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English
Presenilin mutations line up along transmembrane alpha-helices.
scientific article published in June 2001
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Statements
instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11406330
retrieved
3 May 2018
reference URL
http://europepmc.org/abstract/MED/11406330
title
Presenilin mutations line up along transmembrane alpha-helices.
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11406330
retrieved
3 May 2018
reference URL
http://europepmc.org/abstract/MED/11406330
main subject
transmembrane protein
0 references
author name string
Hardy J
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11406330
retrieved
3 May 2018
reference URL
http://europepmc.org/abstract/MED/11406330
Crook R
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11406330
retrieved
3 May 2018
reference URL
http://europepmc.org/abstract/MED/11406330
language of work or name
English
0 references
publication date
1 June 2001
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11406330
retrieved
3 May 2018
reference URL
http://europepmc.org/abstract/MED/11406330
published in
Neuroscience Letters
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11406330
retrieved
3 May 2018
reference URL
http://europepmc.org/abstract/MED/11406330
volume
306
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11406330
retrieved
3 May 2018
reference URL
http://europepmc.org/abstract/MED/11406330
issue
3
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11406330
retrieved
3 May 2018
reference URL
http://europepmc.org/abstract/MED/11406330
page(s)
203-205
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11406330
retrieved
3 May 2018
reference URL
http://europepmc.org/abstract/MED/11406330
cites work
The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-3940%2801%2901910-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Early-onset Alzheimer's disease with a presenilin-1 mutation at the site corresponding to the Volga German presenilin-2 mutation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-3940%2801%2901910-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular genetics of Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-3940%2801%2901910-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-3940%2801%2901910-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Amyloid, the presenilins and Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-3940%2801%2901910-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-3940%2801%2901910-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The presenilin 1 C92S mutation increases abeta 42 production.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-3940%2801%2901910-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-3940%2801%2901910-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-3940%2801%2901910-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A loss of function mutant of the presenilin homologue SEL-12 undergoes aberrant endoproteolysis in Caenorhabditis elegans and increases abeta 42 generation in human cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-3940%2801%2901910-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A further presenilin 1 mutation in the exon 8 cluster in familial Alzheimer's disease.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-3940%2801%2901910-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Antisense-induced reduction of presenilin 1 expression selectively increases the production of amyloid beta42 in transfected cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-3940%2801%2901910-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-3940%2801%2901910-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-3940%2801%2901910-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-3940%2801%2901910-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-3940%2801%2901910-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0304-3940(01)01910-3
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11406330
retrieved
3 May 2018
reference URL
http://europepmc.org/abstract/MED/11406330
PubMed publication ID
11406330
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11406330
retrieved
3 May 2018
reference URL
http://europepmc.org/abstract/MED/11406330
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