(Q51963492)

19 April 2018

title

Liver-specific expression of p53-negative regulator mdm2 leads to growth retardation and fragile liver in zebrafish. (English)

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19 April 2018

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Li-Je Chen

1

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19 April 2018

Chia-Chun Hsu

2

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19 April 2018

Jiann-Ruey Hong

3

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19 April 2018

Luen-Kuang Jou

4

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19 April 2018

Hung-Chia Tseng

5

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19 April 2018

Jen-Leih Wu

6

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19 April 2018

Yih-Cherng Liou

7

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19 April 2018

Guor Mour Her

8

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19 April 2018

publication date

1 April 2008

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19 April 2018

published in

Developmental Dynamics

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19 April 2018

volume

237

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19 April 2018

issue

4

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19 April 2018

page(s)

1070-1081

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19 April 2018

Dynamics in the p53-Mdm2 ubiquitination pathway

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tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors

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A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans

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MDM2 SNP309 Accelerates Tumor Formation in a Gender-Specific and Hormone-Dependent Manner

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Loss of function of def selectively up-regulates Delta113p53 expression to arrest expansion growth of digestive organs in zebrafish.

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The p53 paddy wagon: COP1, Pirh2 and MDM2 are found resisting apoptosis and growth arrest

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Overexpression of mouse Mdm2 induces developmental phenotypes in Drosophila.

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The p53 tumor suppressor participates in multiple cell cycle checkpoints

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Mdm2 is required for inhibition of Cdk2 activity by p21, thereby contributing to p53-dependent cell cycle arrest

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Adenomatous polyposis coli-deficient zebrafish are susceptible to digestive tract neoplasia

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7 January 2021

p53 modulation of the DNA damage response

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7 January 2021

In vivo studies of liver-type fatty acid binding protein (L-FABP) gene expression in liver of transgenic zebrafish (Danio rerio).

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435-bp liver regulatory sequence in the liver fatty acid binding protein (L-FABP) gene is sufficient to modulate liver regional expression in transgenic zebrafish

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7 January 2021

Imbalance in liver homeostasis leading to hyperplasia by overexpressing either one of the Bcl-2-related genes, zfBLP1 and zfMcl-1a

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Zebrafish relatively relaxed mutants have a ryanodine receptor defect, show slow swimming and provide a model of multi-minicore disease.

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7 January 2021

Zebrafish pronephros: a model for understanding cystic kidney disease.

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7 January 2021

MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation

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7 January 2021

MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation

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7 January 2021

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7 January 2021

Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis

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7 January 2021

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7 January 2021

Lessons from p53 in non-mammalian models.

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7 January 2021

Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53.

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7 January 2021

Conservation of structural domains and biochemical activities of the MDM2 protein from Xenopus laevis

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7 January 2021

Twenty years of p53 research: structural and functional aspects of the p53 protein

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7 January 2021

p53-dependent cell death signaling in neurons

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7 January 2021

Excess HDM2 impacts cell cycle and apoptosis and has a selective effect on p53-dependent transcription.

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7 January 2021

Mdm2: p53's lifesaver?

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7 January 2021

The Mdm2 gene of zebrafish (Danio rerio): preferential expression during development of neural and muscular tissues, and absence of tumor formation after overexpression of its cDNA during early embryogenesis.

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7 January 2021

Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

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7 January 2021

Genetic instability, oncogenes, and the p53 pathway

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7 January 2021

p53 activity is essential for normal development in Xenopus.

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7 January 2021

Regulating the p53 system through ubiquitination

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7 January 2021

MDM2 is a negative regulator of p21WAF1/CIP1, independent of p53.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.21477

7 January 2021

Identifiers

DOI

10.1002/DVDY.21477

1 reference

19 April 2018

1 reference

19 April 2018