(Q53019029)

English

The high sensitivity of the rabbit to the teratogenic effects of 13-cis-retinoic acid (isotretinoin) is a consequence of prolonged exposure of the embryo to 13-cis-retinoic acid and 13-cis-4-oxo-retinoic acid, and not of isomerization to all-trans-r

scientific article published in January 1994

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

10 May 2018

http://europepmc.org/abstract/MED/8179481

The high sensitivity of the rabbit to the teratogenic effects of 13-cis-retinoic acid (isotretinoin) is a consequence of prolonged exposure of the embryo to 13-cis-retinoic acid and 13-cis-4-oxo-retinoic acid, and not of isomerization to all-trans-r (English)

1 reference

Europe PubMed Central

PubMed publication ID

10 May 2018

http://europepmc.org/abstract/MED/8179481

0 references

author name string

G Tzimas

1

1 reference

Europe PubMed Central

PubMed publication ID

10 May 2018

http://europepmc.org/abstract/MED/8179481

H Bürgin

2

1 reference

Europe PubMed Central

PubMed publication ID

10 May 2018

http://europepmc.org/abstract/MED/8179481

M D Collins

3

1 reference

Europe PubMed Central

PubMed publication ID

10 May 2018

http://europepmc.org/abstract/MED/8179481

H Hummler

4

1 reference

Europe PubMed Central

PubMed publication ID

10 May 2018

http://europepmc.org/abstract/MED/8179481

H Nau

5

1 reference

Europe PubMed Central

PubMed publication ID

10 May 2018

http://europepmc.org/abstract/MED/8179481

publication date

1 January 1994

1 reference

Europe PubMed Central

PubMed publication ID

10 May 2018

http://europepmc.org/abstract/MED/8179481

Archives of Toxicology

1 reference

Europe PubMed Central

PubMed publication ID

10 May 2018

http://europepmc.org/abstract/MED/8179481

68

1 reference

Europe PubMed Central

PubMed publication ID

10 May 2018

http://europepmc.org/abstract/MED/8179481

2

1 reference

Europe PubMed Central

PubMed publication ID

10 May 2018

http://europepmc.org/abstract/MED/8179481

119-128

1 reference

Europe PubMed Central

PubMed publication ID

10 May 2018

http://europepmc.org/abstract/MED/8179481

https://scigraph.springernature.com/pub.10.1007/s002040050044

0 references

Metabolism in vivo of all-trans-[11-3H]retinoic acid after an oral dose in rats. Characterization of retinoyl β-glucuronide in the blood and other tissues

1 reference

https://api.crossref.org/works/10.1007%2FS002040050044

21 January 2018

Retinoids in cancer prevention and therapy

1 reference

https://api.crossref.org/works/10.1007%2FS002040050044

21 January 2018

Intracellular vitamin A--binding proteins

1 reference

https://api.crossref.org/works/10.1007%2FS002040050044

21 January 2018

Comparative teratology and transplacental pharmacokinetics of all-trans-retinoic acid, 13-cis-retinoic acid, and retinyl palmitate following daily administrations in rats

1 reference

https://api.crossref.org/works/10.1007%2FS002040050044

21 January 2018

Teratogenicity and placental transfer of all-trans-, 13-cis-, 4-oxo-all-trans-, and 4-oxo-13-cis-retinoic acid after administration of a low oral dose during organogenesis in mice

1 reference

https://api.crossref.org/works/10.1007%2FS002040050044

21 January 2018

Transplacental pharmacokinetics and teratogenicity of a single dose of retinol (vitamin A) during organogenesis in the mouse.

1 reference

https://api.crossref.org/works/10.1007%2FS002040050044

21 January 2018

Characterization of oxidized and glucuronidated metabolites of retinol in monkey plasma by thermospray liquid chromatography/mass spectrometry.

1 reference

https://api.crossref.org/works/10.1007%2FS002040050044

21 January 2018

Influence of dose and pharmaceutical formulation of vitamin A on plasma levels of retinyl esters and retinol and metabolic generation of retinoic acid compounds and beta-glucuronides in the cynomolgus monkey.

1 reference

https://api.crossref.org/works/10.1007%2FS002040050044

21 January 2018

Retinoids and vertebrate limb pattern formation

1 reference

https://api.crossref.org/works/10.1007%2FS002040050044

21 January 2018

Hypervitaminosis A Induced Teratogenesis

1 reference

https://api.crossref.org/works/10.1007%2FS002040050044

21 January 2018

Teratogenicity of all-trans retinoic acid during early embryonic development in the cynomolgus monkey (Macaca fascicularis).

1 reference

https://api.crossref.org/works/10.1007%2FS002040050044

21 January 2018

Structure-activity relationships of retinoids in developmental toxicology. III. Contribution of the vitamin A beta-cyclogeranylidene ring

1 reference

https://api.crossref.org/works/10.1007%2FS002040050044

21 January 2018

Induction of malformations in the cynomolgus monkey with 13-cis retinoic acid

1 reference

https://api.crossref.org/works/10.1007%2FS002040050044

21 January 2018

Teratogenesis and reproductive safety evaluation of the retinoid etretin (Ro 10-1670).

1 reference

https://api.crossref.org/works/10.1007%2FS002040050044

21 January 2018

Developmental effects of isotretinoin and 4-oxo-isotretinoin: the role of metabolism in teratogenicity.

1 reference

https://api.crossref.org/works/10.1007%2FS002040050044

21 January 2018

Retinoic acid embryopathy

1 reference

https://api.crossref.org/works/10.1007%2FS002040050044

21 January 2018

A test procedure based on ranks for the statistical evaluation of toxicological studies.

1 reference

https://api.crossref.org/works/10.1007%2FS002040050044

21 January 2018

Retinoid receptors in vertebrate limb development

1 reference

https://api.crossref.org/works/10.1007%2FS002040050044

21 January 2018

Physiological occurrence, biosynthesis and metabolism of retinoic acid: evidence for roles of cellular retinol-binding protein (CRBP) and cellular retinoic acid-binding protein (CRABP) in the pathway of retinoic acid homeostasis

1 reference

https://api.crossref.org/works/10.1007%2FS002040050044

21 January 2018

Species differences in pharmacokinetics and drug teratogenesis

1 reference

https://api.crossref.org/works/10.1007%2FS002040050044

21 January 2018

Local application of retinoic acid to the limb bond mimics the action of the polarizing region

1 reference

https://api.crossref.org/works/10.1007%2FS002040050044

21 January 2018

Taurine failed to protect against the embryotoxic effects of isotretinoin in the rat

1 reference

https://api.crossref.org/works/10.1007%2FS002040050044

21 January 2018

Vitamin A and retinoids: from nutrition to pharmacotherapy in dermatology and oncology

1 reference

https://api.crossref.org/works/10.1007%2FS002040050044

21 January 2018

4-Methylpyrazole partially ameliorated the teratogenicity of retinol and reduced the metabolic formation of all-trans-retinoic acid in the mouse

1 reference

https://api.crossref.org/works/10.1007%2FS002040050044

21 January 2018

Isotretinoin (13-cis-retinoic acid) metabolism, cis-trans isomerization, glucuronidation, and transfer to the mouse embryo: consequences for teratogenicity

1 reference

https://api.crossref.org/works/10.1007%2FS002040050044

21 January 2018

Comparative distribution, pharmacokinetics and placental permeabilities of all-trans-retinoic acid, 13-cis-retinoic acid, all-trans-4-oxo-retinoic acid, retinyl acetate and 9-cis-retinal in hamsters

1 reference

https://api.crossref.org/works/10.1007%2FS002040050044

21 January 2018

Toxicology, carcinogenicity, and teratogenicity of some orally administered retinoids.

1 reference

https://api.crossref.org/works/10.1007%2FS002040050044

21 January 2018

Importance of early exposure to 13-cis retinoic acid to induce teratogenicity in the cynomolgus monkey

1 reference

https://api.crossref.org/works/10.1007%2FS002040050044

21 January 2018

Correlation of transplacental and maternal pharmacokinetics of retinoids during organogenesis with teratogenicity

1 reference

https://api.crossref.org/works/10.1007%2FS002040050044

21 January 2018

Recommendations for isotretinoin use in women of childbearing potential

1 reference

https://api.crossref.org/works/10.1007%2FS002040050044

21 January 2018

Morphogenesis of malformations in hamsters caused by retinoic acid: relation to dose and stage at treatment

1 reference

https://api.crossref.org/works/10.1007%2FS002040050044

21 January 2018

13-cis-retinoic acid is an endogenous compound in human serum.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8179481

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification and quantitation of all-trans- and 13-cis-retinoic acid and 13-cis-4-oxoretinoic acid in human plasma

1 reference

https://pubmed.ncbi.nlm.nih.gov/8179481

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of phenobarbital, 3-methylcholanthrene, and retinoid pretreatment on disposition of orally administered retinoids in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/8179481

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of 4-oxo-13-cis-retinoic acid as the major metabolite of 13-cis-retinoic acid in human blood

1 reference

https://pubmed.ncbi.nlm.nih.gov/8179481

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Teratogenicity of steady-state concentrations of etretinate and metabolite acitretin maintained in maternal plasma and embryo by intragastric infusion during organogenesis in the mouse: a possible model for the extended elimination phase in human th

1 reference

https://pubmed.ncbi.nlm.nih.gov/8179481

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Retinoic acid receptors and cellular retinoid binding proteins. I. A systematic study of their differential pattern of transcription during mouse organogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/8179481

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Retinoids and their receptors in differentiation, embryogenesis, and neoplasia

1 reference

https://pubmed.ncbi.nlm.nih.gov/8179481

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma pharmacokinetics and metabolism of 13-cis- and all-trans-retinoic acid in the cynomolgus monkey and the identification of 13-cis- and all-trans-retinoyl-beta-glucuronides. A comparison to one human case study with isotretinoin

1 reference

https://pubmed.ncbi.nlm.nih.gov/8179481

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The involvement of retinoic acid in the development of the vertebrate central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/8179481

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of retinoid-binding proteins in the generation of pattern in the developing limb, the regenerating limb and the nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/8179481

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S002040050044

1 reference

Europe PubMed Central

PubMed publication ID

10 May 2018

http://europepmc.org/abstract/MED/8179481

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

10 May 2018

http://europepmc.org/abstract/MED/8179481

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