(Q53036641)

English

Pharmacokinetic study of methotrexate, folinic acid and their serum metabolites in children treated with high-dose methotrexate and leucovorin rescue.

scientific article published in January 1990

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

10 May 2018

http://europepmc.org/abstract/MED/2076721

Pharmacokinetic study of methotrexate, folinic acid and their serum metabolites in children treated with high-dose methotrexate and leucovorin rescue. (English)

1 reference

Europe PubMed Central

PubMed publication ID

10 May 2018

http://europepmc.org/abstract/MED/2076721

1 reference

based on heuristic

inferred from title

pharmacokinetics

1 reference

based on heuristic

inferred from title

author name string

C Wolfrom

1

1 reference

Europe PubMed Central

PubMed publication ID

10 May 2018

http://europepmc.org/abstract/MED/2076721

R Hepp

2

1 reference

Europe PubMed Central

PubMed publication ID

10 May 2018

http://europepmc.org/abstract/MED/2076721

R Hartmann

3

1 reference

Europe PubMed Central

PubMed publication ID

10 May 2018

http://europepmc.org/abstract/MED/2076721

H Breithaupt

4

1 reference

Europe PubMed Central

PubMed publication ID

10 May 2018

http://europepmc.org/abstract/MED/2076721

G Henze

5

1 reference

Europe PubMed Central

PubMed publication ID

10 May 2018

http://europepmc.org/abstract/MED/2076721

publication date

1 January 1990

1 reference

Europe PubMed Central

PubMed publication ID

10 May 2018

http://europepmc.org/abstract/MED/2076721

European Journal of Clinical Pharmacology

1 reference

Europe PubMed Central

PubMed publication ID

10 May 2018

http://europepmc.org/abstract/MED/2076721

39

1 reference

Europe PubMed Central

PubMed publication ID

10 May 2018

http://europepmc.org/abstract/MED/2076721

4

1 reference

Europe PubMed Central

PubMed publication ID

10 May 2018

http://europepmc.org/abstract/MED/2076721

377-383

1 reference

Europe PubMed Central

PubMed publication ID

10 May 2018

http://europepmc.org/abstract/MED/2076721

Folate and methotrexate polyglutamate tissue levels in rhesus monkeys following chronic low-dose methotrexate.

1 reference

https://api.crossref.org/works/10.1007%2FBF00315414

21 January 2018

Direct resolution of the stereoisomers of leucovorin and 5-methyltetrahydrofolate using a bovine serum albumin high-performance liquid chromatographic chiral stationary phase coupled to an achiral phenyl column

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Similar specificity of membrane transport for folate analogues and their metabolites by murine and human tumor cells: a clinically directed laboratory study

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma methotrexate as determined by liquid chromatography, enzyme-inhibition assay, and radioimmunoassay after high-dose infusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accumulation of tetrahydrofolates in human plasma after leucovorin administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced citrovorum factor rescue for high-dose methotrexate therapy in childhood malignancies

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro formation of polyglutamyl derivatives of methotrexate and 7-hydroxymethotrexate in human lymphoblastic leukemia cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A direct analysis of methotrexate, dichloromethotrexate and their 7-hydroxy metabolites in plasma by high pressure liquid chromatography

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma kinetic study of folinic acid and 5-methyltetrahydrofolate in healthy volunteers and cancer patients by high-performance liquid chromatography

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exchange between Parenteral and Tissue Folate in Man

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetic and clinical studies of 24-h infusions of high-dose methotrexate

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A simple preparation of the methotrexate metabolites 7-hydroxymethotrexate and 4-deoxy-4-amino-N10-methylpteroic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

7-Hydroxymethotrexate as a urinary metabolite in human subjects and rhesus monkeys receiving high dose methotrexate

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum distribution of citrovorum factor and 5-methyltetrahydrofolate following oral and im administration of calcium leucovorin in normal adults

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and properties of 7-hydroxymethotrexate polyglutamyl derivatives in Ehrlich ascites tumor cells in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions between 7-hydroxymethotrexate and methotrexate at the cellular level in the Ehrlich ascites tumor in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transport of folate compounds by leukemic cells. Evidence for a single influx carrier for methotrexate, 5-methyltetrahydrofolate, and folate in CCRF-CEM human lymphoblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A rapid, radiochemical-ligand binding assay for methotrexate

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the identification of a folate compound of human serum

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of 7-hydroxymethotrexate during methotrexate anti-cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects on dihydrofolate reductase of methotrexate metabolites and intracellular folates formed following methotrexate exposure of human breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions between 7-hydroxymethotrexate and folinic acid in RAJI cells, in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid high-pressure liquid chromatographic determination of methotrexate and its metabolites 7-hydroxymethotrexate and 2,4-diamino-N(10)-methylpteroic acid in biological fluids

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intestinal conversion of folinic acid to 5-methyltetrahydrofolate in man

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Laser differential light-scattering bioassay for methotrexate (NSC-740)

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma and tumor tissue pharmacology of high-dose intravenous leucovorin calcium in combination with fluorouracil in patients with advanced colorectal carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mathematical modeling ?Guide to high-dose methotrexate infusion therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection by high-performance liquid chromatography of methotrexate and its metabolites in tumor tissue from osteosarcoma patients treated with high-dose methotrexate/leucovorin rescue

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of serum methotrexate and 7-hydroxymethotrexate concentrations. Method evaluation showing advantages of high-performance liquid chromatography

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The use of microparticulate reversed-phase packing in high-pressure liquid chromatography of compounds of biological interest

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An investigation into the source of the deglutamated metabolites of methotrexate in patients treated with high dose infusions

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microbiological analysis of 5-formyltetrahydrofolic acid and other folates using an automatic 96-well plate reader

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stereospecificity at carbon 6 of fomyltetrahydrofolate as a competitive inhibitor of transport and cytotoxicity of methotrexate in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Folates in plasma and bile of man after feeding folic acid—3H and 5-formyltetrahydrofolate (folinic acid)

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of leucovorin rescue using a new methotrexate-independent biochemical assay for leucovorin and N5-methyltetrahydrofolate

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

7-Hydroxymethotrexate cytotoxicity and selectivity in a human Burkitt's lymphoma cell line versus human granulocytic progenitor cells: rescue by folinic acid and nucleosides

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A comparative study on the pharmacokinetics of methotrexate in a dose range of 0.5 g to 33.6 g/m2 in children with acute lymphoblastic leukemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunoassay of leucovorin: Use of 125I-labeled Protein A to detect immunological binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct determination of folate monoglutamates in plasma by high-performance liquid chromatography using an automatic precolumn-switching system as sample clean-up procedure

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of methotrexate in serum by a rapid, fully mechanized enzyme immunoassay (EMIT)

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The determination of methotrexate in serum and urine

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A radiochemical assay for N5-formyltetrahydrofolic acid (citrovorum factor) in serum and urine

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The natural and unnatural diastereomers of leucovorin: aspects of their cellular pharmacology

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of methotrexate and folic acid analogs by mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Uptake and metabolism of N 5 -formyltetrahydrofolate by L1210 leukemia cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radioimmunoassays of 7-hydroxymethotrexate and methotrexate

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disposition of intermediate-dose methotrexate in children with acute lymphocytic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of 5-methyltetrahydrofolic acid in plasma and spinal fluid by high-performance liquid chromatography, using on-column concentration and electrochemical detection

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dihydrofolate reductase inhibition assay for methotrexate

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methotrexate measurements in plasma: comparison of enzyme multiplied immunoassay technique, TDx fluorescence polarization immunoassay, and high pressure liquid chromatography

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presence of 2,4-diamino-N10-methylpteroic acid after high-dose methotrexate

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The clinical pharmacology of methotrexate.new applications of an old drug

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of the diastereoisomers of leucovorin after intravenous and oral administration to normal subjects.

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methotrexate and 7-hydroxy-methotrexate pharmacokinetics following intravenous bolus administration and high-dose infusion of methotrexate

1 reference

https://pubmed.ncbi.nlm.nih.gov/2076721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/BF00315414

1 reference

Europe PubMed Central

PubMed publication ID

10 May 2018

http://europepmc.org/abstract/MED/2076721

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

10 May 2018

http://europepmc.org/abstract/MED/2076721

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