound libraries

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12 December 2020

Blockage of the HERG human cardiac K+ channel by the gastrointestinal prokinetic agent cisapride.

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12 December 2020

A two-state homology model of the hERG K+ channel: application to ligand binding

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12 December 2020

Electrophysiological characterization of the prokinetic agents cisapride and mosapride in vivo and in vitro: implications for proarrhythmic potential?

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12 December 2020

[3H]dofetilide binding to HERG transfected membranes: a potential high throughput preclinical screen.

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12 December 2020

A comparison of the receptor binding and HERG channel affinities for a series of antipsychotic drugs

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12 December 2020

An electrotopological-state index for atoms in molecules

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12 December 2020

The [3H]dofetilide binding assay is a predictive screening tool for hERG blockade and proarrhythmia: Comparison of intact cell and membrane preparations and effects of altering [K+]o

1 reference

12 December 2020

High affinity blockade of the HERG cardiac K(+) channel by the neuroleptic pimozide

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12 December 2020

Vesnarinone prolongs action potential duration without reverse frequency dependence in rabbit ventricular muscle by blocking the delayed rectifier K+ current

1 reference

12 December 2020

Three-dimensional quantitative structure-activity relationship for inhibition of human ether-a-go-go-related gene potassium channel

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12 December 2020

Sildenafil (Viagra) prolongs cardiac repolarization by blocking the rapid component of the delayed rectifier potassium current

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12 December 2020

4,5-Dihydro-3-(methanesulfonamidophenyl)-1-phenyl-1H-2,4-benzodiazepines: A Novel Class III Antiarrhythmic Agents

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12 December 2020

The role of the delayed rectifier component IKs in dog ventricular muscle and Purkinje fibre repolarization

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12 December 2020

The potential for QT prolongation and pro-arrhythmia by non-anti-arrhythmic drugs: clinical and regulatory implications. Report on a Policy Conference of the European Society of Cardiology.

1 reference

12 December 2020

Dofetilide block involves interactions with open and inactivated states of HERG channels

1 reference

12 December 2020

Protein trafficking abnormalities: a new mechanism in drug-induced long QT syndrome

1 reference

12 December 2020

Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists terfenadine and astemizole

1 reference

12 December 2020

Electrophysiological effects of risperidone in mammalian cardiac cells

1 reference

12 December 2020

Fast small molecule similarity searching with multiple alignment profiles of molecules represented in one-dimension

1 reference

12 December 2020

High affinity open channel block by dofetilide of HERG expressed in a human cell line.

1 reference

12 December 2020

The inhibitory effect of the antipsychotic drug haloperidol on HERG potassium channels expressed in Xenopus oocytes

1 reference

12 December 2020

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

1 reference

12 December 2020

Inhibitory effects of the class III antiarrhythmic drug amiodarone on cloned HERG potassium channels

1 reference

12 December 2020

Development and evaluation of high throughput functional assay methods for HERG potassium channel

1 reference

12 December 2020

Characterization of HERG potassium channel inhibition using CoMSiA 3D QSAR and homology modeling approaches

1 reference

12 December 2020

The discovery of novel chemotypes of p38 kinase inhibitors

1 reference

12 December 2020

Evaluation of the rubidium efflux assay for preclinical identification of HERG blockade.

1 reference

12 December 2020

Predictive in silico modeling for hERG channel blockers

1 reference

12 December 2020

Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels

1 reference

12 December 2020

Epinastine, a nonsedating histamine H1 receptor antagonist, has a negligible effect on HERG channel

1 reference

12 December 2020

Electrophysiological safety of sertindole in dogs with normal and remodeled hearts

1 reference

12 December 2020

Review of the predictive value of the Langendorff heart model (Screenit system) in assessing the proarrhythmic potential of drugs

1 reference

12 December 2020

A mechanism for the proarrhythmic effects of cisapride (Propulsid): high affinity blockade of the human cardiac potassium channel HERG.

1 reference

12 December 2020

Structural determinants for high-affinity block of hERG potassium channels.

1 reference

12 December 2020

10.1007/S10822-007-9122-2

Identifiers

DOI

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17 April 2018

DBLP publication ID

journals/jcamd/DillerH07

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DBLP Dataset 2021-01-02

28 January 2021

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17 April 2018