(Q53237934)

English

Glycogen synthase kinase-3beta phosphorylates protein tau and rescues the axonopathy in the central nervous system of human four-repeat tau transgenic mice.

scientific article published in December 2000

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11007782%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

Glycogen synthase kinase-3beta phosphorylates protein tau and rescues the axonopathy in the central nervous system of human four-repeat tau transgenic mice (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11007782%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

phosphorylation

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11

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31 October 2019

14

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11007782%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

author name string

Spittaels K

1

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31 October 2019

Van den Haute C

2

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31 October 2019

Van Dorpe J

3

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31 October 2019

Geerts H

4

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31 October 2019

Mercken M

5

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31 October 2019

Bruynseels K

6

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31 October 2019

Lasrado R

7

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31 October 2019

Vandezande K

8

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31 October 2019

Laenen I

9

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31 October 2019

Boon T

10

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31 October 2019

Vandenheede J

12

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31 October 2019

Moechars D

13

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31 October 2019

Van Leuven F

15

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31 October 2019

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publication date

1 December 2000

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31 October 2019

Journal of Biological Chemistry

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31 October 2019

275

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31 October 2019

52

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31 October 2019

41340-41349

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31 October 2019

A protein factor essential for microtubule assembly

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Expression of multiple tau isoforms and microtubule bundle formation in fibroblasts transfected with a single tau cDNA.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Tau domains, phosphorylation, and interactions with microtubules.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegeneration

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Phosphorylation sites on tau by tau protein kinase I, a bovine derived kinase generating an epitope of paired helical filaments

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Phosphorylation of tau by glycogen synthase kinase 3beta affects the ability of tau to promote microtubule self-assembly

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

The phosphorylation of tau: a critical stage in neurodevelopment and neurodegenerative processes.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Characterization of tau phosphorylation in glycogen synthase kinase-3beta and cyclin dependent kinase-5 activator (p23) transfected cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Proline-directed and non-proline-directed phosphorylation of PHF-tau.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Preferential labeling of Alzheimer neurofibrillary tangles with antisera for tau protein kinase (TPK) I/glycogen synthase kinase-3 beta and cyclin-dependent kinase 5, a component of TPK II.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Immunocytochemistry of tau phosphoserine 413 and tau protein kinase I in Alzheimer pathology

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

The tau mutation (val337met) disrupts cytoskeletal networks of microtubules

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Age-related changes in spontaneous behavior and learning in NMRI mice from middle to old age.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Postmortem changes in the phosphorylation state of tau-protein in the rat brain.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Monoclonal antibodies with selective specificity for Alzheimer Tau are directed against phosphatase-sensitive epitopes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Detection of phosphorylated Ser262 in fetal tau, adult tau, and paired helical filament tau.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Age-Dependent Emergence and Progression of a Tauopathy in Transgenic Mice Overexpressing the Shortest Human Tau Isoform

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

A taxol-dependent procedure for the isolation of microtubules and microtubule-associated proteins (MAPs).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the london mutant of human APP in neurons.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Transgenic expression of the shortest human tau affects its compartmentalization and its phosphorylation as in the pretangle stage of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Tau phosphorylation in transgenic mice expressing glycogen synthase kinase-3beta transgenes.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Human tau becomes phosphorylated and forms filamentous deposits when overexpressed in lamprey central neurons in situ.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Morphological alterations in dorsal root ganglion neurons and supporting cells of organotypic mouse spinal cord-ganglion cultures exposed to taxol

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Neuronal overexpression of APPL, the Drosophila homologue of the amyloid precursor protein (APP), disrupts axonal transport.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Kinesin-mediated organelle translocation revealed by specific cellular manipulations

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Lithium inhibits Alzheimer's disease-like tau protein phosphorylation in neurons.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Chronic lithium treatment robustly protects neurons in the central nervous system against excitotoxicity by inhibiting N-methyl-D-aspartate receptor-mediated calcium influx

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Modulation of PHF-like tau phosphorylation in cultured neurones and transfected cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Phosphorylation of tau by glycogen synthase kinase-3β in intact mammalian cells: The effects on the organization and stability of microtubules

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

Mutations in tau reduce its microtubule binding properties in intact cells and affect its phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006219200

21 January 2018

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