(Q53232489)

English

Inflammatory mechanisms in Alzheimer's disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists.

scientific article published in January 2000

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/10632585

Inflammatory mechanisms in Alzheimer's disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772401&resulttype=core&format=json

12 May 2020

0 references

Alzheimer's disease

0 references

1 reference

based on heuristic

inferred from title

toxic encephalopathy

1 reference

based on heuristic

inferred from title

author name string

C K Combs

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772401&resulttype=core&format=json

12 May 2020

D E Johnson

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772401&resulttype=core&format=json

12 May 2020

J C Karlo

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772401&resulttype=core&format=json

12 May 2020

S B Cannady

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772401&resulttype=core&format=json

12 May 2020

G E Landreth

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772401&resulttype=core&format=json

12 May 2020

language of work or name

0 references

publication date

1 January 2000

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/10632585

Journal of Neuroscience

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772401&resulttype=core&format=json

12 May 2020

20

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772401&resulttype=core&format=json

12 May 2020

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772401&resulttype=core&format=json

12 May 2020

558-567

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772401&resulttype=core&format=json

12 May 2020

Inflammation and Alzheimer's disease: mechanisms and therapeutic strategies

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Experimental models used to investigate the differential inhibition of cyclooxygenase-1 and cyclooxygenase-2 by non-steroidal anti-inflammatory drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid protein-dependent nitric oxide production from microglial cells and neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An L1-like molecule, the 8D9 antigen, is a potent substrate for neurite extension

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evolution of Alzheimer's disease related cortical lesions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptors: a nuclear receptor signaling pathway in lipid physiology

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglia in degenerative neurological disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased expression of cyclooxygenases and peroxisome proliferator-activated receptor-gamma in Alzheimer's disease brains

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglia and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of maturation in cultured human monocytic leukemia cells by a phorbol diester

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti‐inflammatory agents as a therapeutic approach to Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglial response to amyloid plaques in APPsw transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Risk of Alzheimer's disease and duration of NSAID use.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthetic Alzheimer amyloid beta/A4 peptides enhance production of complement C3 component by cultured microglial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Senile plaques stimulate microglia to release a neurotoxin found in Alzheimer brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglial release of nitric oxide by the synergistic action of beta-amyloid and IFN-gamma

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nonsteroidal anti-inflammatory drugs in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-inflammatory drugs in the fight against Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-amyloid (25-35) peptide and IFN-gamma synergistically induce the production of the chemotactic cytokine MCP-1/JE in monocytes and microglial cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclooxygenases and the central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PPARgamma in monocytes: less pain, any gain?

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nonsteroidal antiinflammatory drugs--differences and similarities

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The emerging role of thiazolidinediones in the treatment of diabetes-mellitus and related disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of microglial signal transduction pathways mediating a neurotoxic response to amyloidogenic fragments of beta-amyloid and prion proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evolution of neuronal changes in the course of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-amyloid protein enhances macrophage production of oxygen free radicals and glutamate

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of aspirin and nonsteroidal anti-inflammatory drugs on prostaglandins

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specific domains of beta-amyloid from Alzheimer plaque elicit neuron killing in human microglia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytotoxicity of microglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell death in prion disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fibrillar beta-amyloid induces microglial phagocytosis, expression of inducible nitric oxide synthase, and loss of a select population of neurons in the rat CNS in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reactive glia as rivals in regulating neuronal survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of microglial cells by beta-amyloid protein and interferon-gamma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclooxygenase in biology and disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid induces increased release of interleukin-1 beta from lipopolysaccharide-activated human monocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation of the brain in Alzheimer's disease: implications for therapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of Alzheimer beta-amyloid peptide with the human monocytic cell line THP-1 results in a protein kinase C-dependent secretion of tumor necrosis factor-alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical trial of indomethacin in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Scientific rationale for specific inhibition of COX-2

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid fibrils activate tyrosine kinase-dependent signaling and superoxide production in microglia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipopolysaccharide induction of the tumor necrosis factor-alpha promoter in human monocytic cells. Regulation by Egr-1, c-Jun, and NF-kappaB transcription factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Frequency of stages of Alzheimer-related lesions in different age categories

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid fibrils activate parallel mitogen-activated protein kinase pathways in microglia and THP1 monocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-inflammatory drugs and their mechanism of action

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of microglia and host prion protein in neurotoxicity of a prion protein fragment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thiazolidinediones--the new insulin enhancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of inhibitor time-dependency on selectivity towards cyclooxygenase isoforms

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of glutamate in cultures of human monocytic THP-1 and astrocytoma U-373 MG cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of the immune system in neurodegenerative disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Troglitazone: a review of its use in the management of type 2 diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reciprocal control of inflammatory cytokines, IL-1 and IL-6, and β-amyloid production in cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid-beta induces chemokine secretion and monocyte migration across a human blood--brain barrier model

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Roles of COX-1 and COX-2

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuropathological indexes of Alzheimer's disease in demented and nondemented persons aged 80 years and older

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Orphan nuclear receptors: shifting endocrinology into reverse

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toxicity of human THP-1 monocytic cells towards neuron-like cells is reduced by non-steroidal anti-inflammatory drugs (NSAIDs).

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The importance of inflammatory mechanisms in Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential activation of peroxisome proliferator-activated receptors by eicosanoids.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclopentenone prostaglandins suppress activation of microglia: down-regulation of inducible nitric-oxide synthase by 15-deoxy-Delta12,14-prostaglandin J2

1 reference

https://pubmed.ncbi.nlm.nih.gov/10632585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.20-02-00558.2000

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772401&resulttype=core&format=json

12 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772401&resulttype=core&format=json

12 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772401&resulttype=core&format=json

12 May 2020

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