(Q51924536)

17 April 2018

title

Modeling of acetylcholinesterase inhibition by tacrine analogues using Bayesian-regularized Genetic Neural Networks and ensemble averaging. (English)

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17 April 2018

author

Julio Caballero

4

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17 April 2018

author name string

Michael Fernández

1

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17 April 2018

M Carmo Carreiras

2

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17 April 2018

José L Marco

3

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17 April 2018

publication date

1 December 2006

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17 April 2018

Journal of Enzyme Inhibition and Medicinal Chemistry

published in

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17 April 2018

volume

21

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17 April 2018

issue

6

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17 April 2018

page(s)

647-661

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17 April 2018

https://api.crossref.org/works/10.1080%2F14756360600862366

1 reference

Acetylcholinesterase inhibitors for potential use in Alzheimer's disease: molecular modeling, synthesis and kinetic evaluation of 11H-indeno-[1,2-b]-quinolin-10-ylamine derivatives.

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1 reference

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SAR of 9-amino-1,2,3,4-tetrahydroacridine-based acetylcholinesterase inhibitors: synthesis, enzyme inhibitory activity, QSAR, and structure-based CoMFA of tacrine analogues

21 January 2018

1 reference

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Synthesis and evaluation of tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease.

21 January 2018

1 reference

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New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease

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1 reference

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Synthesis, in vitro pharmacology, and molecular modeling of syn-huprines as acetylcholinesterase inhibitors.

21 January 2018

1 reference

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Synthesis and acetylcholinesterase/butyrylcholinesterase inhibition activity of 4-amino-2, 3-diaryl-5, 6, 7, 8-tetrahydrofuro(and thieno)[2, 3-b]-quinolines, and 4-amino-5, 6, 7, 8, 9-pentahydro-2, 3-diphenylcyclohepta[e]furo(and thieno)-[2, 3-b]pyr

21 January 2018

1 reference

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Synthesis, biological evaluation and molecular modelling of diversely functionalized heterocyclic derivatives as inhibitors of acetylcholinesterase/butyrylcholinesterase and modulators of Ca2+ channels and nicotinic receptors.

21 January 2018

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Neural networks: A new method for solving chemical problems or just a passing phase?

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Modeling of farnesyltransferase inhibition by some thiol and non-thiol peptidomimetic inhibitors using genetic neural networks and RDF approaches.

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Modeling of activity of cyclic urea HIV-1 protease inhibitors using regularized-artificial neural networks

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Development of linear, ensemble, and nonlinear models for the prediction and interpretation of the biological activity of a set of PDGFR inhibitors.

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New molecular descriptors for 2D and 3D structures. Theory

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Linear and nonlinear modeling of antifungal activity of some heterocyclic ring derivatives using multiple linear regression and Bayesian-regularized neural networks.

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Evolutionary optimization in quantitative structure-activity relationship: an application of genetic neural networks

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A Practical Bayesian Framework for Backpropagation Networks

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Robust QSAR models using Bayesian regularized neural networks.

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On the use of neural network ensembles in QSAR and QSPR.

21 January 2018

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21 January 2018

Neural network ensembles

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Modeling of cyclin-dependent kinase inhibition by 1H-pyrazolo[3,4-d]pyrimidine derivatives using artificial neural network ensembles.

21 January 2018

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Atomic Structure of Acetylcholinesterase from Torpedo californica : A Prototypic Acetylcholine-Binding Protein

21 January 2018

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Interpreting computational neural network quantitative structure-activity relationship models: a detailed interpretation of the weights and biases.

21 January 2018

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On the Physical Interpretation of QSAR Models

21 January 2018

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Highly potent, selective, and low cost bis-tetrahydroaminacrine inhibitors of acetylcholinesterase. Steps toward novel drugs for treating Alzheimer's disease

21 January 2018

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A comparative QSAR analysis of acetylcholinesterase inhibitors currently studied for the treatment of Alzheimer's disease

21 January 2018

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Broad-based quantitative structure-activity relationship modeling of potency and selectivity of farnesyltransferase inhibitors using a Bayesian regularized neural network

21 January 2018

1 reference

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Self-Organized Formation of Topologically Correct Feature Maps

21 January 2018

1 reference

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21 January 2018

Bayesian Interpolation

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Modulation of Binding Strength in Several Classes of Active Site Inhibitors of Acetylcholinesterase Studied by Comparative Binding Energy Analysis

21 January 2018

1 reference

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Structure/Response Correlations and Similarity/Diversity Analysis by GETAWAY Descriptors. 1. Theory of the Novel 3D Molecular Descriptors

21 January 2018

1 reference

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10.1080/14756360600862366

21 January 2018

Identifiers

DOI

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17 April 2018

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17 April 2018