(Q52220311)

27 April 2018

title

Pharmacokinetic and pharmacodynamic evaluation for tissue-selective inhibition of cholesterol synthesis by pravastatin. (English)

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Hatanaka T

1

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Honda S

2

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Sasaki S

3

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Katayama K

4

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Koizumi T

5

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publication date

1 June 1998

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Journal of Pharmacokinetics and Pharmacodynamics

published in

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volume

26

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issue

3

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page(s)

329-347

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A review of clinical trials comparing HMG-CoA reductase inhibitors

cites work

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12 December 2020

Na(+)-independent multispecific anion transporter mediates active transport of pravastatin into rat liver.

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12 December 2020

Disposition of pravastatin sodium, a tissue-selective HMG-CoA reductase inhibitor, in healthy subjects

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12 December 2020

Hepatoselective carrier-mediated sodium-independent uptake of pravastatin and pravastatin-lactone

1 reference

12 December 2020

ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinium

1 reference

12 December 2020

Tissue-selective inhibition of cholesterol synthesis in vivo by pravastatin sodium, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor

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12 December 2020

Disposition and metabolism of pravastatin sodium in rats, dogs and monkeys

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12 December 2020

Hepatic and nonhepatic sterol synthesis and tissue distribution following administration of a liver selective HMG-CoA reductase inhibitor, CI-981: Comparison with selected HMG-CoA reductase inhibitors

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12 December 2020

Targeted drug delivery--some pharmacokinetic considerations

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12 December 2020

Biotransformation of pravastatin sodium in humans

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12 December 2020

Transcellular transport of benzoic acid across Caco-2 cells by a pH-dependent and carrier-mediated transport mechanism

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12 December 2020

The routine fitting of kinetic data to models: a mathematical formalism for digital computers

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12 December 2020

Physiological pharmacokinetics of ethoxybenzamide based on biochemical data obtained in vitro as well as on physiological data

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12 December 2020

Different effects of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors on sterol synthesis in various human cell types

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12 December 2020

Tissue selectivity of pravastatin sodium, lovastatin and simvastatin. The relationship between inhibition of de novo sterol synthesis and active drug concentrations in the liver, spleen and testis in rat

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12 December 2020

Carrier-mediated uptake of pravastatin by rat hepatocytes in primary culture

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12 December 2020

3-Hydroxy-3-methylglutaryl-coenzyme A reductase is present in peroxisomes in normal rat liver cells

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12 December 2020

3-Hydroxy-3-methylglutaryl--coenzyme A reductase inhibitors in the treatment of hypercholesterolemia

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12 December 2020

CS-514, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase: tissue-selective inhibition of sterol synthesis and hypolipidemic effect on various animal species

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12 December 2020

Tissue selectivity of the cholesterol-lowering agents lovastatin, simvastatin and pravastatin in rats in vivo

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12 December 2020

Inhibition of cholesterol synthesis in vitro and in vivo by ML-236A and ML-236B, competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase

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12 December 2020

Relative Lipophilicities, Solubilities, and Structure–Pharmacological Considerations of 3-Hydroxy-3-Methylglutaryl-Coenzyme A (HMG-CoA) Reductase Inhibitors Pravastatin, Lovastatin, Mevastatin, and Simvastatin

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12 December 2020

Identifiers

DOI

10.1023/A:1023237510458

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27 April 2018

Dimensions Publication ID

1050076736

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27 April 2018