(Q52177288)

26 April 2018

title

Nerve growth factor induces survival and differentiation through two distinct signaling cascades in PC12 cells. (English)

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26 April 2018

author name string

Klesse LJ

1

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26 April 2018

Meyers KA

2

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26 April 2018

Marshall CJ

3

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26 April 2018

Parada LF

4

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26 April 2018

language of work or name

English

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publication date

1 March 1999

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26 April 2018

published in

Oncogene

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26 April 2018

volume

18

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26 April 2018

page(s)

2055-2068

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26 April 2018

issue

12

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26 April 2018

https://scigraph.springernature.com/pub.10.1038/sj.onc.1202524

exact match

0 references

cites work

Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Involvement of ras p21 in neurotrophin-induced response of sensory, but not sympathetic neurons

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Akt is a direct target of the phosphatidylinositol 3-kinase. Activation by growth factors, v-src and v-Ha-ras, in Sf9 and mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Shc Binding to Nerve Growth Factor Receptor Is Mediated by the Phosphotyrosine Interaction Domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Regulation of neuronal survival by the serine-threonine protein kinase Akt

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Characterization of apoptosis in cultured rat sympathetic neurons after nerve growth factor withdrawal

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Nerve growth factor prevents the death and stimulates the neuronal differentiation of clonal PC12 pheochromocytoma cells in serum-free medium

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Inhibition of growth factor-induced differentiation of PC12 cells by microinjection of antibody to ras p21

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Mutational activation of c-raf-1 and definition of the minimal transforming sequence

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Akt signaling: linking membrane events to life and death decisions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Nerve growth factor mediates signal transduction through trk homodimer receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

The trk Proto-Oncogene Product: a Signal Transducing Receptor for Nerve Growth Factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Signal transduction by the neurotrophin receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Regulators of cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Signal transduction by nerve growth factor and fibroblast growth factor in PC12 cells requires a sequence of src and ras actions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Ras-dependent growth factor regulation of MEK kinase in PC12 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Bcl-2 gene family in the nervous system

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Active p21Ras is sufficient for rescue of NGF-dependent rat sympathetic neurons

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Sarcoma viruses carrying ras oncogenes induce differentiation-associated properties in a neuronal cell line

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLC gamma.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Suc1-associated neurotrophic factor target (SNT) protein is a major FGF-stimulated tyrosine phosphorylated 90-kDa protein which binds to the SH2 domain of GRB2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

SNT, a differentiation-specific target of neurotrophic factor-induced tyrosine kinase activity in neurons and PC12 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Activation of phosphatidylinositol 3-kinase by epidermal growth factor, basic fibroblast growth factor, and nerve growth factor in PC12 pheochromocytoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Errors of homeostasis and deregulated apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Evidence for a Ras-dependent extracellular signal-regulated protein kinase (ERK) cascade

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Phosphatidylinositol-3-OH kinase as a direct target of Ras

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Multiple agents rescue PC12 cells from serum-free cell death by translation- and transcription-independent mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Intracellular signaling pathways activated by neurotrophic factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Dorsal root ganglion neurons require functional neurotrophin receptors for survival during development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Mechanism of activation of a human oncogene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Nerve growth factor-induced process formation by cultured rat pheochromocytoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Loss of neurofibromin results in neurotrophin-independent survival of embryonic sensory and sympathetic neurons

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Nutritional support of brain-injured patients. Brain Trauma Foundation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

The cytoplasmic raf oncogene induces a neuronal phenotype in PC12 cells: a potential role for cellular raf kinases in neuronal growth factor signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Prevention of PC12 cell death by N-acetylcysteine requires activation of the Ras pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

BH3 domain of BAD is required for heterodimerization with BCL-XL and pro-apoptotic activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202524

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1202524

1 reference

26 April 2018

PubMed ID

10321730

1 reference

26 April 2018