(Q53101926)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27174785%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

title

K-Ras(V14I) -induced Noonan syndrome predisposes to tumour development in mice (English)

1 reference

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4 April 2020

1 reference

Alberto J Schuhmacher

2

1 reference

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Alba De Martino Rodriguez

4 April 2020

6

1 reference

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4 April 2020

Carmen Guerra

7

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4 April 2020

author name string

Isabel Hernández-Porras

1

1 reference

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4 April 2020

Raquel Garcia-Medina

3

1 reference

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4 April 2020

Beatriz Jiménez

4

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4 April 2020

Marta Cañamero

5

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4 April 2020

publication date

26 April 2016

1 reference

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4 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27174785%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

volume

239

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4 April 2020

issue

2

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4 April 2020

page(s)

206-217

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Hyperactive Ras in developmental disorders and cancer

4 April 2020

cites work

1 reference

Ras in cancer and developmental diseases

21 January 2018

1 reference

21 January 2018

1 reference

21 January 2018

1 reference

Gain-of-function mutations in RIT1 cause Noonan syndrome, a RAS/MAPK pathway syndrome

21 January 2018

1 reference

Activating mutations in RRAS underlie a phenotype within the RASopathy spectrum and contribute to leukaemogenesis

21 January 2018

1 reference

Noonan syndrome and clinically related disorders

21 January 2018

1 reference

Mouse models for lung cancer

21 January 2018

1 reference

Tumor predisposition in Costello syndrome

21 January 2018

1 reference

21 January 2018

RAS diseases in children

1 reference

Cancer risk in patients with Noonan syndrome carrying a PTPN11 mutation.

21 January 2018

1 reference

Malignancy in Noonan syndrome and related disorders

21 January 2018

1 reference

Cancer in Noonan, Costello, cardiofaciocutaneous and LEOPARD syndromes.

21 January 2018

1 reference

Cancer spectrum and frequency among children with Noonan, Costello, and cardio-facio-cutaneous syndromes

21 January 2018

1 reference

K-RasV14I recapitulates Noonan syndrome in mice

21 January 2018

1 reference

Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context

21 January 2018

1 reference

Role of the INK4a locus in tumor suppression and cell mortality.

21 January 2018

1 reference

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

21 January 2018

1 reference

Adenoviral augmentation of elafin protects the lung against acute injury mediated by activated neutrophils and bacterial infection

21 January 2018

1 reference

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

21 January 2018

1 reference

Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.

21 January 2018

1 reference

Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras

21 January 2018

1 reference

Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

21 January 2018

1 reference

Identification of cancer initiating cells in K-Ras driven lung adenocarcinoma.

21 January 2018

1 reference

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

21 January 2018

1 reference

Genetics and biology of pancreatic ductal adenocarcinoma.

21 January 2018

1 reference

21 January 2018

Cancer statistics, 2013

1 reference

Genetically engineered mouse models of pancreatic adenocarcinoma

21 January 2018

1 reference

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

21 January 2018

1 reference

Risk of pancreatic adenocarcinoma in chronic pancreatitis

21 January 2018

1 reference

Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence

21 January 2018

1 reference

21 January 2018

1 reference

Wildtype Kras2 can inhibit lung carcinogenesis in mice

21 January 2018

1 reference

Wild-type H- and N-Ras promote mutant K-Ras-driven tumorigenesis by modulating the DNA damage response

21 January 2018

1 reference

Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders

21 January 2018

1 reference

Germline KRAS mutations cause Noonan syndrome

21 January 2018

1 reference

Biochemical and functional characterization of germ line KRAS mutations

21 January 2018

1 reference

Noonan syndrome caused by germline KRAS mutation in Taiwan: report of two patients and a review of the literature

21 January 2018

1 reference

Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus

21 January 2018

1 reference

Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma

21 January 2018

1 reference

LKB1 modulates lung cancer differentiation and metastasis

21 January 2018

1 reference

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

21 January 2018

1 reference

LOH of chromosome 12p correlates with Kras2 mutation in non-small cell lung cancer

21 January 2018

1 reference

A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma.

21 January 2018

1 reference

HRAS mutations in Costello syndrome: detection of constitutional activating mutations in codon 12 and 13 and loss of wild-type allele in malignancy.

21 January 2018

1 reference

Endogenous expression of Hras(G12V) induces developmental defects and neoplasms with copy number imbalances of the oncogene

21 January 2018

1 reference

Autoimmune disease and multiple autoantibodies in 42 patients with RASopathies

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/PATH.4719

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27174785%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

1 reference