(Q53148072)

11 May 2018

title

Druggability of the CK2 inhibitor CX-4945 as an anticancer drug and beyond. (English)

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11 May 2018

author name string

Jiyeon Kim

series ordinal

1

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11 May 2018

Seong Hwan Kim

series ordinal

2

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11 May 2018

publication date

1 August 2012

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11 May 2018

Archives of Pharmacal Research

published in

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11 May 2018

volume

35

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11 May 2018

issue

8

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11 May 2018

page(s)

1293-1296

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11 May 2018

Interleukin-6 in bone metastasis and cancer progression.

cites work

1 reference

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Unprecedented selectivity and structural determinants of a new class of protein kinase CK2 inhibitors in clinical trials for the treatment of cancer

21 January 2018

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Functional interaction of protein kinase CK2 and c-Myc in lymphomagenesis

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Protein kinase CK2 modulates IL-6 expression in inflammatory breast cancer

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-012-0800-9

Structural basis of CX-4945 binding to human protein kinase CK2

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-012-0800-9

Protein kinase CK2 and its role in cellular proliferation, development and pathology

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Protein kinase CK2 in human diseases.

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CK2 inhibition induces apoptosis via the ER stress response

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Cell cycle and activation of CK2.

21 January 2018

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Inhibition of protein kinase CK2 suppresses angiogenesis and hematopoietic stem cell recruitment to retinal neovascularization sites.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-012-0800-9

Protein kinase CK2: signaling and tumorigenesis in the mammary gland

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Protein kinase CK2: structure, regulation and role in cellular decisions of life and death

21 January 2018

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One-thousand-and-one substrates of protein kinase CK2?

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Role for casein kinase 2 in the regulation of HIF-1 activity

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Pre-clinical characterization of CX-4945, a potent and selective small molecule inhibitor of CK2 for the treatment of cancer

21 January 2018

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Discovery and SAR of 5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic acid (CX-4945), the first clinical stage inhibitor of protein kinase CK2 for the treatment of cancer

21 January 2018

1 reference

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Protein kinase CK2 is a key activator of histone deacetylase in hypoxia-associated tumors

21 January 2018

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Role of Akt signaling in vascular homeostasis and angiogenesis

21 January 2018

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CX-4945, an orally bioavailable selective inhibitor of protein kinase CK2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy

21 January 2018

1 reference

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RhoC GTPase overexpression modulates induction of angiogenic factors in breast cells

21 January 2018

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Downregulation of CK2 induces apoptosis in cancer cells--a potential approach to cancer therapy

21 January 2018

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10.1007/S12272-012-0800-9

21 January 2018

Identifiers

DOI

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11 May 2018

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11 May 2018