(Q52535316)

2 May 2018

title

Age-related impaired proliferation of peripheral blood mononuclear cells is associated with an increase in both IL-10 and IL-12. (English)

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2 May 2018

author name string

Castle SC

1

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2 May 2018

Uyemura K

2

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2 May 2018

Crawford W

3

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2 May 2018

Wong W

4

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2 May 2018

Klaustermeyer WB

5

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2 May 2018

Makinodan T

6

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2 May 2018

publication date

1 April 1999

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2 May 2018

published in

Experimental Gerontology

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2 May 2018

volume

34

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2 May 2018

issue

2

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2 May 2018

page(s)

243-252

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2 May 2018

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Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression

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Autoantibody production in healthy elderly people is not promoted by interleukin-10 although this cytokine is expressed in them by a peculiar CD8+CD3+ large granular cell subpopulation

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Interleukin 12 and B7/CD28 interaction synergistically upregulate interleukin 10 production by human T cells.

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IL-12 directly stimulates expression of IL-10 by CD5+ B cells and IL-6 by both CD5+ and CD5- B cells: possible involvement in age-associated cytokine dysregulation

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Dysregulation of IL-10 production with aging: possible linkage to the age-associated decline in DHEA and its sulfated derivative

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Identifiers

DOI

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2 May 2018

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2 May 2018