(Q52248721)

English

Inhibition of cellular esterases by the antitumour imidazotetrazines mitozolomide and temozolomide: demonstration by flow cytometry and conventional spectrofluorimetry.

scientific article published in January 1989

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

28 April 2018

http://europepmc.org/abstract/MED/2557170

Inhibition of cellular esterases by the antitumour imidazotetrazines mitozolomide and temozolomide: demonstration by flow cytometry and conventional spectrofluorimetry. (English)

1 reference

Europe PubMed Central

PubMed publication ID

28 April 2018

http://europepmc.org/abstract/MED/2557170

0 references

1 reference

based on heuristic

inferred from title

1

1 reference

Europe PubMed Central

PubMed publication ID

28 April 2018

http://europepmc.org/abstract/MED/2557170

author name string

P Workman

2

1 reference

Europe PubMed Central

PubMed publication ID

28 April 2018

http://europepmc.org/abstract/MED/2557170

J V Watson

3

1 reference

Europe PubMed Central

PubMed publication ID

28 April 2018

http://europepmc.org/abstract/MED/2557170

publication date

1 January 1989

1 reference

Europe PubMed Central

PubMed publication ID

28 April 2018

http://europepmc.org/abstract/MED/2557170

Cancer Chemotherapy and Pharmacology

1 reference

Europe PubMed Central

PubMed publication ID

28 April 2018

http://europepmc.org/abstract/MED/2557170

25

1 reference

Europe PubMed Central

PubMed publication ID

28 April 2018

http://europepmc.org/abstract/MED/2557170

3

1 reference

Europe PubMed Central

PubMed publication ID

28 April 2018

http://europepmc.org/abstract/MED/2557170

149-155

1 reference

Europe PubMed Central

PubMed publication ID

28 April 2018

http://europepmc.org/abstract/MED/2557170

describes a project that uses

1 reference

based on heuristic

inferred from title

https://scigraph.springernature.com/pub.10.1007/bf00689574

0 references

The 1987 Walter Hubert lecture. Regulation and deficiencies in DNA repair

1 reference

https://api.crossref.org/works/10.1007%2FBF00689574

21 January 2018

A study of some variables in a tetrazolium dye (MTT) based assay for cell growth and chemosensitivity

1 reference

https://api.crossref.org/works/10.1007%2FBF00689574

21 January 2018

Increased O6-alkylguanine alkyltransferase activity in Chinese hamster V79 cells following selection with chloroethylating agents.

1 reference

https://pubmed.ncbi.nlm.nih.gov/2557170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction of the toxicity and mutagenicity of alkylating agents in mammalian cells harboring the Escherichia coli alkyltransferase gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/2557170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA sequence selectivity of guanine-N7 alkylation by three antitumor chloroethylating agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/2557170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA damage and differential cytotoxicity produced in human cells by 2-chloroethyl (methylsulfonyl)methanesulfonate (NSC 338947), a new DNA-chloroethylating agent

1 reference

https://pubmed.ncbi.nlm.nih.gov/2557170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA reactivity and in vitro cytotoxicity of the novel antitumor agent 1,5,2,4-dioxadithiepane-2,2,4,4-tetraoxide (NSC-348948) in human embryo cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/2557170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

2-Chloroethyl (methylsulfonyl)methanesulfonate (NSC-338947), a more selective DNA alkylating agent than the chloroethylnitrosoureas

1 reference

https://pubmed.ncbi.nlm.nih.gov/2557170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Improved methodology for intracellular enzyme reaction and inhibition kinetics by flow cytometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/2557170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characteristics of a serially transplanted mouse mammary tumor and its tissue-culture-adapted derivative.

1 reference

https://pubmed.ncbi.nlm.nih.gov/2557170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential cytotoxicity and DNA-damaging effects produced in human cells of the Mer+ and Mer- phenotypes by a series of alkyltriazenylimidazoles

1 reference

https://pubmed.ncbi.nlm.nih.gov/2557170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA cross-linking and cytotoxicity in normal and transformed human cells treated in vitro with 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d] -1,2,3,5-tetrazin-4(3H)-one.

1 reference

https://pubmed.ncbi.nlm.nih.gov/2557170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Experimental antitumor activity against murine tumor model systems of 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3 H)-one (mitozolomide), a novel broad-spectrum agent.

1 reference

https://pubmed.ncbi.nlm.nih.gov/2557170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enzyme kinetic studies in cell populations using fluorogenic substrates and flow cytometric techniques

1 reference

https://pubmed.ncbi.nlm.nih.gov/2557170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumor activity and pharmacokinetics in mice of 8-carbamoyl-3-methyl-imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M & B 39831), a novel drug with potential as an alternative to dacarbazine

1 reference

https://pubmed.ncbi.nlm.nih.gov/2557170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Misonidazole-induced chemopotentiation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea toxicity in O6-methylguanine-DNA methyltransferase proficient (Mer+) and deficient (Mer-) cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/2557170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumour imidazotetrazines--IV. An investigation into the mechanism of antitumour activity of a novel and potent antitumour agent, mitozolomide (CCRG 81010, M & B 39565; NSC 353451).

1 reference

https://pubmed.ncbi.nlm.nih.gov/2557170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A flow cytofluorimetric method for measuring enzyme reaction kinetics in intact cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/2557170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of specific DNA lesions induced by three classes of chloroethylating agents: chloroethylnitrosoureas, chloroethylmethanesulfonates and chloroethylimidazotetrazines

1 reference

https://pubmed.ncbi.nlm.nih.gov/2557170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of intracellular esterases by antitumour chloroethylnitrosoureas

1 reference

https://pubmed.ncbi.nlm.nih.gov/2557170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA crosslinking and cytotoxicity in normal and transformed human cells treated with antitumor nitrosoureas

1 reference

https://pubmed.ncbi.nlm.nih.gov/2557170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel dynamic flow cytoenzymological determination of intracellular esterase inhibition by BCNU and related isocyanates

1 reference

https://pubmed.ncbi.nlm.nih.gov/2557170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumour imidazotetrazines. VII. Quantitative analysis of mitozolomide in biological fluids by high-performance liquid chromatography

1 reference

https://pubmed.ncbi.nlm.nih.gov/2557170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumor imidazotetrazines. 1. Synthesis and chemistry of 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3 H)-one , a novel broad-spectrum antitumor agent

1 reference

https://pubmed.ncbi.nlm.nih.gov/2557170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dual laser beam focussing for flow cytometry through a single crossed cylindrical lens pair

1 reference

https://pubmed.ncbi.nlm.nih.gov/2557170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional expression of the Escherichia coli alkyltransferase gene in mammalian cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/2557170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/BF00689574

1 reference

Europe PubMed Central

PubMed publication ID

28 April 2018

http://europepmc.org/abstract/MED/2557170

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 April 2018

http://europepmc.org/abstract/MED/2557170

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