(Q52506174)

2 May 2018

title

Prediction of ACNU plasma concentration-time profiles in humans by animal scale-up. (English)

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2 May 2018

author name string

Y Mitsuhashi

1

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2 May 2018

Y Sugiyama

2

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2 May 2018

S Ozawa

3

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2 May 2018

T Nitanai

4

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2 May 2018

K Sasahara

5

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2 May 2018

K Nakamura

6

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2 May 2018

M Tanaka

7

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2 May 2018

T Nishimura

8

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2 May 2018

M Inaba

9

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2 May 2018

T Kobayashi

10

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2 May 2018

publication date

1 January 1990

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2 May 2018

Cancer Chemotherapy and Pharmacology

published in

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2 May 2018

volume

27

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2 May 2018

page(s)

20-26

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2 May 2018

issue

1

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2 May 2018

https://scigraph.springernature.com/pub.10.1007/bf00689271

exact match

0 references

cites work

Identification of major urinary metabolites of ACNU, 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitroso urea hydrochloride in rats

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Cell killing action of cell cycle phase-non-specific antitumor agents is dependent on concentration--time product.

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Interspecies pharmacokinetic scaling and the evolutionary-comparative paradigm

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12 December 2020

Physiologic pharmacokinetic models and interanimal species scaling

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12 December 2020

In vitro metabolism of ACNU, 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitroso urea hydrochloride, a water-soluble antitumor nitrosourea

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12 December 2020

Interspecies scaling, allometry, physiological time, and the ground plan of pharmacokinetics.

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A pharmacokinetic analysis program (multi) for microcomputer.

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Dosage regimen design for pharmaceutical studies conducted in animals.

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Pharmacokinetic approach to rational therapeutic doses for human tumor-bearing nude mice.

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Prediction of the disposition of beta-lactam antibiotics in humans from pharmacokinetic parameters in animals

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12 December 2020

Evaluation of antitumor activity in a human breast tumor/nude mouse model with a special emphasis on treatment dose

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12 December 2020

Man versus beast: pharmacokinetic scaling in mammals

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12 December 2020

Responsiveness of human gastric tumors implanted in nude mice to clinically equivalent doses of various antitumor agents.

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12 December 2020

Distribution, excretion, and metabolism of 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitrosourea (ACNU) in rats and mice after iv administration

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12 December 2020

Influence of modes of ACNU administration on tissue and blood drug concentration in malignant brain tumors.

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12 December 2020

Interspecies pharmacokinetic scaling and the Dedrick plots

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12 December 2020

Identifiers

DOI

10.1007/BF00689271

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2 May 2018

PubMed ID

2245489

1 reference

2 May 2018