(Q52595328)

4 May 2018

review article

1 reference

title

Chemotherapy of human african trypanosomiasis. (English)

1 reference

4 May 2018

main subject

trypanosomiasis

0 references

African trypanosomiasis

0 references

1 reference

Cyrus J Bacchi

1

1 reference

4 May 2018

publication date

20 August 2009

1 reference

4 May 2018

Interdisciplinary Perspectives on Infectious Diseases

published in

1 reference

4 May 2018

volume

2009

1 reference

4 May 2018

page(s)

195040

1 reference

4 May 2018

Creative Commons Attribution 3.0 Unported

copyright license

start time

1 January 2009

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

1 reference

April 2022 Public Data File from Crossref

cites work

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Safety and effectiveness of first line eflornithine for Trypanosoma brucei gambiense sleeping sickness in Sudan: cohort study

22 May 2018

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Nifurtimox plus Eflornithine for late-stage sleeping sickness in Uganda: a case series

22 May 2018

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Human African trypanosomiasis: pharmacological re-engagement with a neglected disease.

22 May 2018

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Drugs and drug resistance in African trypanosomiasis

22 May 2018

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Three drug combinations for late-stage Trypanosoma brucei gambiense sleeping sickness: a randomized clinical trial in Uganda

22 May 2018

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A burgeoning epidemic of sleeping sickness in Uganda

22 May 2018

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Eflornithine is safer than melarsoprol for the treatment of second-stage Trypanosoma brucei gambiense human African trypanosomiasis

22 May 2018

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Uptake of pentamidine in Trypanosoma brucei brucei is mediated by three distinct transporters: implications for cross-resistance with arsenicals

22 May 2018

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Multiple mechanisms of immune evasion by African trypanosomes

22 May 2018

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Alterations in ornithine decarboxylase characteristics account for tolerance of Trypanosoma brucei rhodesiense to D,L-alpha-difluoromethylornithine.

22 May 2018

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Combination chemotherapy of drug-resistant Trypanosoma brucei rhodesiense infections in mice using DL-alpha-difluoromethylornithine and standard trypanocides.

22 May 2018

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The treatment of human African trypanosomiasis

22 May 2018

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22 May 2018

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Molecular mechanisms and therapeutic approaches to the treatment of African trypanosomiasis

22 May 2018

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Uptake of diamidine drugs by the P2 nucleoside transporter in melarsen-sensitive and -resistant Trypanosoma brucei brucei

22 May 2018

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Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids

22 May 2018

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Uptake of alpha-difluoromethylornithine by Trypanosoma brucei brucei

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730475

Trypanothione is the primary target for arsenical drugs against African trypanosomes

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730475

Trypanosome ornithine decarboxylase is stable because it lacks sequences found in the carboxyl terminus of the mouse enzyme which target the latter for intracellular degradation.

22 May 2018

1 reference

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Differential susceptibility to DL-alpha-difluoromethylornithine in clinical isolates of Trypanosoma brucei rhodesiense

22 May 2018

1 reference

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Towards more efficacious chemotherapy of trypanosomiasis: Combination of alpha-difluoromethylornithine (DFMO) with reactive oxygen generating drugs

22 May 2018

1 reference

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Characterisation of melarsen-resistant Trypanosoma brucei brucei with respect to cross-resistance to other drugs and trypanothione metabolism

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730475

Effects of the ornithine decarboxylase inhibitors DL-alpha-difluoromethylornithine and alpha-monofluoromethyldehydroornithine methyl ester alone and in combination with suramin against Trypanosoma brucei brucei central nervous system models.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730475

Advances in sleeping sickness therapy

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730475

A Trypanosoma brucei mutant resistant to alpha-difluoromethylornithine.

22 May 2018

1 reference

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Melarsoprol-free drug combinations for second-stage Gambian sleeping sickness: the way to go.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730475

Nifurtimox-eflornithine combination therapy for second-stage Trypanosoma brucei gambiense sleeping sickness: a randomized clinical trial in Congo

13 August 2018

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In vivo effects of alpha-DL-difluoromethylornithine on the metabolism and morphology of Trypanosoma brucei brucei.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730475

Development of drug resistance in Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense. Treatment of human African trypanosomiasis with natural products (Review)

13 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1155%2F2009%2F195040

The uptake of the trypanocidal drug suramin in combination with low-density lipoproteins by Trypanosoma brucei and its possible mode of action

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1155%2F2009%2F195040

In vivo effects of difluoromethylornithine on trypanothione and polyamine levels in bloodstream forms of Trypanosoma brucei

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1155%2F2009%2F195040

Immunobiology of African trypanosomiasis

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730475

Polyamine metabolism: a potential therapeutic target in trypanosomes

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730475

New drug combination for experimental late-stage African trypanosomiasis: DL-alpha-difluoromethylornithine (DFMO) with suramin

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730475

Necessity of antibody response in the treatment of African trypanosomiasis with alpha-difluoromethylornithine

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730475

Drugs for parasitic infections

30 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19707529

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1155/2009/195040

1 reference

4 May 2018

release_kodvn4sndjajzb53pcwhqqxega

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/kodvn4sndjajzb53pcwhqqxega

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMC publication ID

2730475

1 reference

4 May 2018

PubMed publication ID

19707529

1 reference

4 May 2018