(Q52948211)

9 May 2018

title

Eosinophils orchestrate cancer rejection by normalizing tumor vessels and enhancing infiltration of CD8(+) T cells. (English)

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9 May 2018

author name string

Rafael Carretero

1

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9 May 2018

Ibrahim M Sektioglu

2

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9 May 2018

Natalio Garbi

3

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9 May 2018

Oscar C Salgado

4

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9 May 2018

Philipp Beckhove

5

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9 May 2018

Günter J Hämmerling

6

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9 May 2018

language of work or name

English

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publication date

27 April 2015

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9 May 2018

published in

Nature Immunology

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9 May 2018

volume

16

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9 May 2018

issue

6

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9 May 2018

page(s)

609-617

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9 May 2018

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Eosinophils: changing perspectives in health and disease

21 January 2018

1 reference

Eosinophils: multifaceted biological properties and roles in health and disease

21 January 2018

1 reference

Eosinophil-derived cytokines in health and disease: unraveling novel mechanisms of selective secretion

21 January 2018

1 reference

Regulation of carcinogenesis by IL-5 and CCL11: a potential role for eosinophils in tumor immune surveillance.

21 January 2018

1 reference

Pivotal Advance: eosinophil infiltration of solid tumors is an early and persistent inflammatory host response

21 January 2018

1 reference

Eosinophils oxidize damage-associated molecular pattern molecules derived from stressed cells

21 January 2018

1 reference

Eosinophilic granulocytes and damage-associated molecular pattern molecules (DAMPs): role in the inflammatory response within tumors

21 January 2018

1 reference

Immune-escape markers in relation to clinical outcome of advanced melanoma patients following immunotherapy.

21 January 2018

1 reference

Involvement of eosinophils in the anti-tumor response

21 January 2018

1 reference

Treatment of established renal cancer by tumor cells engineered to secrete interleukin-4.

21 January 2018

1 reference

Immunotherapy of cytotoxic T cell-resistant tumors by T helper 2 cells: an eotaxin and STAT6-dependent process.

21 January 2018

1 reference

Increased blood clotting, microvascular density, and inflammation in eotaxin-secreting tumors implanted into mice

21 January 2018

1 reference

Tumor associated macrophages and neutrophils in cancer

21 January 2018

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Siglec-F antibody administration to mice selectively reduces blood and tissue eosinophils

21 January 2018

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Eosinophils are required for the maintenance of plasma cells in the bone marrow.

21 January 2018

1 reference

Eosinophils: 'new' roles for 'old' cells

21 January 2018

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Adoptive immunotherapy for cancer: harnessing the T cell response

21 January 2018

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Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy

21 January 2018

1 reference

Multiple defects of immune cell function in mice with disrupted interferon-gamma genes

21 January 2018

1 reference

Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis

21 January 2018

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The impact of the immune system on tumor: angiogenesis and vascular remodeling

21 January 2018

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Vascular normalization as an emerging strategy to enhance cancer immunotherapy

21 January 2018

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Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells.

21 January 2018

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Coordinated regulation of myeloid cells by tumours

21 January 2018

1 reference

Low-dose irradiation programs macrophage differentiation to an iNOS⁺/M1 phenotype that orchestrates effective T cell immunotherapy

21 January 2018

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CpG motifs as proinflammatory factors render autochthonous tumors permissive for infiltration and destruction

21 January 2018

1 reference

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells

21 January 2018

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Combining antiangiogenic therapy with adoptive cell immunotherapy exerts better antitumor effects in non-small cell lung cancer models

21 January 2018

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Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy

21 January 2018

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Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis

21 January 2018

1 reference

Deciphering and reversing tumor immune suppression.

21 January 2018

1 reference

Prognostic and predictive impact of intra- and peritumoral immune infiltrates

21 January 2018

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Complete regression of advanced primary and metastatic mouse melanomas following combination chemoimmunotherapy.

21 January 2018

1 reference

Intratumoral Cytokines and Tumor Cell Biology Determine Spontaneous Breast Cancer-Specific Immune Responses and Their Correlation to Prognosis

21 January 2018

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Vascular normalization in Rgs5-deficient tumours promotes immune destruction

21 January 2018

1 reference

An eosinophil-dependent mechanism for the antitumor effect of interleukin-4

21 January 2018

1 reference

12 December 2020

Tumor-associated eosinophilia in interleukin-2-treated patients: evidence of toxic eosinophil degranulation on bladder cancer cells

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12 December 2020

Transformation of the microvascular system during multistage tumorigenesis

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12 December 2020

Neutrophils but not eosinophils are involved in growth suppression of IL-4-secreting tumors

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12 December 2020

Combination of T-cell therapy and trigger of inflammation induces remodeling of the vasculature and tumor eradication.

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12 December 2020

Evidence for eosinophil activation in cancer patients receiving recombinant interleukin-4: effects of interleukin-4 alone and following interleukin-2 administration

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12 December 2020

Dendritic cells support homeostatic expansion of Foxp3+ regulatory T cells in Foxp3.LuciDTR mice

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12 December 2020

Efficient Treg depletion induces T-cell infiltration and rejection of large tumors

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12 December 2020

Eosinophils and cancer.

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12 December 2020

Experience in daily practice with ipilimumab for the treatment of patients with metastatic melanoma: an early increase in lymphocyte and eosinophil counts is associated with improved survival

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12 December 2020

Generation of Th1 and Th2 chemokines by human eosinophils: evidence for a critical role of TNF-alpha

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12 December 2020

Eosinophils infiltrating interleukin-5 gene-transfected tumors do not suppress tumor growth

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12 December 2020

Identifiers

DOI

10.1038/NI.3159

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9 May 2018

PubMed ID

25915731

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9 May 2018