(Q52665459)

http://europepmc.org/abstract/MED/26571108

5 May 2018

title

Polyalanine expansions drive a shift into α-helical clusters without amyloid-fibril formation. (English)

1 reference

http://europepmc.org/abstract/MED/26571108

5 May 2018

author

Andrew F. Hill

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26571108%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Till Böcking

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26571108%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Cheryl Shoubridge

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26571108%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Michael Griffin

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26571108%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Danny M. Hatters

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26571108%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

author name string

Saskia Polling

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26571108%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Angelique R Ormsby

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26571108%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Rebecca J Wood

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26571108%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Kristie Lee

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26571108%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

James N Hughes

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26571108%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Paul Q Thomas

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26571108%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Quill Bowden

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26571108%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

publication date

16 November 2015

1 reference

http://europepmc.org/abstract/MED/26571108

5 May 2018

published in

Nature Structural & Molecular Biology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26571108%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

volume

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26571108%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

issue

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26571108%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

page(s)

1008-1015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26571108%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nsmb.3127

7 June 2020

exact match

0 references

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Unraveling the pathogenesis of ARX polyalanine tract variants using a clinical and molecular interfacing approach

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Polyalanine expansion mutations in the X-linked hypopituitarism gene SOX3 result in aggresome formation and impaired transactivation.

21 January 2018

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Reduced polyalanine-expanded Arx mutant protein in developing mouse subpallium alters Lmo1 transcriptional regulation

21 January 2018

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Protein misfolding, functional amyloid, and human disease

21 January 2018

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A molecular pathogenesis for transcription factor associated poly-alanine tract expansions

21 January 2018

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Distinct pathogenetic mechanisms for PHOX2B associated polyalanine expansions and frameshift mutations in congenital central hypoventilation syndrome

21 January 2018

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A recurrent polyalanine expansion in the transcription factor FOXL2 induces extensive nuclear and cytoplasmic protein aggregation

21 January 2018

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A novel feed-forward loop between ARIH2 E3-ligase and PABPN1 regulates aging-associated muscle degeneration

21 January 2018

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21 January 2018

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Trinucleotide expansions leading to an extended poly-L-alanine segment in the poly (A) binding protein PABPN1 cause fibril formation

21 January 2018

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The unresolved puzzle why alanine extensions cause disease

21 January 2018

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Oligomerization of polyalanine expanded PABPN1 facilitates nuclear protein aggregation that is associated with cell death

21 January 2018

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The two-stage pathway of ataxin-3 fibrillogenesis involves a polyglutamine-independent step.

21 January 2018

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Mechanistic insight into the pathology of polyalanine expansion disorders revealed by a mouse model for X linked hypopituitarism

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A platform to view huntingtin exon 1 aggregation flux in the cell reveals divergent influences from chaperones hsp40 and hsp70.

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Three human ARX mutations cause the lissencephaly-like and mental retardation with epilepsy-like pleiotropic phenotypes in mice.

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21 January 2018

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21 January 2018

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Mutation of ARX causes abnormal development of forebrain and testes in mice and X-linked lissencephaly with abnormal genitalia in humans

21 January 2018

1 reference

Polyalanine tract disorders and neurocognitive phenotypes

21 January 2018

2 references

https://pubmed.ncbi.nlm.nih.gov/26571108

21 January 2018

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The Rate of PolyQ-Mediated Aggregation Is Dramatically Affected by the Number and Location of Surrounding Domains

1 reference

Length-dependent aggregation of uninterrupted polyalanine peptides

21 January 2018

1 reference

Determination of the sedimentation coefficient distribution by least-squares boundary modeling

31 March 2020

1 reference

Molecular characterization of HOXA13 polyalanine expansion proteins in hand-foot-genital syndrome

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NSMB.3127

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26571108%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

1 reference