(Q5198270)

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24385&geneProductId=UniProtKB:P24385

transcription corepressor activity

transcription factor binding

histone deacetylase binding

IPI

1 reference

1 January 2018

Identification of an INSM1-binding site in the insulin promoter: negative regulation of the insulin gene transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

cyclin-dependent protein serine/threonine kinase regulator activity

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24385&geneProductId=UniProtKB:P24385

29 references

1 January 2018

NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

Cyclin-binding motifs are essential for the function of p21CIP1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

Cyclin D1 interacts and collaborates with Ral GTPases enhancing cell detachment and motility

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

Self-assembling protein microarrays

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

New functional activities for the p21 family of CDK inhibitors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

A code for RanGDP binding in ankyrin repeats defines a nuclear import pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

Crystal structure of human CDK4 in complex with a D-type cyclin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

C/EBP{delta} targets cyclin D1 for proteasome-mediated degradation via induction of CDC27/APC3 expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

Pooled-matrix protein interaction screens using Barcode Fusion Genetics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

Widespread macromolecular interaction perturbations in human genetic disorders

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

Functional consequences of cyclin D1/BRCA1 interaction in breast cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

Toward an understanding of the protein interaction network of the human liver

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

Isolation and characterization of cytoplasmic cyclin D1 mutants

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

Functional characterization of human PFTK1 as a cyclin-dependent kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

Cyclin D1b variant influences prostate cancer growth through aberrant androgen receptor regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

Next-generation sequencing to generate interactome datasets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 reference

1 January 2018

F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

proline-rich region binding

IPI

1 reference

1 January 2018

Zinc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrest

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

Zinc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrest

protein kinase binding

3 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24385&geneProductId=UniProtKB:P24385

16 July 2018

Identification of G1 kinase activity for cdk6, a novel cyclin D partner

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24385&geneProductId=UniProtKB:P24385

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24385&geneProductId=UniProtKB:P24385

cyclin-dependent protein serine/threonine kinase activity

1 reference

10 September 2018

Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24385&geneProductId=UniProtKB:P24385

protein-containing complex binding

EXP

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

Zinc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrest

protein kinase binding

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

Identification of G1 kinase activity for cdk6, a novel cyclin D partner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

cyclin-dependent protein kinase holoenzyme complex

3 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24385&geneProductId=UniProtKB:P24385

16 July 2018

Identification of G1 kinase activity for cdk6, a novel cyclin D partner

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24385&geneProductId=UniProtKB:P24385

16 July 2018

CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24385&geneProductId=UniProtKB:P24385

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

bicellular tight junction

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

transcription repressor complex

intracellular anatomical structure

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

2 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

4 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24385&geneProductId=UniProtKB:P24385

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24385&geneProductId=UniProtKB:P24385

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24385&geneProductId=UniProtKB:P24385

16 July 2018

Expression of frizzled-related protein and Wnt-signalling molecules in invasive human breast tumours

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24385&geneProductId=UniProtKB:P24385

cyclin-dependent protein kinase holoenzyme complex

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

Identification of G1 kinase activity for cdk6, a novel cyclin D partner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

5 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

Expression of frizzled-related protein and Wnt-signalling molecules in invasive human breast tumours

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

3 references

cellular response to organic substance

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

mammary gland epithelial cell proliferation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

positive regulation of mammary gland epithelial cell proliferation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

response to estradiol

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

positive regulation of protein phosphorylation

1 reference

1 January 2018

Identification of G1 kinase activity for cdk6, a novel cyclin D partner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

Leydig cell differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

regulation of transcription, DNA-templated

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24385&geneProductId=UniProtKB:P24385

response to organic cyclic compound

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

response to steroid hormone

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

response to corticosterone

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

negative regulation of Wnt signaling pathway

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24385&geneProductId=UniProtKB:P24385

response to magnesium ion

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

response to glucocorticoid

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

re-entry into mitotic cell cycle

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

negative regulation of transcription by RNA polymerase II

Wnt signaling pathway

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

mammary gland alveolus development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

response to organic substance

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

transcription, DNA-templated

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24385&geneProductId=UniProtKB:P24385

response to vitamin E

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

regulation of cell cycle

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

response to calcium ion

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

endoplasmic reticulum unfolded protein response

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

protein phosphorylation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

regulation of G1/S transition of mitotic cell cycle

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

mitotic G1 DNA damage checkpoint signaling

1 reference

1 January 2018

F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

animal organ regeneration

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

response to organonitrogen compound

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

positive regulation of cell population proliferation

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24385&geneProductId=UniProtKB:P24385

positive regulation of cyclin-dependent protein serine/threonine kinase activity

1 reference

1 January 2018

Identification of G1 kinase activity for cdk6, a novel cyclin D partner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

canonical Wnt signaling pathway

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24385&geneProductId=UniProtKB:P24385

1 reference

1 January 2018

UVA-induced cell cycle progression is mediated by a disintegrin and metalloprotease/epidermal growth factor receptor/AKT/Cyclin D1 pathways in keratinocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

positive regulation of G2/M transition of mitotic cell cycle

1 reference

1 January 2018

Zinc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrest

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 reference

1 January 2018

leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

negative regulation of epithelial cell differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

fat cell differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

positive regulation of cell cycle

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24385&geneProductId=UniProtKB:P24385

transcription initiation from RNA polymerase II promoter

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

G1/S transition of mitotic cell cycle

3 references

1 January 2018

UVA-induced cell cycle progression is mediated by a disintegrin and metalloprotease/epidermal growth factor receptor/AKT/Cyclin D1 pathways in keratinocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

cytokine-mediated signaling pathway

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

negative regulation of transcription by RNA polymerase II

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 January 2018

Identification of an INSM1-binding site in the insulin promoter: negative regulation of the insulin gene transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

positive regulation of epithelial cell proliferation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

regulation of cyclin-dependent protein serine/threonine kinase activity

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

regulation of mitotic nuclear division

IBA

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

positive regulation of G1/S transition of mitotic cell cycle

IBA

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24385

physically interacts with

IBA

1 reference

Open Targets Platform

retrieved

14 August 2023

https://platform.opentargets.org/drug/CHEMBL189963

Gene Atlas image

PBB GE CCND1 208712 at fs.png
732 × 530; 10 KB

0 references

exact match

http://purl.uniprot.org/uniprot/P24385

1 reference

Cyclin, C-terminal domain

Identifiers.org

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P24385

Cyclin-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P24385

Cyclin, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P24385

Identifiers

MeSH descriptor ID

D019938

subject named as

Cyclin D1

0 references

MeSH tree code

D12.644.360.262.150.100

0 references

D12.776.167.218.150.100

0 references

D12.776.476.262.150.100

0 references

D12.776.624.664.700.100

0 references

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference