(Q52137539)

22 April 2018

title

Defining the specific physiological requirements for c-Myc in T cell development (English)

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22 April 2018

author

Adrian Hayday

4

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22 April 2018

author name string

Douglas NC

1

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22 April 2018

Jacobs H

2

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22 April 2018

Bothwell AL

3

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22 April 2018

language of work or name

English

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publication date

1 April 2001

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22 April 2018

published in

Nature Immunology

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22 April 2018

volume

2

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22 April 2018

issue

4

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22 April 2018

page(s)

307-315

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22 April 2018

Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc

cites work

1 reference

The role of c-myc in cell growth

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Function of the c-Myc oncogenic transcription factor.

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A genetic screen to identify genes that rescue the slow growth phenotype of c-myc null fibroblasts

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Expression and activity of L-Myc in normal mouse development

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Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene

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Differential expression of myc family genes during murine development

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Transcriptional down-regulation of N-myc expression during B-cell development

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Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation

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c-Myc enhances protein synthesis and cell size during B lymphocyte development

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Consequences of widespread deregulation of the c-myc gene in transgenic mice: multiple neoplasms and normal development

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Reversible tumorigenesis by MYC in hematopoietic lineages

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Productive T-cell receptor beta-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo

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Structure and function of the pre-T cell receptor

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FADD/MORT1 regulates the pre-TCR checkpoint and can function as a tumour suppressor

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c-Myb regulates the proliferation of immature thymocytes following beta-selection

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Redundant Regulation of T Cell Differentiation and TCRα Gene Expression by the Transcription Factors LEF-1 and TCF-1

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Disruption of epithelial gamma delta T cell repertoires by mutation of the Syk tyrosine kinase

21 January 2018

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RAG-1-deficient mice have no mature B and T lymphocytes

21 January 2018

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Extrathymic differentiation of intraepithelial lymphocytes: generation of a separate and unequal T-cell repertoire?

21 January 2018

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Peripheral engraftment of fetal intestine into athymic mice sponsors T cell development: direct evidence for thymopoietic function of murine small intestine

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Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages

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Rearrangement and diversity of T cell receptor beta chain genes in thymocytes: a critical role for the beta chain in development

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T cell receptor-negative thymocytes from SCID mice can be induced to enter the CD4/CD8 differentiation pathway

21 January 2018

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A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells

21 January 2018

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Developmental potential and dynamic behavior of hematopoietic stem cells

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Myc activates telomerase

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Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

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Analysis of C-MYC function in normal cells via conditional gene-targeted mutation

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Drosophila myc regulates cellular growth during development.

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Crucial function of the pre-T-cell receptor (TCR) in TCR beta selection, TCR beta allelic exclusion and alpha beta versus gamma delta lineage commitment

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Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression

21 January 2018

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Interleukin-7 regulates c-myc expression in murine T cells and thymocytes: a role for tyrosine kinase(s) and calcium mobilization

21 January 2018

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Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

21 January 2018

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Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice

21 January 2018

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Interleukin 7 receptor-deficient mice lack gammadelta T cells

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RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development

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Alpha beta and gamma delta T cells can share a late common precursor

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The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

21 January 2018

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Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells

21 January 2018

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Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop

21 January 2018

1 reference

7 January 2021

A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice

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7 January 2021

Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor

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7 January 2021

A new look at Syk in alpha beta and gamma delta T cell development using chimeric mice with a low competitive hematopoietic environment

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7 January 2021

T cell receptor beta chain gene rearrangement and selection during thymocyte development in adult mice

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7 January 2021

The human myc gene family

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7 January 2021

NF-kappa B activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development

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7 January 2021

Interleukin-7 induces N-myc and c-myc expression in normal precursor B lymphocytes

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7 January 2021

33 Polymerase chain reaction-based mRNA quantification using an internal standard: Analysis of oncogene expression

1 reference

7 January 2021

Identifiers

DOI

10.1038/86308

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22 April 2018

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22 April 2018