(Q52124627)

22 April 2018

title

Vav cooperates with CD28 to induce NF-kappaB activation via a pathway involving Rac-1 and mitogen-activated kinase kinase 1. (English)

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22 April 2018

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2

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22 April 2018

Loretta Tuosto

9

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22 April 2018

author name string

Barbara Marinari

1

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22 April 2018

Antonella Viola

3

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22 April 2018

Frederique Michel

4

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22 April 2018

Giorgio Mangino

5

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22 April 2018

Oreste Acuto

6

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22 April 2018

Massimo Levrero

7

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22 April 2018

Enza Piccolella

8

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22 April 2018

language of work or name

English

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publication date

1 February 2002

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22 April 2018

European Journal of Immunology

published in

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22 April 2018

volume

32

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22 April 2018

page(s)

447-456

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22 April 2018

issue

2

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22 April 2018

Co-stimulation in T cell responses.

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CD28 affects the earliest signaling events generated by TCR engagement.

21 January 2018

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CD28 mediates transcriptional upregulation of the interleukin-2 (IL-2) promoter through a composite element containing the CD28RE and NF-IL-2B AP-1 sites

21 January 2018

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JNK is involved in signal integration during costimulation of T lymphocytes.

21 January 2018

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The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

21 January 2018

1 reference

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Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation

21 January 2018

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Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation

21 January 2018

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The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases

21 January 2018

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Mixed-lineage kinase 3 delivers CD3/CD28-derived signals into the IkappaB kinase complex

21 January 2018

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Mitogen-activated kinase kinase kinase 1 regulates T cell receptor- and CD28-mediated signaling events which lead to NF-kappaB activation.

21 January 2018

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Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav.

21 January 2018

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Dbl and Vav mediate transformation via mitogen-activated protein kinase pathways that are distinct from those activated by oncogenic Ras

21 January 2018

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p95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells

21 January 2018

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Fyn and ZAP-70 are required for Vav phosphorylation in T cells stimulated by antigen-presenting cells

21 January 2018

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Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

21 January 2018

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Lck regulates Vav activation of members of the Rho family of GTPases

21 January 2018

1 reference

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Lymphocyte signalling: a coordinating role for Vav?

21 January 2018

1 reference

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CD28 utilizes Vav-1 to enhance TCR-proximal signaling and NF-AT activation.

21 January 2018

1 reference

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The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-kappaB pathways

21 January 2018

1 reference

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Vav synergizes with protein kinase C theta to mediate IL-4 gene expression in response to CD28 costimulation in T cells

21 January 2018

1 reference

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Tyrosine-phosphorylated Vav1 as a point of integration for T-cell receptor- and CD28-mediated activation of JNK, p38, and interleukin-2 transcription

21 January 2018

1 reference

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Vav-Rac1-mediated activation of the c-Jun N-terminal kinase/c-Jun/AP-1 pathway plays a major role in stimulation of the distal NFAT site in the interleukin-2 gene promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200202%2932%3A2%3C447%3A%3AAID-IMMU447%3E3.0.CO%3B2-5

NMR structure and mutagenesis of the N-terminal Dbl homology domain of the nucleotide exchange factor Trio

21 January 2018

1 reference

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Protein kinase C-theta participates in NF-kappaB activation induced by CD3-CD28 costimulation through selective activation of IkappaB kinase beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200202%2932%3A2%3C447%3A%3AAID-IMMU447%3E3.0.CO%3B2-5

The physical association of protein kinase C theta with a lipid raft-associated inhibitor of kappa B factor kinase (IKK) complex plays a role in the activation of the NF-kappa B cascade by TCR and CD28.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200202%2932%3A2%3C447%3A%3AAID-IMMU447%3E3.0.CO%3B2-5

Tumor necrosis factor (TNF) receptor 1 signaling downstream of TNF receptor-associated factor 2. Nuclear factor kappaB (NFkappaB)-inducing kinase requirement for activation of activating protein 1 and NFkappaB but not of c-Jun N-terminal kinase/stre

21 January 2018

1 reference

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Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase

21 January 2018

1 reference

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A novel functional interaction between Vav and PKCtheta is required for TCR-induced T cell activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200202%2932%3A2%3C447%3A%3AAID-IMMU447%3E3.0.CO%3B2-5

Ligation of either CD2 or CD28 rescues CD4+ T cells from HIV-gp120-induced apoptosis

21 January 2018

1 reference

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PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200202%2932%3A2%3C447%3A%3AAID-IMMU447%3E3.0.CO%3B2-5

T lymphocyte costimulation mediated by reorganization of membrane microdomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200202%2932%3A2%3C447%3A%3AAID-IMMU447%3E3.0.CO%3B2-5

Synergistic activation of NF-kappa B by functional cooperation between vav and PKCtheta in T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200202%2932%3A2%3C447%3A%3AAID-IMMU447%3E3.0.CO%3B2-5

Multiple signalling pathways lead to the activation of the nuclear factor kappaB by the Rho family of GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200202%2932%3A2%3C447%3A%3AAID-IMMU447%3E3.0.CO%3B2-5

Networking Rho family GTPases in lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1521-4141%28200202%2932%3A2%3C447%3A%3AAID-IMMU447%3E3.0.CO%3B2-5

10.1002/1521-4141(200202)32:2<447::AID-IMMU447>3.0.CO;2-5

21 January 2018

Identifiers

DOI

1 reference

22 April 2018

PubMed ID

11813163

1 reference

22 April 2018