(Q52958424)

9 May 2018

title

An inhibitor of stress-activated MAP-kinases reduces invasion and MMP-2 expression of malignant melanoma cells. (English)

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9 May 2018

author

Carsten Denkert

1

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9 May 2018

author name string

Antje Siegert

2

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9 May 2018

Anja Leclere

3

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9 May 2018

Andreas Turzynski

4

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Steffen Hauptmann

5

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9 May 2018

publication date

1 January 2002

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9 May 2018

Clinical & Experimental Metastasis

published in

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9 May 2018

volume

19

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issue

1

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page(s)

79-85

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9 May 2018

https://scigraph.springernature.com/pub.10.1023/a:1013857325012

exact match

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cites work

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The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activate

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Reconstitution of novel signalling cascades responding to cellular stresses

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Prognostic value of MMP-2 immunoreactive protein (72 kD type IV collagenase) in primary skin melanoma.

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Inhibition of the p38 mitogen-activated protein kinase by SB 203580 blocks PMA-induced Mr 92,000 type IV collagenase secretion and in vitro invasion

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Differentiation in vivo of classical non-steroidal antiinflammatory drugs from cytokine suppressive antiinflammatory drugs and other pharmacological classes using mouse tumour necrosis factor alpha production

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SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1

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12 December 2020

Inhibition of the mitogen-activated protein kinase pathway triggers B16 melanoma cell differentiation.

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A model of human cancer metastasis: extensive spontaneous and artificial metastasis of a human pigmented melanoma and derived variant sublines in nude mice

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The 72 kDa type IV collagenase is modulated via differential expression of alpha v beta 3 and alpha 5 beta 1 integrins during human melanoma cell invasion.

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Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function

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Interleukin-1beta regulation of inducible nitric oxide synthase and cyclooxygenase-2 involves the p42/44 and p38 MAPK signaling pathways in cardiac myocytes

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The p38-MAPK inhibitor, SB203580, inhibits cardiac stress-activated protein kinases/c-Jun N-terminal kinases (SAPKs/JNKs)

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The involvement of p38 mitogen-activated protein kinase in the alpha-melanocyte stimulating hormone (alpha-MSH)-induced melanogenic and anti-proliferative effects in B16 murine melanoma cells

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Mitogen-activated protein kinases mediate matrix metalloproteinase-9 expression in vascular smooth muscle cells

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A modified invasion-3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide assay for quantitating tumor cell invasion.

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12 December 2020

Activation of fibroblast collagenase-1 expression by tumor cells of squamous cell carcinomas is mediated by p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase-2

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12 December 2020

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12 December 2020

Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kappaB: differential regulation of collagenase 1 and collagenase 3

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12 December 2020

Identifiers

DOI

10.1023/A:1013857325012

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9 May 2018

Dimensions Publication ID

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9 May 2018