(Q52115010)

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The non-immunosuppressive immunophilin ligand GPI-1046 potently stimulates regenerating axon growth from adult mouse dorsal root ganglia cultured in Matrigel.

scientific article published in January 2002

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scholarly article

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Europe PubMed Central

PubMed publication ID

22 April 2018

http://europepmc.org/abstract/MED/12220563

The non-immunosuppressive immunophilin ligand GPI-1046 potently stimulates regenerating axon growth from adult mouse dorsal root ganglia cultured in Matrigel. (English)

1 reference

Europe PubMed Central

PubMed publication ID

22 April 2018

http://europepmc.org/abstract/MED/12220563

Phillip R Gordon-Weeks

7

1 reference

Europe PubMed Central

PubMed publication ID

22 April 2018

http://europepmc.org/abstract/MED/12220563

author name string

Khan Z

1

1 reference

Europe PubMed Central

PubMed publication ID

22 April 2018

http://europepmc.org/abstract/MED/12220563

Ferrari G

2

1 reference

Europe PubMed Central

PubMed publication ID

22 April 2018

http://europepmc.org/abstract/MED/12220563

Kasper M

3

1 reference

Europe PubMed Central

PubMed publication ID

22 April 2018

http://europepmc.org/abstract/MED/12220563

Tonge DA

4

1 reference

Europe PubMed Central

PubMed publication ID

22 April 2018

http://europepmc.org/abstract/MED/12220563

Steiner JP

5

1 reference

Europe PubMed Central

PubMed publication ID

22 April 2018

http://europepmc.org/abstract/MED/12220563

Hamilton GS

6

1 reference

Europe PubMed Central

PubMed publication ID

22 April 2018

http://europepmc.org/abstract/MED/12220563

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publication date

1 January 2002

1 reference

Europe PubMed Central

PubMed publication ID

22 April 2018

http://europepmc.org/abstract/MED/12220563

1 reference

Europe PubMed Central

PubMed publication ID

22 April 2018

http://europepmc.org/abstract/MED/12220563

114

1 reference

Europe PubMed Central

PubMed publication ID

22 April 2018

http://europepmc.org/abstract/MED/12220563

3

1 reference

Europe PubMed Central

PubMed publication ID

22 April 2018

http://europepmc.org/abstract/MED/12220563

601-609

1 reference

Europe PubMed Central

PubMed publication ID

22 April 2018

http://europepmc.org/abstract/MED/12220563

Monoclonal antibodies show that neurofibrillary tangles and neurofilaments share antigenic determinants

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Immunophilin ligands and GDNF enhance neurite branching or elongation from developing dopamine neurons in culture

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Axonal outgrowth and neuronal apoptosis in cultured adult mouse dorsal root ganglion preparations: effects of neurotrophins, of inhibition of neurotrophin actions and of prior axotomy

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A phosphorylation epitope on MAP 1B that is transiently expressed in growing axons in the developing rat nervous system.

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Neuroimmunophilin ligands exert neuroregeneration and neuroprotection in midbrain dopaminergic neurons

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Analysis of the neurotrophic effects of GPI-1046 on neuron survival and regeneration in culture and in vivo

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Primary sensory neurones: Neurofilament, neuropeptides and conduction velocity

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Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

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Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia

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Neuronal regeneration enhances the expression of the immunophilin FKBP-12

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Tacrolimus (FK506) increases neuronal expression of GAP-43 and improves functional recovery after spinal cord injury in rats

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Complementary DNA encoding the human T-cell FK506-binding protein, a peptidylprolyl cis-trans isomerase distinct from cyclophilin

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Cellular functions of immunophilins

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IB4-binding DRG neurons switch from NGF to GDNF dependence in early postnatal life.

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Rapamycin, but not FK506 and GPI-1046, increases neurite outgrowth in PC12 cells by inhibiting cell cycle progression

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Immunophilins and nervous system

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High brain densities of the immunophilin FKBP colocalized with calcineurin

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Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models

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Expression of a developmentally regulated, phosphorylated isoform of microtubule-associated protein 1B in sprouting and regenerating axons in vitro.

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Evidence that biological activity of NGF is mediated through a novel subclass of high affinity receptors

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Neurotrophin receptor mRNA expression defines distinct populations of neurons in rat dorsal root ganglia

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Identifiers

10.1016/S0306-4522(02)00314-7

1 reference

Europe PubMed Central

PubMed publication ID

22 April 2018

http://europepmc.org/abstract/MED/12220563

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

22 April 2018

http://europepmc.org/abstract/MED/12220563

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